Results 81 to 90 of about 164,541 (160)

Heterologous expression and biochemical characterization of a polyamine oxidase from Arabidopsis involved in polyamine back conversion

, 2006
Polyamine oxidase (PAO) is a flavin adenine dinucleotide-dependent enzyme involved in polyamine catabolism. Animal PAOs oxidize spermine (Spm), spermidine (Spd), and/or their acetyl derivatives to produce H2O2, an aminoaldehyde, and Spd or putrescine ...
ROSSI M. N, FEDERICO R., PEREZ AMADOR M. A, SACCUTI G, ANGELINI, Riccardo, ROSSI MN, Angelini R, TAVLADORAKI, Paraskevi, PEREZ AMADOR MA, POLTICELLI, Fabio   +9 more
core   +1 more source

NF-E2-related factor 1 suppresses the expression of a spermine oxidase and the production of highly reactive acrolein

Scientific Reports
Polyamines (putrescine, spermidine, and spermine) are among the most abundant intracellular small molecular metabolites, with concentrations at the mM level. The ratios of these three molecules remain constant under physiological conditions. Stress (i.e.
Tomoaki Hirakawa, Megumi Taniuchi, Yoko Iguchi, Sudarma Bogahawaththa, Kiko Yoshitake, Shanika Werellagama, Takeshi Uemura, Tadayuki Tsujita   +7 more
doaj   +1 more source

Polyamine oxidase activity and polyamine levels in human colorectal cancer and in normal surrounding mucosa.

, 1997
BACKGROUND: Polyamine oxidase (PAO) is an enzyme involved in the interconversion pathway of polyamines, compounds required for cell proliferation and differentiation. As the role of PAO in tumor growth is unclear, and no data about PAO activity in human
DI LEO, Alfredo, Linsalata M, Cavallini A   +2 more
core  

Polyamine pathway in neurological disorders: Potential therapeutic implications based on current evidences

Brain Research Bulletin
Polyamines (PAs) with a positive charge and low molecular weight, are a class of general biogenic amines that are involved in many important cellular processes, including maintaining nucleic acid stability, controlling ion channel activity, regulating ...
Mengqi Yan, Yingying Tang, Shuo Zhang, Li Yu, Cenglin Xu   +4 more
doaj   +1 more source

Polyamine analogues of propanediamine series inhibit prostate tumor cell growth and activate the polyamine catabolic pathway

Background/Aim. Polyamines are important for the growth of eukaryotic cells. At high levels, they promote proliferation, invasion and migration of tumour cells. Polyamine metabolism is an important new target for anticancer therapy.
Hilal A., Syatkin S.P., Sungrapova K.Y., Terentyev A.A., Korshunova A.Y., Neborak E.V., Ploskonos M.V., Sokuyev R.I., Blagonravov M.L.   +8 more
core   +1 more source

Evaluation of Alfalfa and Oat Polyamine Oxidase: One-Step Purification and Characteristics [PDF]

textThe polyamine oxidase activity of acetone powder from alfalfa was investigated. No enzyme activity was detected. Oat polyamine oxidase was purified in one step isoelectric point chromatography. This method is described in detail and discussed.
90242891, 127, Sakakibara, Yoko
core   +1 more source

A 30 A long U-shaped catalytic tunnel in the crystal structure of polyamine oxidase

, 1999
Background: Polyamines are essential for cell growth and differentiation; compounds interfering with their metabolism are potential anticancer agents. Polyamine oxidase (PAO) plays a central role in polyamine homeostasis.
Rodolfo Federico, FEDERICO R, CODA A, Riccardo Angelini, Paolo Ascenzi, CODA A., MATTEVI A., FEDERICO, Rodolfo, Alessandro Coda, Ascenzi P, ANGELINI R., BINDA C., ANGELINI R, ASCENZI, Paolo, Claudia Binda, ASCENZI P., Andrea Mattevi, BINDA C, CODA, ALESSANDRO, BINDA, CLAUDIA, MATTEVI, ANDREA   +20 more
core   +1 more source

Polyamine-Based Pt(IV) Prodrugs as Substrates for Polyamine Transporters Preferentially Accumulate in Cancer Metastases as DNA and Polyamine Metabolism Dual-Targeted Antimetastatic Agents

, 2019
Diverse platinum drug candidates have been designed to improve inhibitory potency and overcome resistance for orthotopic tumors. However, the antimetastatic properties have rarely been reported.
Sitong Liu (3750979), Shudi Guo (8118854), Yingguang Li, Peng George Wang (256049), Hanfang Liu (5775875), Jing Ma, Kexin Yue (8118851), Peng George Wang, Xiao Zhang (152326), Songqiang Xie, Yingguang Li (5775884), Zhuoqing Xi (5775878), Xiao Zhang, Kai Feng, Songqiang Xie (1750744), Kai Feng (502124), Jianing Liu, Chaojie Wang (2175530), Chaojie Wang, Zhuoqing Xi, Sitong Liu, Jing Ma (24574), Qi Ma (141685), Hanfang Liu, Kexin Yue, Linrong Li, Qi Ma, Shudi Guo, Linrong Li (7464398), Jianing Liu (140090)   +29 more
core   +2 more sources

Polyamine Metabolism in Brain Health and Disease

Neuropharmacology and Therapy
Polyamines, primarily spermidine and spermine, are small polycationic molecules essential for cell growth, signaling, and survival. Through electrostatic interactions with nucleic acids, lipids, and proteins, they regulate gene expression, organelle ...
Xianzun Tao, Tracey Nassuna, R. Grace Zhai   +2 more
doaj   +1 more source

Application of sucrose modulates the expressions of genes involved in proline and polyamine metabolism in maize seedlings exposed to drought

Biologia Plantarum, 2019
Sucrose, proline, and polyamines are compatible solutes accumulating in plant tissues and increasing cellular osmolarity under environmental stresses. These compatible solutes and hydrogen peroxide can function as signaling molecules in plants. There has
C. Altuntaş, A. Sezgin, M. Demiralay, R. Terzi, A. Sağlam, A. Kadioğlu   +5 more
doaj   +1 more source