Results 91 to 100 of about 36,402 (277)

Lactate and Lactylation in AKI‐to‐CKD: Epigenetic Regulation and Therapeutic Opportunities

Cell Proliferation, EarlyView.
ABSTRACT Lactate is not only a byproduct of glycolysis, but is also considered an energy source, gluconeogenic precursor, signalling molecule and protein modifier during the process of cellular metabolism. The discovery of lactylation reveals the multifaceted functions of lactate in cellular metabolism and opens new avenues for lactate‐related research.
Yi Hou, Dongwei Liu, Zuishuang Guo, Cien Wei, Fengyu Cao, Yue Xu, Qi Feng, Fengxun Liu   +7 more
wiley   +1 more source

Foetal disruptive brain injuries: Diagnosing the underlying pathogenetic mechanisms with cranial ultrasonography

Developmental Medicine &Child Neurology, EarlyView.
Abstract Antenatal destructive events affecting the central nervous system of the foetus lead to disruptive brain lesions that are often associated with impaired neurodevelopment. The pathogenesis of these lesions encompasses a range of causes, including haemorrhagic, embolic, or other vascular events; exposure to teratogens, such as drugs or substance
Ana Alarcón, Nuria Carreras, Tobias Muehlbacher, Dídac Casas‐Alba, Roberta Arena, Paola Roca‐Llabrés, Juan Navarro‐Morón, Linda S. de Vries, Paul Govaert, the EurUS.Brain group, Thais Agut, Roberta Arena, Ana Alarcón, Juan Arnáez, Marco Bartocci, Isabel Benavente‐Fernández, María Carmen Bravo, Fernando Cabañas, Nuria Carreras, Olivier Claris, Jeroen Dudink, Monica Fumagalli, Alfredo García‐Alix, Paul Govaert, Sandra Horsch, Simón Lubián, Tobias Muehlbacher, Alessandro Parodi, Adelina Pellicer, Luca Ramenghi, Charles C. Roehr, Simone Schwarz, Sylke Steggerda, Eva Valverde   +33 more
wiley   +1 more source

Developments in albuminuria testing: A key biomarker for detection, prognosis and surveillance of kidney and cardiovascular disease—A practical update for clinicians

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Albuminuria, the abnormal presence of albumin in urine, is a key marker of kidney damage and a strong predictor of kidney and cardiovascular outcomes. Its clinical significance has evolved from early historical observations to its current role in chronic kidney disease (CKD) detection, risk stratification and treatment monitoring.
Jelle M. Beernink, Dominique van Mil, Gozewijn D. Laverman, Hiddo J. L. Heerspink, Ron T. Gansevoort   +4 more
wiley   +1 more source

Clinical aspects of polycystic disease of the kidneys. [PDF]

, 1977
H. David Mitcheson, G. Williams, J E Castro   +2 more
openalex   +1 more source

Predictors of diabetic ketoacidosis in patients with insulin‐deficient diabetes phenotype initiating SGLT2 inhibitors

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims To identify predictors of diabetic ketoacidosis (DKA) in patients with an insulin‐deficient phenotype initiating sodium‐glucose cotransporter 2 inhibitor (SGLT2i) therapy. Materials and Methods This retrospective cohort study analysed data from 31 900 patients with diabetes aged 18–70 identified as having an insulin‐deficient phenotype ...
Anat Tsur, Gil Leibowitz, Matan J. Cohen, Avivit Cahn, Rena Pollack   +4 more
wiley   +1 more source

Adult type of polycystic disease of kidneys and liver presenting in childhood [PDF]

, 1974
B. G. Ockenden
openalex   +1 more source

The pathogenesis of polycystic kidney disease.

Histology and histopathology, 1995
Polycystic kidney disease (PKD) is a genetic or acquired disorder characterized by progressive distention of multiple tubular segments and manifested by fluid accumulation, growth of non-neoplastic epithelial cells and remodeling of the extracellular matrix resulting ultimately in some degree of renal functional impairment, with the potential for ...
Carone, F.A., Bacallao, R., Kanwar, Y.S.
openaire   +2 more sources

Prediction of major outcomes in patients with malignant hypertension using machine learning: A report from the West Birmingham malignant hypertension registry

European Journal of Clinical Investigation, EarlyView.
Malignant hypertension (MHT) is a rare, severe condition with high morbidity and mortality. Using data from 385 patients in the West Birmingham MHT Registry, this study evaluated nine machine learning (ML) algorithms to predict a composite outcome of all‐cause mortality/dialysis over a median 11‐year follow‐up.
Antonios A. Argyris, Hironori Ishiguchi, Yang Chen, Yalin Zheng, Alena Shantsila, Eduard Shantsila, D. Gareth Beevers, Gregory Y. H. Lip   +7 more
wiley   +1 more source

Congenital Hepatic Fibrosis and Polycystic Kidney Disease; Role of Porta-Caval Shunting and Transplantation in Three Patients [PDF]

, 1981
R J McGonigle, Alex P. Mowat, M. Bewick, E R Howard, Susan A. Snowden, Victor Parsons   +5 more
openalex   +1 more source

Emerging roles for integrated stress response signaling in homeostasis

The FEBS Journal, EarlyView.
Integrated stress response (ISR), an evolutionarily conserved eukaryotic stress‐adaptive program in eukaryotes, has also been implicated in homeostatic functions. This review covers a broad body of literature and presents several homeostatic functions of ISR in the absence of stress: (a) developmental processes (morphogenesis, differentiation, aging), (
Shyama Nandakumar, Lydia Grmai, Deepika Vasudevan   +2 more
wiley   +1 more source