Results 261 to 270 of about 106,104 (288)

Biochemical and Comparative Proteomic Analyses Delineate the Anti‐Ovarian Carcinogenic Roles of Modified Calycosin

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
The modified calycosin derivative H10 was more effective in inhibiting cell proliferation through G0/G1 cell cycle arrest, together with inhibiting the migration and colony formation abilities of ovarian cancer cell lines SKOV3 and A2780. Comparative proteomic analysis coupled with Ingenuity Pathway Analysis further delineated calycosin derivative H10 ...
Fuhong Yang, Xin Li, Hanchi Gao, Pei Yao, Xian Qin, Xiao Lin, Keng Po Lai, Jing Tian, Jian Chen   +8 more
wiley   +1 more source

Involvement of Surface Receptors in the Uptake and Cellular Responses Induced by Cationic Polyamine-Based Carbon Dots in Macrophages. [PDF]

Toxics
Cerland A, Harmouch E, Rapp M, Lebeau L, Pons F, Ronzani C.   +5 more
europepmc   +1 more source

A Nonketotic Hyperglycinemia Mouse Shows Wide‐Ranging Biochemical Consequences of Elevated Glycine, Reduced Folate One‐Carbon Charging, and Serine Deficiency

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT Nonketotic hyperglycinemia is a severe neonatal epileptic encephalopathy caused by deficient glycine cleavage enzyme activity, for which currently no effective treatment exists. Incomplete understanding of brain biochemistry represents a major knowledge gap to develop new treatments.
Michael A. Swanson, Hua Jiang, Lakshmi Divya Kolora, Rachel Molino, Richard Reisdorph, Cole R. Michel, Katrina A. Doenges, Kit‐Yi Leung, Xiangping Lin, Frank Wong, Samual Lancaster, Basil Michael, Michael Snyder, Daniella H. Hock, David A. Stroud, Tim Wood, Robert Binard, Laura Anderson‐Lehman, Uwe Christians, Erland Arning, Marisa W. Friederich, Roxanne A. Van Hove, Kenneth N. MacLean, Nicholas D. E. Greene, Johan L. K. Van Hove   +24 more
wiley   +1 more source

Dysbiosis modulates CD8⁺ tissue-resident memory cells through a mechanism requiring polyamine metabolism during HIV infection. [PDF]

iScience
Jayaraman S, Mahalingam S, Lederman MM, Faddoul F, Paes da Silva A, Asaad R, Shriver LP, Bhaskaran N, Schneider E, Heine G, Taylor T, Horne S, Yoon A, Zhu Z, Zhang L, Burgener A, Lewin G, Pandiyan P.   +17 more
europepmc   +1 more source

PEG‐Dialdehydes/Hyperbranched Amines Based Hydrogels and their Potential as Futures Bone Adhesives

Macromolecular Materials and Engineering, Volume 311, Issue 1, January 2026.
Different length crosslinkers are blended and used to synthesize hydrogels with the potential use as bone adhesives. With decreasing average crosslinker length, gelation time drops, while the gel strength increases. The hydrogel properties do not affect the bond strength, neither on bone nor on synthetic substrates.
Kyriakos Karakyriazis, Sebastian Stößlein, Andreas Hartwig   +2 more
wiley   +1 more source

ATP13A2-Mediated Spermine Export Modulates Lipid Catabolism in the Endolysosomal System of SH-SY5Y Cells. [PDF]

Int J Mol Sci
Marcos AL, Gironacci MM, de Tezanos Pinto F.   +2 more
europepmc   +1 more source

The Role of Macrophages in Cancer: From Basic Research to Clinical Applications

MedComm, Volume 7, Issue 1, January 2026.
Monocytes infiltrate the tumor microenvironment (TME) and differentiate into macrophages, which polarize into proinflammatory, antitumor M1 cells or immunosuppressive, protumor M2 cells. Within the TME, M2‐type tumor‐associated macrophages (TAMs) predominate and drive tumor growth, angiogenesis, and metastasis. Therapeutic strategies therefore focus on
Zhimei Liu, Yan Li, Jingchao Cao, Yefeng Qiu, Kun Yu, Shoulong Deng   +5 more
wiley   +1 more source

Polyamine Depletion by D,L-α-Difluoromethylornithine Inhibits Ewing Sarcoma Metastasis by Inducing Ferroptosis. [PDF]

Clin Cancer Res
Offenbacher R, Jackson KW, Hayashi M, Zhang J, Peng D, Tan Y, Stewart TM, Ciero P, Foley J, Casero RA, Cahan P, Loeb DM.   +11 more
europepmc   +1 more source

Breast Cancer: Molecular Pathogenesis, Targeted Therapy, Screening, and Prevention

MedComm, Volume 7, Issue 1, January 2026.
The review manuscript examines the molecular pathogenesis, screening, prevention advances, and evolving targeted therapies in breast cancer. It highlights the integration of AI and multiomics for precision prevention and personalized treatment, pointing toward future directions in equitable cancer care.
Huijun Lei, Jinzhen Fu, Wei Gu, Hongjin Qiao, Huixue Guo, Zijian Chen, San Ming Wang, Tianhui Chen   +7 more
wiley   +1 more source