Results 11 to 20 of about 240 (114)
Chinese Journal of Contemporary Neurology and Neurosurgery, 2014 Objective To investigate the effects of tenuigenin (TEN) on expression of brain-derived neurotrophic factor (BDNF), and its receptor tyrosine protein kinase B (TrkB) in the hippocampal CA1 region of Alzheimer's disease (AD) model rats.
Wei-rong CHEN +3 more
doaj +2 more sources
Protective role of tenuigenin on sepsis-induced acute kidney injury in mice. [PDF]
Exp Ther Med, 2017 Acute kidney injury (AKI) is a severe complication of sepsis, which largely contributes to the associated high mortality rate. Tenuigenin (TNG) is a natural product isolated from Polygala tenuifolia root, which possesses anti-inflammatory and anti-oxidant properties.
Xu Y, Jiang Y, Gai W, Yu B.
europepmc +5 more sources
Chinese Journal of Contemporary Neurology and Neurosurgery, 2014 doi: 10.3969/j.issn.1672-6731.2014.08 ...
Wei-rong CHEN
doaj +2 more sources
Tenuigenin promotes the osteogenic differentiation of bone mesenchymal stem cells in vitro and in vivo. [PDF]
Cell Tissue Res, 2017 Osteoporosis, which is a systemic skeletal disease characterized by low bone mineral density and microarchitectural deterioration of bone quality, is a global and increasing public health problem. Recent studies have suggested that Tenuigenin (TEN), a class of native compounds with numerous biological activities such as anti-resorptive properties ...
Jiang HJ +11 more
europepmc +7 more sources
Tenuigenin Protects Dopaminergic Neurons from Inflammation‐Mediated Damage Induced by the Lipopolysaccharide [PDF]
CNS Neuroscience & Therapeutics, 2012 SummaryBackgroundParkinson's disease (PD) is a neurodegenerative disorder characterized by progressive death of dopaminergic neurons in the substantia nigra pars compacta (SNpc).AimsTo study if tenuigenin (TEN), the main active component of Polygala tenuifolia, can protect dopaminergic neurons from inflammation‐mediated damage in vivo.MethodsWe ...
Hui-Li, Yuan +6 more
openaire +3 more sources
NeuroReport, 2018 Alzheimer's disease (AD) is a progressive neurodegenerative disease that has no cure at present. This study was carried out to evaluate whether the combination of β-asarone and tenuigenin could improve the efficacy of memantine as a monotherapy in the treatment of AD. Patients with AD were recruited and assigned to two groups.
Haiying, Dong +3 more
openaire +3 more sources
Natural Product ResearchTenuigenin is a kind of the main active ingredients in roots of Polygala tenuifolia Willd. (a species in the genus Polygala, family Polygalaceae) and forsythoside A (FA) is one of the main active ingredients of Forsythia suspensa (Thunb.) Vahl. (a species in the genus Forsythia, family Meliaceae).
Guocui, Liang +3 more
openaire +3 more sources
Determination of Senegenin and Tenuifolin in Mouse Blood by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry and Their Pharmacokinetics. [PDF]
Int J Anal Chem, 2022 An ultra‐high performance liquid chromatography‐tandem mass spectrometry (UPLC‐MS/MS) method for the determination of senegenin and tenuifolin in mouse blood was developed. The pharmacokinetics of senegenin and tenuifolin in mice after intravenous (5 mg/kg) and oral (60 mg/kg) administration were studied, and the absolute bioavailability was calculated.
Shen X, Dai X, He Y, Wen C, Zhang Q.
europepmc +2 more sources
Effects of Herbs and Derived Natural Products on Lipopolysaccharide-Induced Toxicity: A Literature Review. [PDF]
Oxid Med Cell Longev, 2023 Introduction. Oxidative stress (OS) during inflammation can increase inflammatory responses and damage tissue. Lipopolysaccharide (LPS) can induce oxidative stress and inflammation in several organs. Natural products have several biological activities including anti‐inflammatory, antioxidant, and immunoregulatory properties.
Kianmehr M +3 more
europepmc +2 more sources
The Positive Role and Mechanism of Herbal Medicine in Parkinson's Disease. [PDF]
Oxid Med Cell Longev, 2021 Parkinson’s disease (PD) is a complex neurodegenerative disease, manifested by the progressive functional impairment of the midbrain nigral dopaminergic neurons. Due to the unclear underlying pathogenesis, disease‐modifying drugs for PD remain elusive.
Yin R +7 more
europepmc +2 more sources