Results 1 to 10 of about 57,439 (194)

Transcriptomic and Epitranscriptomic Landscape of Integrated HTLV-1 in MT2 Cells [PDF]

Viruses
Human T-lymphotropic virus type 1 (HTLV-1), the first human retrovirus identified, is linked to adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis.
Shuanglong Wei, Bohan Zhang, Jingwan Han, Hanping Li, Yongjian Liu, Lei Jia, Jingyun Li, Xiaotian Huang, Lin Li   +8 more
doaj   +2 more sources

Analysis of RNA Transcribed by RNA Polymerase III from B2 SINEs in Mouse Cells [PDF]

Non-Coding RNA
Background/Objectives: SINEs (short interspersed elements) are eukaryotic non-autonomous retrotransposons. They are transcribed by RNA polymerase III (pol III) and generate non-coding RNAs.
Olga R. Borodulina, Sergey A. Kosushkin, Ilia G. Ustyantsev, Nikita S. Vassetzky, Dmitri A. Kramerov   +4 more
doaj   +2 more sources

Long-Read RNA Sequencing Identifies Polyadenylation Elongation and Differential Transcript Usage of Host Transcripts During SARS-CoV-2 In Vitro Infection

Frontiers in Immunology, 2022
Better methods to interrogate host-pathogen interactions during Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections are imperative to help understand and prevent this disease.
Jessie J.-Y. Chang, Josie Gleeson, Daniel Rawlinson, Ricardo De Paoli-Iseppi, Chenxi Zhou, Francesca L. Mordant, Sarah L. Londrigan, Michael B. Clark, Kanta Subbarao, Kanta Subbarao, Timothy P. Stinear, Lachlan J. M. Coin, Lachlan J. M. Coin, Lachlan J. M. Coin, Lachlan J. M. Coin, Miranda E. Pitt   +15 more
doaj   +1 more source

Stage-Specific Alternative Polyadenylation During Human Neural Differentiation Revealed by Integrated Long- and Short-Read Sequencing. [PDF]

Biology (Basel)
Lou Z, Zeng X, Jiang T, Du P, Rao J, Dai X, Lin H, Zhu Y.   +7 more
europepmc   +3 more sources

Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3′ end biogenesis

eLife, 2022
3′ end formation of most eukaryotic mRNAs is dependent on the assembly of a ~1.5 MDa multiprotein complex, that catalyzes the coupled reaction of pre-mRNA cleavage and polyadenylation. In mammals, the cleavage and polyadenylation specificity factor (CPSF)
Lena Maria Muckenfuss, Anabel Carmen Migenda Herranz, Franziska Maria Boneberg, Marcello Clerici, Martin Jinek   +4 more
doaj   +1 more source

The transcriptional elongation rate regulates alternative polyadenylation in yeast

eLife, 2020
Yeast cells undergoing the diauxic response show a striking upstream shift in poly(A) site utilization, with increased use of ORF-proximal poly(A) sites resulting in shorter 3’ mRNA isoforms for most genes.
Joseph V Geisberg, Zarmik Moqtaderi, Kevin Struhl   +2 more
doaj   +1 more source

Alternative Polyadenylation Blooms [PDF]

Developmental Cell, 2010
Alternative polyadenylation generates mRNAs with 3' untranscribed regions of different lengths, often affecting transcript stability. Hornyik et al., in this issue of Developmental Cell, and Liu et al. now demonstrate a role for alternative polyadenylation in gene silencing and the regulation of flowering time in Arabidopsis thaliana.
Rosonina, Emanuel, Manley, James L.
openaire   +2 more sources

Nuclear polyadenylation factors recognize cytoplasmic polyadenylation elements. [PDF]

Genes & Development, 1994
In the cytoplasm of oocytes and early embryos, addition of poly(A) to mRNAs can activate their translation. We demonstrate that despite many differences between poly(A) addition in the cytoplasm and nucleus, these two forms of polyadenylation may involve identical trans-acting factors.
A, Bilger, C A, Fox, E, Wahle, M, Wickens   +3 more
openaire   +2 more sources

Template-switching artifacts resemble alternative polyadenylation

BMC Genomics, 2019
Background Alternative polyadenylation is commonly examined using cDNA sequencing, which is known to be affected by template-switching artifacts. However, the effects of such template-switching artifacts on alternative polyadenylation are generally ...
Zsolt Balázs, Dóra Tombácz, Zsolt Csabai, Norbert Moldován, Michael Snyder, Zsolt Boldogkői   +5 more
doaj   +1 more source

Variable 3’polyadenylation of Wheat yellow mosaic virus and its novel effects on translation and replication

Virology Journal, 2019
Background Polyadenylation influences many aspects of mRNA as well as viral RNA. variable polyadenylation at the 3' end have been reported in RNA viruses.
Guowei Geng, Chengming Yu, Xiangdong Li, Xuefeng Yuan   +3 more
doaj   +1 more source