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Optimization of Ultrasonic-Assisted Extraction of Active Components and Antioxidant Activity from Polygala tenuifolia: A Comparative Study of the Response Surface Methodology and Least Squares Support Vector Machine [PDF]

Molecules, 2022
Dried roots of Polygala tenuifolia (YuanZhi in Chinese) are widely used in Chinese herbal medicine. These components in YuanZhi have significant anti-oxidation properties owing to high levels of 3,6’-disinapoylsucrose (DISS) and Polygalaxanthone III ...
Xuran Li, Simiao Chen, Jinghui Zhang, Li Yu, Weiyan Chen, Yuyan Zhang   +5 more
doaj   +2 more sources

Excavating Precursors from the Traditional Chinese Pair Herbs Polygala tenuifolia and Gastrodia elata: Synthesis, Anticonvulsant Activity Evaluation of 3,4,5-Trimethoxycinnamic Acid (TMCA) Peptide Analogs [PDF]

Pharmaceuticals
Background: Epilepsy comprises a range of disorders affecting the central nervous system (CNS) characterized by recurrent seizures, impacting approximately 60 million individuals globally.
Zefeng Zhao, Mengchen Lei, Yujun Bai, Haifa Qiao   +3 more
doaj   +2 more sources

Integrative network pharmacology, transcriptomics, and microbiomics elucidate the therapeutic mechanism of Polygala tenuifolia Willd water extract in chronic obstructive pulmonary disease [PDF]

Frontiers in Microbiology
BackgroundPolygala tenuifolia Willd (PT) is a plant with both medicinal and edible values. Traditionally, it has been used for sedation, enhancing cognition, resolving phlegm, and relieving cough.
Yiming An, Yiming An, Xiao Yu, Chao Wang, Xin Yu, Jingtong Zheng, Hongqiang Lin, Hongqiang Lin   +7 more
doaj   +2 more sources

Polygala tenuifolia Willd. Extract delays non-alcoholic fatty liver disease progression in rats via the COX2 and PERK-elF2α-ATF4 pathway [PDF]

Frontiers in Pharmacology
BackgroundNon-alcoholic fatty liver disease (NAFLD), a chronic liver disease posing a severe threat to human health, currently lacks specific therapeutic drugs. Our previous studies have demonstrated that Polygala tenuifolia Willd.
Zhiliang Sun, Zhongshi Zhou, Kezheng Liao, Yanju Liu, Yanyun Liu, Chaoyang Wang, Zhihua Zhang, Zhihua Zhang, Li Wen   +8 more
doaj   +2 more sources

Excavating Precursors from Herb Pairs Polygala tenuifolia and Acori tatarinowii: Synthesis and Anticonvulsant Activity Evaluation of 3,4,5-Trimethoxycinnamic Acid (TMCA) Piperazine Amide Derivatives [PDF]

Pharmaceuticals
Background: Epilepsy is a cluster of central nervous system (CNS) disorders identified by recurrent seizures, which affects about 60 million people around the world. In this research, a total of 40 types of 3,4,5-trimethoxycinnamic acid (TMCA) piperazine
Zefeng Zhao, Mengchen Lei, Yongqi Wang, Yujun Bai, Haifa Qiao   +4 more
doaj   +2 more sources

Pharmacometabolomics and mass spectrometry imaging approach to reveal the neurochemical mechanisms of Polygala tenuifolia [PDF]

Journal of Pharmaceutical Analysis
Polygala tenuifolia, commonly known as Yuanzhi (YZ) in Chinese, has been shown to possess anti-insomnia properties. However, the material basis and the mechanism underlying its sedative-hypnotic effects remain unclear.
Qian Li, Jinpeng Bai, Yuxue Ma, Yu Sun, Wenbin Zhou, Zhaoying Wang, Zhi Zhou, Zhonghua Wang, Yanhua Chen, Zeper Abliz   +9 more
doaj   +2 more sources

Extract of Polygala tenuifolia, Angelica tenuissima, and Dimocarpus longan improve skin wound healing in streptozotocin- induced diabetic mouse [PDF]

Frontiers in Pharmacology
ObjectiveChronic skin wounds caused by diabetes, peripheral artery disease, pressure ulcers, and venous insufficiency do not fully recover anatomically and functionally.
Hayan Jeong, Hyo-Jin Chong, Yejin Jo, Jungtae Na, Yeon Jae Jang, Su Young Moon, Jangho So, In Ho Jung, Ok Nam Park, Bong-Gun Ju   +9 more
doaj   +2 more sources

HMGR and CHS gene cloning, characterizations and tissue-specific expressions in Polygala tenuifolia Willd. [PDF]

PLoS ONE
Triterpenoid saponins and flavonoids have several pharmacological activities against P. tenuifolia. The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) and chalcone synthase (CHS) are the rate-limiting enzymes of triterpenoid saponin and flavonoid ...
Yang Liu, Xiaofang Ma, Fuying Mao, Jinmiao Qiu, Jingyi Bi, Xiaowei Li, Xian Gu, Yuguang Zheng, Yunsheng Zhao   +8 more
doaj   +2 more sources

The Protective Effects of Polygala tenuifolia and Tenuifolin on Corticosterone-Evoked Ferroptosis, Oxidative Stress, and Neuroinflammation: Insights from Molecular Dynamics Simulations and In Vitro Experiments [PDF]

Foods
Excessive stress is a well-established contributor to neurological damage, insomnia, and depression, imposing a significant burden on individuals and society. This underscores the urgent need for effective stress-relief strategies.
Chaoyi Xue, Zhiyong He, Maomao Zeng, Zhaojun Wang, Qiuming Chen, Fang Qin, Mingmin Chen, Hui Ye, Jie Chen   +8 more
doaj   +2 more sources

Avicularin and Senegenin Suppress TRPV3-Associated TSLP Expression in Human Keratinocytes [PDF]

Cells
Transient receptor potential vanilloid channel 3 (TRPV3) is a keratinocyte-expressed ion channel that regulates calcium signaling and thymic stromal lymphopoietin (TSLP) production, contributing to pruritic inflammatory skin diseases. Although avicularin
Han Bi Kim, Ji Young Um, Da Eun Song, Bo Young Chung, Chun Wook Park, Hye One Kim   +5 more
doaj   +2 more sources