Results 21 to 30 of about 57,483 (236)
Frontiers in Cellular Neuroscience, 2019 Alternative polyadenylation (APA) is a widespread mechanism involving about half of the expressed genes, resulting in varying lengths of the 3′ untranslated region (3′UTR).
Elena Grassi +13 more
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Frontiers in Cell and Developmental Biology, 2020 In mammalian species, both the maturation promoting factor (MPF) and the mitogen-activated protein kinase (MAPK) cascade play critical roles in modulating oocyte meiotic cell-cycle progression. MPF is a critical heterodimer composed of CDK1 and cyclin B1.
Lan-Rui Cao, Jun-Chao Jiang, Heng-Yu Fan
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Mitochondrial Polyadenylation Is a One-Step Process Required for mRNA Integrity and tRNA Maturation. [PDF]
PLoS Genetics, 2016 Polyadenylation has well characterised roles in RNA turnover and translation in a variety of biological systems. While polyadenylation on mitochondrial transcripts has been suggested to be a two-step process required to complete translational stop codons,
Ana Bratic +8 more
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Bacterial/archaeal/organellar polyadenylation [PDF]
WIREs RNA, 2010 AbstractAlthough the first poly(A) polymerase (PAP) was discovered in Escherichia coli in 1962, the study of polyadenylation in bacteria was largely ignored for the next 30 years. However, with the identification of the structural gene for E. coli PAP I in 1992, it became possible to analyze polyadenylation using both biochemical and genetic approaches.
Bijoy K, Mohanty, Sidney R, Kushner
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A novel cause of DKC1‐related bone marrow failure: Partial deletion of the 3′ untranslated region
eJHaem, 2021 Telomere biology disorders (TBDs), including dyskeratosis congenita (DC), are a group of rare inherited diseases characterized by very short telomeres. Mutations in the components of the enzyme telomerase can lead to insufficient telomere maintenance in ...
Jonathan W. Arthur +14 more
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Nuclear Polyadenylate-Binding Protein [PDF]
Molecular and Cellular Biology, 1985 Polyadenylate-binding activity can be detected in eluates from sodium dodecyl sulfate gels by a nitrocellulose filter-binding assay. Nuclear extracts from rat liver show a single peak of binding activity at 50 to 55 kilodaltons; cytoplasmic extracts show a single peak at 70 to 80 kilodaltons, corresponding to a 75-kilodalton protein previously ...
A B, Sachs, R D, Kornberg
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Non‐polyadenylated mRNAs from eukaryotes [PDF]
FEBS Letters, 1980 The investigation of eukaryotic mRNA has focussed on molecules that possess a 3’-terminal poly(A) seg ment [l-3] since they can be isolated easily by virtue of their high affinity for oligo(dT)-cellulose [4,5], poly(U)-Sepharose [6,7] or Millipore filters [8].
Katinakis, P.K. +2 more
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Frontiers in Genetics, 2019 The length of untranslated regions at the 3′ end of transcripts (3′UTRs) is regulated by alternate polyadenylation (APA). 3′UTRs contain regions that harbor binding motifs for regulatory molecules. However, the mechanisms that coordinate the 3′UTR length
Benjamin J. Harrison +14 more
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Intragenic CpG Islands and Their Impact on Gene Regulation
Frontiers in Cell and Developmental Biology, 2022 The mammalian genome is depleted in CG dinucleotides, except at protected regions where they cluster as CpG islands (CGIs). CGIs are gene regulatory hubs and serve as transcription initiation sites and are as expected, associated with gene promoters ...
James A. Cain +2 more
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RNA binding protein Caprin-2 is a pivotal regulator of the central osmotic defense response
eLife, 2015 In response to an osmotic challenge, the synthesis of the antidiuretic hormone arginine vasopressin (AVP) increases in the hypothalamus, and this is accompanied by extension of the 3′ poly(A) tail of the AVP mRNA, and the up-regulation of the expression ...
Agnieszka Konopacka +4 more
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