Effect of Combination Electroacupuncture and Tenuigenin on the Migration and Differentiation of Mesenchymal Stem Cells following Ischemic Stroke [PDF]
Journal of Pharmacopuncture, 2023 Objectives: Since stroke is a serious health issue, novel therapeutic strategies are required. In a mouse model of ischemic stroke, this study analyzed the potential of electroacupuncture (EA) and tenuigenin (TE) to improve the efficacy of human ...
Jae Ho Lee +2 more
doaj +4 more sources
Tenuigenin protects dopaminergic neurons from inflammation via suppressing NLRP3 inflammasome activation in microglia [PDF]
Journal of Neuroinflammation, 2017 Background Emerging evidence indicates that nod-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome-induced inflammation plays a crucial role in the pathogenesis of Parkinson’s disease (PD).
Zheng Fan +5 more
doaj +5 more sources
Tenuigenin regulates succinylation via SIRT5 for suppressing the tumorigenicity of hepatocellular carcinoma cells [PDF]
Frontiers in PharmacologyIntroductionTenuigenin (TEN) is an active component extracted from the Polygala tenuifolia root and has been reported to show anti-insomnia, anti- amnesia, neuroprotective, and anti-inflammatory effects.
Yifan Yan +3 more
doaj +3 more sources
Investigating the effect of tenuigenin on LPS-induced HPMEC dysfunction by inhibiting SRC activation based on network pharmacology and molecular docking [PDF]
HereditasBackground Adult pneumonia is an infectious lung disease caused by bacteria, viruses, or other microorganisms and exhibits some degree of contagion.
Jingchao Chen +4 more
doaj +4 more sources
Neuroprotective effects of tenuigenin on neurobehavior, oxidative stress, and tau hyperphosphorylation induced by intracerebroventricular streptozotocin in rats [PDF]
Brain Circulation, 2018 BACKGROUND: Tenuigenin (TEN), a major active component of the Chinese herb Polygala tenuifolia root, has been used to improve memory and cognitive function in Traditional Chinese Medicine for centuries.
Xiao-Bo Huang +5 more
doaj +5 more sources
The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases [PDF]
Frontiers in Aging, 2023 The pathophysiology of different neurodegenerative illnesses is significantly influenced by the polarization regulation of microglia and macrophages.
Samar F. Darwish +5 more
doaj +2 more sources
Polygala tenuifolia: a source for anti-Alzheimer’s disease drugs [PDF]
Pharmaceutical Biology, 2020 Context Alzheimer’s disease (AD) is a chronic neurodegenerative disease that originates from central nervous system lesions or recessions. Current estimates suggest that this disease affects over 35 million people worldwide.
Xinxin Deng +8 more
doaj +2 more sources
Saponin components in Polygala tenuifolia as potential candidate drugs for treating dementia [PDF]
Frontiers in PharmacologyObjectiveThis study aims to elucidate the intervention effects of saponin components from Polygala tenuifolia Willd (Polygalaceae) on dementia, providing experimental evidence and new insights for the research and application of saponins in the field of ...
Songzhe Li +5 more
doaj +2 more sources
Protective role of tenuigenin on sepsis-induced acute kidney injury in mice. [PDF]
Exp Ther Med, 2017 Acute kidney injury (AKI) is a severe complication of sepsis, which largely contributes to the associated high mortality rate. Tenuigenin (TNG) is a natural product isolated from Polygala tenuifolia root, which possesses anti-inflammatory and anti-oxidant properties.
Xu Y, Jiang Y, Gai W, Yu B.
europepmc +4 more sources
Combined application of tenuigenin and β-asarone improved the efficacy of memantine in treating moderate-to-severe Alzheimer's disease. [PDF]
Drug Des Devel Ther, 2018 Alzheimer's disease (AD) is a slowly progressive neurodegenerative disease which cannot be cured at present. The aim of this study was to assess whether the combined application of β-asarone and tenuigenin could improve the efficacy of memantine in treating moderate-to-severe AD.One hundred and fifty-two patients with moderate-to-severe AD were ...
Chang W, Teng J.
europepmc +6 more sources