Results 21 to 30 of about 65,820 (278)
Nature Communications, 2021 Annotation of polyadenylation sites from short-read RNA sequencing alone is a challenging computational task. Other algorithms rooted in DNA sequence predict potential polyadenylation sites; however, in vivo expression of a particular site varies based ...
Ryan Lusk +5 more
semanticscholar +1 more source
Cell Discovery, 2018 N6-methyladenosine (m6A) is enriched in 3′untranslated region (3′UTR) and near stop codon of mature polyadenylated mRNAs in mammalian systems and has regulatory roles in eukaryotic mRNA transcriptome switch.
Y. Yue +16 more
semanticscholar +1 more source
Nuclear polyadenylation factors recognize cytoplasmic polyadenylation elements. [PDF]
Genes & Development, 1994 In the cytoplasm of oocytes and early embryos, addition of poly(A) to mRNAs can activate their translation. We demonstrate that despite many differences between poly(A) addition in the cytoplasm and nucleus, these two forms of polyadenylation may involve identical trans-acting factors.
Andrea Bilger +3 more
openaire +2 more sources
Nature Neuroscience, 2018 Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are associated with loss of nuclear transactive response DNA-binding protein 43 (TDP-43).
Ze’ev Melamed +19 more
semanticscholar +1 more source
Tumor Biology, 2017 Glioma is an aggressive malignancy with limited effective treatment and poor prognosis. Cytoplasmic polyadenylation element binding protein 4 is a regulator of gene transcription and has been reported to be associated with biological malignancy in ...
Liu Zhijun +5 more
doaj +1 more source
Mechanisms of mRNA polyadenylation
TURKISH JOURNAL OF BIOLOGY, 2016 mRNA 3'-end processing involves the addition of a poly(A) tail based on the recognition of the poly(A) signal and subsequent cleavage of the mRNA at the poly(A) site. Alternative polyadenylation (APA) is emerging as a novel mechanism of gene expression regulation in normal and in disease states.
Agus, Hizlan Hincal +1 more
openaire +4 more sources
Maturation of selected human mitochondrial tRNAs requires deadenylation
eLife, 2017 Human mitochondria contain a genome (mtDNA) that encodes essential subunits of the oxidative phosphorylation system. Expression of mtDNA entails multi-step maturation of precursor RNA. In other systems, the RNA life cycle involves surveillance mechanisms,
Sarah F Pearce +8 more
doaj +1 more source
PLoS Genetics, 2018 The N6-methyladenosine (m6A) modification is the most prevalent internal RNA modification in eukaryotes. The majority of m6A sites are found in the last exon and 3’ UTRs.
Seth D. Kasowitz +8 more
semanticscholar +1 more source
A tail of translational regulation
eLife, 2017 An RNA-binding protein called PABPC1 has an important role in determining protein synthesis rates and hypertrophy in the heart.
Gillian A Gray, Nicola K Gray
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 In mammalian species, both the maturation promoting factor (MPF) and the mitogen-activated protein kinase (MAPK) cascade play critical roles in modulating oocyte meiotic cell-cycle progression. MPF is a critical heterodimer composed of CDK1 and cyclin B1.
Lan-Rui Cao, Jun-Chao Jiang, Heng-Yu Fan
doaj +1 more source