Results 1 to 10 of about 24,760 (225)

Evolutionary Reprogramming of Acyltransferase Domains in Polyene Macrolide Pathways [PDF]

Microorganisms
The evolution of type I polyketide synthase (T1PKS) assembly lines remains poorly understood. Through systematic mining of polyene biosynthetic gene clusters, we identified a novel eurocidin biosynthetic pathway capable of producing identical compounds ...
Liran Zhang, Jinwei Ren, Chengyu Zhang, Lixin Zhang, Bin Wang, Jingyu Zhang   +5 more
doaj   +2 more sources

Engineered biosynthesis and characterization of disaccharide-pimaricin [PDF]

Microbial Cell Factories
Background Disaccharide polyene macrolides exhibit superior water solubility and significantly reduced hemolytic toxicity compared to their monosaccharide counterparts, making them promising candidates for safer antifungal therapeutics. In this study, we
Xiaoshan Zuo, Liqin Qiao, Yao Dong, Xing Jin, Zhongyuan Ren, Hao Cui   +5 more
doaj   +2 more sources

Polyene-Producing Streptomyces spp. From the Fungus-Growing Termite Macrotermes barneyi Exhibit High Inhibitory Activity Against the Antagonistic Fungus Xylaria

Frontiers in Microbiology, 2021
Fungus-growing termites are engaged in a tripartite mutualism with intestinal microbes and a monocultivar (Termitomyces sp.) in the fungus garden. The termites are often plagued by entomopathogen (Metarhizium anisopliae) and fungus garden is always ...
Jingjing Li, Moli Sang, Yutong Jiang, Jianhua Wei, Yulong Shen, Qihong Huang, Yaoyao Li, Yaoyao Li, Jinfeng Ni   +8 more
doaj   +1 more source

Polyenes in Medium Chain Length Polyhydroxyalkanoate (mcl-PHA) Biopolymer Microspheres with Reduced Toxicity and Improved Therapeutic Effect against Candida Infection in Zebrafish Model

Pharmaceutics, 2022
Immobilizing antifungal polyenes such as nystatin (Nys) and amphotericin B (AmB) into biodegradable formulations is advantageous compared to free drug administration providing sustained release, reduced dosing due to localized targeting and overall ...
Aleksandar Pavic, Zoran Stojanovic, Marina Pekmezovic, Đorđe Veljović, Kevin O’Connor, Ivana Malagurski, Jasmina Nikodinovic-Runic   +6 more
doaj   +1 more source

Amphotericin B and Other Polyenes—Discovery, Clinical Use, Mode of Action and Drug Resistance

Journal of Fungi, 2020
Although polyenes were the first broad spectrum antifungal drugs on the market, after 70 years they are still the gold standard to treat a variety of fungal infections. Polyenes such as amphotericin B have a controversial image.
Hans Carolus, Siebe Pierson, Katrien Lagrou, Patrick Van Dijck   +3 more
doaj   +1 more source

Stimulated Biosynthesis of an C10-Deoxy Heptaene NPP B2 via Regulatory Genes Overexpression in Pseudonocardia autotrophica

Frontiers in Microbiology, 2020
Polyene macrolides, such as nystatin A1, amphotericin B, and NPP A1, belong to a large family of valuable antifungal polyketide compounds that are typically produced by soil actinomycetes.
Heung-Soon Park, Hye-Jin Kim, Chi-Young Han, Hee-Ju Nah, Si-Sun Choi, Eung-Soo Kim   +5 more
doaj   +1 more source

Polyhydroxyalkanoate/Antifungal Polyene Formulations with Monomeric Hydroxyalkanoic Acids for Improved Antifungal Efficiency

Antibiotics, 2021
Novel biodegradable and biocompatible formulations of “old” but “gold” drugs such as nystatin (Nys) and amphotericin B (AmB) were made using a biopolymer as a matrix.
Marina Pekmezovic, Melina Kalagasidis Krusic, Ivana Malagurski, Jelena Milovanovic, Karolina Stępień, Maciej Guzik, Romina Charifou, Ramesh Babu, Kevin O’Connor, Jasmina Nikodinovic-Runic   +9 more
doaj   +1 more source

Screening and Isolation of a Novel Polyene-Producing Streptomyces Strain Inhibiting Phytopathogenic Fungi in the Soil Environment

Frontiers in Bioengineering and Biotechnology, 2021
Microbial-based eco-friendly biological substances are needed to protect crops from phytopathogenic fungi and replace toxic chemical fungicides that cause serious environmental issues.
Heung-Soon Park, Hee-Ju Nah, Seung-Hoon Kang, Si-Sun Choi, Eung-Soo Kim, Eung-Soo Kim   +5 more
doaj   +1 more source

The Discovery of Actinospene, a New Polyene Macrolide with Broad Activity against Plant Fungal Pathogens and Pathogenic Yeasts

Molecules, 2021
Phytopathogenic fungi infect crops, presenting a worldwide threat to agriculture. Polyene macrolides are one of the most effective antifungal agents applied in human therapy and crop protection. In this study, we found a cryptic polyene biosynthetic gene
Ying Tang, Cuiyang Zhang, Tianqi Cui, Ping Lei, Zhaohui Guo, Hailong Wang, Qingshu Liu   +6 more
doaj   +1 more source

A polyene macrolide targeting phospholipids in the fungal cell membrane. [PDF]

Nature
Deng Q, Li Y, He W, Chen T, Liu N, Ma L, Qiu Z, Shang Z, Wang Z.   +8 more
europepmc   +2 more sources