Results 11 to 20 of about 104,090 (284)

Comprehensive profiling of rhizome-associated alternative splicing and alternative polyadenylation in moso bamboo (Phyllostachys edulis). [PDF]

The Plant Journal, 2017
Moso bamboo (Phyllostachys edulis) represents one of the fastest-spreading plants in the world, due in part to its well-developed rhizome system. However, the post-transcriptional mechanism for the development of the rhizome system in bamboo has not been
Cai, Dawei, Gao, Yubang, Gu, Lianfeng, Lin, Chentao, Ma, Liuyin, Wang, Huiyuan, Wang, Taotao, Wang, Yongsheng, Zhang, Hangxiao   +8 more
core   +2 more sources

Benchmarking sequencing methods and tools that facilitate the study of alternative polyadenylation

Genome Biology, 2021
Background Alternative cleavage and polyadenylation (APA), an RNA processing event, occurs in over 70% of human protein-coding genes. APA results in mRNA transcripts with distinct 3′ ends.
Ankeeta Shah, Briana E. Mittleman, Yoav Gilad, Yang I. Li   +3 more
doaj   +2 more sources

Mechanism of STMN2 cryptic splice-polyadenylation and its correction for TDP-43 proteinopathies

Science, 2023
Loss of nuclear TDP-43 is a hallmark of neurodegeneration in TDP-43 proteinopathies, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Michael W. Baughn, Ze’ev Melamed, Jone López-Erauskin, Melinda S. Beccari, K. Ling, A. Zuberi, Maximilliano Presa, E. Gonzalo-Gil, R. Maimon, Sonia Vazquez-Sanchez, Som Chaturvedi, Mariana Bravo-Hernández, V. Taupin, Stephen Moore, Jonathan W. Artates, Eitan S. Acks, I. S. Ndayambaje, A. R. Agra de Almeida Quadros, Paayman Jafar-nejad, F. Rigo, C. Bennett, C. Lutz, C. Lagier-Tourenne, D. Cleveland   +23 more
semanticscholar   +1 more source

Context-specific regulation and function of mRNA alternative polyadenylation

Nature reviews. Molecular cell biology, 2022
Alternative cleavage and polyadenylation (APA) is a widespread mechanism to generate mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of alternative 3′ UTR isoforms is highly cell type specific and is further controlled in a ...
Sibylle Mitschka, C. Mayr
semanticscholar   +1 more source

An atlas of alternative polyadenylation quantitative trait loci contributing to complex trait and disease heritability

Nature Genetics, 2021
Genome-wide association studies have identified thousands of noncoding variants associated with human traits and diseases. However, the functional interpretation of these variants is a major challenge. Here, we constructed a multi-tissue atlas of human 3′
Lei Li, Kai-Lieh Huang, Yipeng Gao, Ya Cui, Gao Wang, Nathan D. Elrod, Yumei Li, Y. Chen, Ping Ji, Fanglue Peng, W. Russell, Eric J. Wagner, Wei Li   +12 more
semanticscholar   +1 more source

Integrative analysis of quantitative trait loci of alternative polyadenylation and GWAS highlights key regulators of milk production and immune traits in Holstein. [PDF]

Anim Genet
Abstract Understanding the genetic regulation of complex traits like mastitis in Holstein dairy cows remains a challenge, despite significant advancements in breeding techniques. This study integrates 3′‐untranslated region alternative polyadenylation (APA) quantitative trait loci (3′aQTL) mapping with genome‐wide association studies (GWASs) to ...
Tao X, Tang Y, Liu X, Ni M, Lai W, Chen S, Yu Y.   +6 more
europepmc   +2 more sources

Arabidopsis N6-methyladenosine reader CPSF30-L recognizes FUE signal to control polyadenylation site choice in liquid-like nuclear body.

Molecular Plant, 2021
The biological functions of epitranscriptomic modification N6-methyladenosine (m6A) in plants have not been fully understood. CPSF30-L is a predominant isoform of polyadenylation factor CPSF30 and consists of CPSF30-S and m6A-binding YTH domain.
Peizhe Song, Junbo Yang, Chunling Wang, Q. Lu, Linqing Shi, Subiding Tayier, G. Jia   +6 more
semanticscholar   +1 more source

CPSF30-L-mediated recognition of mRNA m6A modification controls alternative polyadenylation of nitrate signaling-related gene transcripts in Arabidopsis.

Molecular Plant, 2021
N6-methyladenosine (m6A), a ubiquitous internal modification of eukaryotic mRNAs, plays a vital role in almost every aspect of mRNA metabolism. However, evidence regarding the role of m6A in regulating alternative polyadenylation (APA) is limited. APA is
Yifeng Hou, Jing Sun, Baixing Wu, Yangyang Gao, H. Nie, Zhentian Nie, Shuxuan Quan, Yong Wang, Xiaofeng Cao, Sisi Li   +9 more
semanticscholar   +1 more source

Alternative polyadenylation: methods, mechanism, function, and role in cancer

Journal of experimental & clinical cancer research : CR, 2021
Occurring in over 60% of human genes, alternative polyadenylation (APA) results in numerous transcripts with differing 3’ends, thus greatly expanding the diversity of mRNAs and of proteins derived from a single gene.
Yi Zhang, Lian Liu, Qiongzi Qiu, Qing Zhou, Jinwang Ding, Yan Lu, Pengyuan Liu   +6 more
semanticscholar   +1 more source

Deciphering the impact of genetic variation on human polyadenylation using APARENT2

Genome Biology, 2022
Background 3′-end processing by cleavage and polyadenylation is an important and finely tuned regulatory process during mRNA maturation. Numerous genetic variants are known to cause or contribute to human disorders by disrupting the cis-regulatory code ...
Johannes Linder, Samantha E. Koplik, Anshul B Kundaje, Georg Seelig   +3 more
semanticscholar   +1 more source