Results 11 to 20 of about 57,483 (236)

The CNOT4 Subunit of the CCR4‐NOT Complex is Involved in mRNA Degradation, Efficient DNA Damage Repair, and XY Chromosome Crossover during Male Germ Cell Meiosis

Advanced Science, 2021
The CCR4‐NOT complex is a major mRNA deadenylase in eukaryotes, comprising the catalytic subunits CNOT6/6L and CNOT7/8, as well as CNOT4, a regulatory subunit with previously undetermined functions.
Xing‐Xing Dai, Yu Jiang, Jia‐Hui Gu, Zhi‐Yan Jiang, Yun‐Wen Wu, Chao Yu, Hao Yin, Jue Zhang, Qing‐Hua Shi, Li Shen, Qian‐Qian Sha, Heng‐Yu Fan   +11 more
doaj   +1 more source

Alterations in polyadenylation and its implications for endocrine disease

Frontiers in Endocrinology, 2013
IntroductionPolyadenylation is the process in which the pre-mRNA is cleaved at the poly(A) site and a poly(A) tail is added - a process necessary for normal mRNA formation.
Anders eRehfeld, Mireya ePlass, Anders eKrogh, Lennart eFriis-Hansen   +3 more
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RETRACTION: MicroRNA-320a Inhibits Invasion and Metastasis in Osteosarcoma by Targeting Cytoplasmic Polyadenylation Element-Binding Protein 1. [PDF]

Cancer Med
europepmc   +3 more sources

Overexpression of CPEB4 in glioma indicates a poor prognosis by promoting cell migration and invasion

Tumor Biology, 2017
Glioma is an aggressive malignancy with limited effective treatment and poor prognosis. Cytoplasmic polyadenylation element binding protein 4 is a regulator of gene transcription and has been reported to be associated with biological malignancy in ...
Liu Zhijun, Wu Dapeng, Jing Hong, Wang Guicong, Yuan Bingjian, Liu Honglin   +5 more
doaj   +1 more source

Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification

eLife, 2020
Understanding genome organization and gene regulation requires insight into RNA transcription, processing and modification. We adapted nanopore direct RNA sequencing to examine RNA from a wild-type accession of the model plant Arabidopsis thaliana and a ...
Matthew T Parker, Katarzyna Knop, Anna V Sherwood, Nicholas J Schurch, Katarzyna Mackinnon, Peter D Gould, Anthony JW Hall, Geoffrey J Barton, Gordon G Simpson   +8 more
doaj   +1 more source

Analysis of Polyadenylation Signal Usage with Full-Length Transcriptome in Spodoptera frugiperda (Lepidoptera: Noctuidae)

Insects, 2022
During the messenger RNA (mRNA) maturation process, RNA polyadenylation is a key step, and is coupled to the termination of transcription. Various cis-acting elements near the cleavage site and their binding factors would affect the process of ...
Liying Fang, Lina Guo, Min Zhang, Xianchun Li, Zhongyuan Deng   +4 more
doaj   +1 more source

Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex

eLife, 2017
3’ polyadenylation is a key step in eukaryotic mRNA biogenesis. In mammalian cells, this process is dependent on the recognition of the hexanucleotide AAUAAA motif in the pre-mRNA polyadenylation signal by the cleavage and polyadenylation specificity ...
Marcello Clerici, Marco Faini, Ruedi Aebersold, Martin Jinek   +3 more
doaj   +1 more source

Maturation of selected human mitochondrial tRNAs requires deadenylation

eLife, 2017
Human mitochondria contain a genome (mtDNA) that encodes essential subunits of the oxidative phosphorylation system. Expression of mtDNA entails multi-step maturation of precursor RNA. In other systems, the RNA life cycle involves surveillance mechanisms,
Sarah F Pearce, Joanna Rorbach, Lindsey Van Haute, Aaron R D’Souza, Pedro Rebelo-Guiomar, Christopher A Powell, Ian Brierley, Andrew E Firth, Michal Minczuk   +8 more
doaj   +1 more source

A tail of translational regulation

eLife, 2017
An RNA-binding protein called PABPC1 has an important role in determining protein synthesis rates and hypertrophy in the heart.
Gillian A Gray, Nicola K Gray
doaj   +1 more source

Cytoplasmic polyadenylation by TENT5A is required for proper bone formation

Cell Reports, 2021
Summary: Osteoblasts orchestrate bone formation through the secretion of type I collagen and other constituents of the matrix on which hydroxyapatite crystals mineralize.
Olga Gewartowska, Goretti Aranaz-Novaliches, Paweł S. Krawczyk, Seweryn Mroczek, Monika Kusio-Kobiałka, Bartosz Tarkowski, Frantisek Spoutil, Oldrich Benada, Olga Kofroňová, Piotr Szwedziak, Dominik Cysewski, Jakub Gruchota, Marcin Szpila, Aleksander Chlebowski, Radislav Sedlacek, Jan Prochazka, Andrzej Dziembowski   +16 more
doaj   +1 more source