Results 21 to 30 of about 104,144 (317)
Alternative polyadenylation: methods, mechanism, function, and role in cancer
Journal of experimental & clinical cancer research : CR, 2021 Occurring in over 60% of human genes, alternative polyadenylation (APA) results in numerous transcripts with differing 3’ends, thus greatly expanding the diversity of mRNAs and of proteins derived from a single gene.
Yi Zhang +6 more
semanticscholar +1 more source
To polyadenylate or to deadenylate [PDF]
Cell Cycle, 2010 mRNA polyadenylation and deadenylation are important processes that allow rapid regulation of gene expression in response to different cellular conditions. Almost all eukaryotic mRNA precursors undergo a co-transcriptional cleavage followed by polyadenylation at the 3' end.
Anders Virtanen +2 more
openaire +3 more sources
The landscape of alternative polyadenylation in single cells of the developing mouse embryo
Nature Communications, 2021 3′ untranslated regions (3′ UTRs) post-transcriptionally regulate mRNA stability, localization, and translation rate. While 3′-UTR isoforms have been globally quantified in limited cell types using bulk measurements, their differential usage among cell ...
Vikram Agarwal +3 more
semanticscholar +1 more source
Nature Communications, 2021 Annotation of polyadenylation sites from short-read RNA sequencing alone is a challenging computational task. Other algorithms rooted in DNA sequence predict potential polyadenylation sites; however, in vivo expression of a particular site varies based ...
Ryan Lusk +5 more
semanticscholar +1 more source
Cell Discovery, 2018 N6-methyladenosine (m6A) is enriched in 3′untranslated region (3′UTR) and near stop codon of mature polyadenylated mRNAs in mammalian systems and has regulatory roles in eukaryotic mRNA transcriptome switch.
Y. Yue +16 more
semanticscholar +1 more source
Components required for in vitro cleavage and polyadenylation of eukaryotic mRNA [PDF]
, 1988 We have studied in vitro cleavage/polyadenylation of precursor RNA containing herpes simplex virus type 2 poly A site sequences and have analysed four RNA/protein complexes which form during in vitro reactions.
Clements, J.B. +3 more
core +1 more source
Nuclear polyadenylation factors recognize cytoplasmic polyadenylation elements. [PDF]
Genes & Development, 1994 In the cytoplasm of oocytes and early embryos, addition of poly(A) to mRNAs can activate their translation. We demonstrate that despite many differences between poly(A) addition in the cytoplasm and nucleus, these two forms of polyadenylation may involve identical trans-acting factors.
Andrea Bilger +3 more
openaire +2 more sources
eLife, 2017 3’ polyadenylation is a key step in eukaryotic mRNA biogenesis. In mammalian cells, this process is dependent on the recognition of the hexanucleotide AAUAAA motif in the pre-mRNA polyadenylation signal by the cleavage and polyadenylation specificity ...
Marcello Clerici +3 more
doaj +1 more source
Dual Requirement for Yeast hnRNP Nab2p in mRNA poly(A) Tail Length Control and Nuclear Export [PDF]
, 2002 Recent studies of mRNA export factors have provided additional evidence for a mechanistic link between mRNA 3′‐end formation and nuclear export. Here, we identify Nab2p as a nuclear poly(A)‐binding protein required for both poly(A) tail length control ...
Anderson, James T. +8 more
core +3 more sources
Nature Neuroscience, 2018 Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are associated with loss of nuclear transactive response DNA-binding protein 43 (TDP-43).
Ze’ev Melamed +19 more
semanticscholar +1 more source