Results 11 to 20 of about 169 (141)
Design and Synthesis of Conformationally Diverse Pyrimidine-Embedded Medium/Macro- and Bridged Cycles via Skeletal Transformation [PDF]
Frontiers in Chemistry, 2022 The rigidity and flexibility of small molecules are complementary in 3-dimensional ligand-protein interaction. Therefore, the chemical library with conformational diversity would be a valuable resource for investigating the influence of skeletal ...
Yoona Choi +3 more
doaj +2 more sources
An Easy Access to Furan-Fused Polyheterocyclic Systems [PDF]
Molecules, 2022 Nitrostilbenes characterized by two different or differently substituted aryl moieties can be obtained from the initial ring-opening of 3-nitrobenzo[b]thiophene with amines. Such versatile building blocks couple the well-recognized double electrophilic reactivity of the nitrovinyl moiety (addition to the double bond, followed by, e.g., intramolecular ...
Alice Benzi +6 more
openaire +5 more sources
Desymmetrization of Pibrentasvir for Efficient Prodrug Synthesis [PDF]
Chem Sci, 2021 A novel and practical desymmetrization tactic is described to access a new class of pibrentasvir prodrugs. The homotopic benzimidazoles of pibrentasvir (PIB) are differentiated via a one-pot di-Boc/mono-de-Boc selective N-Boc protection and formaldehyde ...
Jan E., Waters +8 more
core +2 more sources
Palladium‐Catalyzed Dual Csp2─Csp3 Bond Formation: A Versatile Platform for the Synthesis of Benzo‐Fused Heterocycles [PDF]
Advanced Science, Volume 12, Issue 25, July 3, 2025.Pd(II)/Cu(I) co‐catalyzed dual Csp2─Csp3 bonds construction from unactivated alkenes and arylsulfonyl chlorides to access benzo‐fused heterocycles with high efficiency and chemoselectivity. Abstract Transition‐metal‐catalyzed transformations offer a powerful approach to rapidly synthesize complex benzo‐fused heterocycles, crucial for drug and material ...
Jiahui Huang +9 more
wiley +2 more sources
Iodine/Palladium Approaches to the Synthesis of Polyheterocyclic Compounds [PDF]
The Journal of Organic Chemistry, 2010 A simple, straightforward strategy for the synthesis of polyheterocyclic compounds (PHCs) is reported, which involves iterative cycles of palladium-catalyzed Sonogashira coupling, followed by iodocyclization using I(2) or ICl. A variety of heterocyclic units, including benzofurans, benzothiophenes, indoles, and isocoumarins, can be efficiently ...
Saurabh, Mehta, Richard C, Larock
openaire +3 more sources
Synthesis of BODIPY-pyrrolo[3,4-b]pyridin-5-ones via Ugi-Zhu/cascade reactions and studies of fluorescence response toward viscosity [PDF]
Frontiers in ChemistryA series of seven new meso-phenyl BODIPY-pyrrolo[3,4-b]pyridin-5-one conjugates were synthesized in one experimental step by using a Sc(III)-catalyzed Ugi-Zhu three-component reaction coupled to a cascade sequence (aza Diels-Alder/N-acylation ...
Julio C. Flores-Reyes +8 more
doaj +2 more sources
Green Synthesis and Catalysis, 2023 Disclosed herein is a novel Rh/Ag co-catalyzed SNH directed C–H activation and C–H/N–H bond functionalization protocol of free NH-sulfoximines with hypervalent iodonium ylides.
Jiapian Huang +4 more
doaj +1 more source
Synthesis of 4‐imidoyl‐, 4‐oxiranyl‐ and 4‐propargyloxyphenyl‐substituted β‐lactam building blocks
, 2023 In this study, the preparation of 4-imidoyl-, 4-oxiranyl-, and 4-propargyloxyphenyl-substituted beta-lactams as versatile building blocks in heterocyclic chemistry was realized.
Stevens, ChristianCA05LA248010006314660000-0003-4393-5327F43D8414-F0ED-11E1-A9DE-61C894A0A6B4 +8 more
core +2 more sources