Neuroprotective Effects and Mechanisms of Senegenin, an Effective Compound Originated From the Roots of Polygala Tenuifolia [PDF]
Frontiers in Pharmacology, 2022 Senegenin is the main bioactive ingredient isolated from the dried roots of Polygala tenuifolia Willd. In recent years, senegenin has been proved to possess a variety of pharmacological activities, such as anti-oxidation, anti-inflammation, anti ...
Zhe Chen, Yu Yang, Ying Han, Xijun Wang
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Polygala tenuifolia and Acorus tatarinowii in the treatment of Alzheimer’s disease: a systematic review and meta-analysis [PDF]
Frontiers in Pharmacology, 2023 Background: The complexity of Chinese medicine treatment for Alzheimer’s disease (AD) utilizing a multi-herb therapy makes the evidence in current studies insufficient. Herb pairs are the most fundamental form of multi-herb formulae.
Yuchen Zhang +5 more
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Chemical constituents from the aerial part of Polygala tenuifolia
Natural Product Research, 2021 Three new compounds, polygalapyrone A (1), tenuiside G (2) and polygalapyrrole A (3), together with two known compounds (4–5) were isolated by silica gel, ODS and preparative HPLC from the aerial part of Polygala tenuifolia. Their structures were elucidated by spectrum analysis and compared with findings from the literature.
Yan-Gang, Cheng +6 more
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UPLC/Q-TOF MS-based metabolomics and qRT-PCR in enzyme gene screening with key role in triterpenoid saponin biosynthesis of Polygala tenuifolia. [PDF]
PLoS ONE, 2014 BackgroundThe dried root of Polygala tenuifolia, named Radix Polygalae, is a well-known traditional Chinese medicine. Triterpenoid saponins are some of the most important components of Radix Polygalae extracts and are widely studied because of their ...
Fusheng Zhang +6 more
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Integrative network pharmacology, transcriptomics, and microbiomics elucidate the therapeutic mechanism of Polygala tenuifolia Willd water extract in chronic obstructive pulmonary disease [PDF]
Frontiers in MicrobiologyBackgroundPolygala tenuifolia Willd (PT) is a plant with both medicinal and edible values. Traditionally, it has been used for sedation, enhancing cognition, resolving phlegm, and relieving cough.
Yiming An +7 more
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Four New Phenones from the Cortexes of Polygala tenuifolia
Chemical and Pharmaceutical Bulletin, 2005 From the 95% EtOH extract of the cortexes of Polygala tenuifolia, four new phenones and three known xanthones were isolated. The structures of the four new phenones were identified as 4-O-[alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranosyl]-2-hydroxyl-6-methoxybenzophenone (tenuiphenone A, 1), 3,5-di-C-beta-glucopyranosyl-2,4,6,3 ...
Jiang, Yong, Tu, Pengfei
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Polygala tenuifolia Willd. Extract delays non-alcoholic fatty liver disease progression in rats via the COX2 and PERK-elF2α-ATF4 pathway [PDF]
Frontiers in PharmacologyBackgroundNon-alcoholic fatty liver disease (NAFLD), a chronic liver disease posing a severe threat to human health, currently lacks specific therapeutic drugs. Our previous studies have demonstrated that Polygala tenuifolia Willd.
Zhiliang Sun +8 more
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Mitochondrial DNA. Part B. Resources, 2021 Polygala crotalarioides Buch.-Ham. ex DC. (Polygalaceae) is a perennial herbaceous plant widely distributed in southwest China. Its chloroplast genome sequence was obtained using Illumina NovaSeq sequencing technology, and then was assembled, annotated ...
Jiayu Ma +5 more
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Excavating Precursors from Herb Pairs Polygala tenuifolia and Acori tatarinowii: Synthesis and Anticonvulsant Activity Evaluation of 3,4,5-Trimethoxycinnamic Acid (TMCA) Piperazine Amide Derivatives [PDF]
PharmaceuticalsBackground: Epilepsy is a cluster of central nervous system (CNS) disorders identified by recurrent seizures, which affects about 60 million people around the world. In this research, a total of 40 types of 3,4,5-trimethoxycinnamic acid (TMCA) piperazine
Zefeng Zhao +4 more
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Extract of Polygala tenuifolia, Angelica tenuissima, and Dimocarpus longan improve skin wound healing in streptozotocin- induced diabetic mouse [PDF]
Frontiers in PharmacologyObjectiveChronic skin wounds caused by diabetes, peripheral artery disease, pressure ulcers, and venous insufficiency do not fully recover anatomically and functionally.
Hayan Jeong +9 more
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