Results 211 to 220 of about 58,232 (298)

Increased expression of aromatase after focal cerebral ischemia: Relevance to neuroprotection and functional recovery

Neuroprotection, Volume 4, Issue 2, Page 143-156, June 2026.
Abstract Aim Aromatase is the key enzyme in the biosynthesis of 17β‐estradiol, the most potent estrogen, which has pleiotropic neuroprotective properties. Aromatase levels increase in the brain after stroke, and its gene variants increase susceptibility to stroke. This study aims to determine whether aromatase overexpression improves stroke outcome and
Lindsay Gallagher, Anna F. Dominiczak, Luis M. Garcia‐Segura, Nobuhiro Harada, J. B. Hutchison, James M. Mullin, Delyth Graham, Peter O'Shaughnessy, Hilary Victoria O. Carswell   +8 more
wiley   +1 more source

Polyamine Metabolism and the DHPS/eIF5A Hypusination Axis: From Metabolic Reprogramming to a Therapeutic Achilles' Heel in Melanoma. [PDF]

Biomolecules
Liu KL, Zhang S, Li FS, Chen MJ, Chen YY, Zhang N, Wang K.   +6 more
europepmc   +1 more source

Uric Acid in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Portal Hypertension &Cirrhosis, Volume 5, Issue 2, Page 189-206, June 2026.
MASLD is the most prevalent chronic liver disease worldwide, yet effective pharmacological treatments remain limited. Hyperuricemia is now recognized as a key driver of hepatic steatosis, inflammation, and fibrosis, with elevated serum uric acid levels independently predicting hepatocellular carcinoma and liver‐related mortality.
Rong Wang, Zhenyu Liu, Jun Lin, Weijing Zhang, Xianzhi Liu, Tong Zhang   +5 more
wiley   +1 more source

A direct fluorescence assay for quantitative analysis of ornithine decarboxylase activity and inhibitor screening. [PDF]

J Biol Chem
Choi JY, Bereta G, Furry M, Vanderwal CD, Grudnik P, Ben Mamoun C.   +5 more
europepmc   +1 more source

From Plasma Chemistry to Adhesion Strength: Mechanical Characterization of Pure Versus Mixed Aminosilane Films for Bonding Polyurea to Aluminum

Plasma Processes and Polymers, Volume 23, Issue 6, June 2026.
Plasma‐polymerized aminosilane films act as effective primers for bonding polyurea adhesives to aluminum. While pure APTES quadruples joint strength, co‐polymerization with silazanes or other monomers surprisingly degrades adhesion. This reveals a shift in the governing mechanism for adhesion: once a threshold of reactive surface amines is available ...
Thomas D. Michl, Alain Schwegler, Katerina Zvolska, Michael Grob, Philippe Keller, Raphael Schaller, Heiko Jung, Marcel Fischer, Philipp Frei, Erik Roos, Klaus Kresser, Yaser Hamedi, Dhia Ben Salem, Sonja Neuhaus   +13 more
wiley   +1 more source

Probiotic and microbial modulation of polyamine production: an emerging avenue for neuroprotection in neurodegenerative disorders. [PDF]

Amino Acids
Adhikari T, Saha P.
europepmc   +1 more source

Biophysical assessment of the molecular mechanisms of Tau aggregation and its role in Alzheimer's disease

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Alzheimer's disease (AD) is characterized by the intracellular aggregation of the microtubule‐associated protein Tau. While the presence of large, insoluble neurofibrillary tangles has long been the primary focus of this research, a paradigm shift in the field now highlights smaller, soluble oligomers as the more neurotoxic Tau species leading
Joshua T. Skrehot, Dmitry Kurouski
wiley   +1 more source

Spermidine biosynthesis by hypervirulent <i>Francisella tularensis</i> promotes fitness and salvages adenine. [PDF]

J Bacteriol
Yue Y, Shinde D, Moore R, Yu Y, Thomas VC, Helikar T, Larson MA.   +6 more
europepmc   +1 more source

Boron‐10 carriers and their applications in boron neutron capture therapy

Precision Radiation Oncology, Volume 10, Issue 2, Page 205-241, June 2026.
Summary of different types of boron drugs. Abstract Boron neutron capture therapy (BNCT) has emerged as a promising therapeutic modality in cancer treatment, demonstrating the ability to selectively eliminate cancer cells through the 10B(n,α)7Li nuclear reaction with minimal side effects on normal tissues.
Dachao Tang, Mengqi Shi, Zhichen Mao, Weiya Chen, Xiaoling Li, Xiao Yan Zhao, Zhigang Liu, Xiao Xu   +7 more
wiley   +1 more source

Polyamine metabolism as a regulator of cellular and organismal aging. [PDF]

Amino Acids
Uemura T, Takayama J, Oguro A, Terui Y.
europepmc   +1 more source