Results 11 to 20 of about 234 (110)
Tenuigenin promotes the osteogenic differentiation of bone mesenchymal stem cells in vitro and in vivo. [PDF]
Cell Tissue Res, 2017 Osteoporosis, which is a systemic skeletal disease characterized by low bone mineral density and microarchitectural deterioration of bone quality, is a global and increasing public health problem. Recent studies have suggested that Tenuigenin (TEN), a class of native compounds with numerous biological activities such as anti-resorptive properties ...
Jiang HJ +11 more
europepmc +5 more sources
Tenuigenin protects dopaminergic neurons from inflammation-mediated damage induced by the lipopolysaccharide. [PDF]
CNS Neurosci Ther, 2012 SummaryBackgroundParkinson's disease (PD) is a neurodegenerative disorder characterized by progressive death of dopaminergic neurons in the substantia nigra pars compacta (SNpc).AimsTo study if tenuigenin (TEN), the main active component of Polygala tenuifolia, can protect dopaminergic neurons from inflammation‐mediated damage in vivo.MethodsWe ...
Yuan HL +6 more
europepmc +5 more sources
Chinese Journal of Contemporary Neurology and Neurosurgery, 2014 Objective To investigate the effects of tenuigenin (TEN) on expression of brain-derived neurotrophic factor (BDNF), and its receptor tyrosine protein kinase B (TrkB) in the hippocampal CA1 region of Alzheimer's disease (AD) model rats.
Wei-rong CHEN +3 more
doaj +2 more sources
Chinese Journal of Contemporary Neurology and Neurosurgery, 2014 doi: 10.3969/j.issn.1672-6731.2014.08 ...
Wei-rong CHEN
doaj +2 more sources
Drug Design, Development and Therapy, 2018 Wenguang Chang,1 Junfang Teng2 1Department of Neurology, Xinxiang Central Hospital, Xinxiang, Henan, People’s Republic of China; 2Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Henan, People’s Republic of ...
Chang W, Teng J
doaj +1 more source
Natural Product ResearchTenuigenin is a kind of the main active ingredients in roots of Polygala tenuifolia Willd. (a species in the genus Polygala, family Polygalaceae) and forsythoside A (FA) is one of the main active ingredients of Forsythia suspensa (Thunb.) Vahl. (a species in the genus Forsythia, family Meliaceae).
Guocui, Liang +3 more
openaire +3 more sources
Biomedicine and Pharmacotherapy, 2023 Sleep disturbances are commonly non-motor symptoms in Parkinson's diseases (PD). However, standard dopamine replacement therapies for the treatment of motor symptoms often prove inadequate in combating sleep disturbances. Previous studies conducted by our research group have reported the neuroprotective effects of tenuigenin, a natural extract from ...
Fenqin Xue, Xiaomin Wang
exaly +3 more sources
Tenuigenin exhibits protective effects against LPS-induced acute kidney injury via inhibiting TLR4/NF-κB signaling pathway [PDF]
European Journal of Pharmacology, 2016 Tenuigenin (TNG) has been reported to have various pharmacological activities, such as anti-oxidative and anti-inflammatory activities. However, the protective effects of TNG on lipopolysaccharides (LPS)-induced acute kidney injury (AKI) are still not clear.
Haiyan Fu +2 more
exaly +3 more sources
Determination of Senegenin and Tenuifolin in Mouse Blood by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry and Their Pharmacokinetics. [PDF]
Int J Anal Chem, 2022 An ultra‐high performance liquid chromatography‐tandem mass spectrometry (UPLC‐MS/MS) method for the determination of senegenin and tenuifolin in mouse blood was developed. The pharmacokinetics of senegenin and tenuifolin in mice after intravenous (5 mg/kg) and oral (60 mg/kg) administration were studied, and the absolute bioavailability was calculated.
Shen X, Dai X, He Y, Wen C, Zhang Q.
europepmc +2 more sources
Effects of Herbs and Derived Natural Products on Lipopolysaccharide-Induced Toxicity: A Literature Review. [PDF]
Oxid Med Cell Longev, 2023 Introduction. Oxidative stress (OS) during inflammation can increase inflammatory responses and damage tissue. Lipopolysaccharide (LPS) can induce oxidative stress and inflammation in several organs. Natural products have several biological activities including anti‐inflammatory, antioxidant, and immunoregulatory properties.
Kianmehr M +3 more
europepmc +2 more sources