Results 31 to 40 of about 169 (141)

Broad‐Spectrum Antiviral Agents against SARS‐CoV‐2 Variants Inhibit the Conserved Viral Protein Nsp1–RNA Interaction

Angewandte Chemie, Volume 136, Issue 47, November 18, 2024.
The demand for robust antiviral approaches is underscored by the continued COVID‐19 spread. SARS‐CoV‐2 Nsp1, highly conserved among SARS‐CoV‐2 variants, plays a pivotal role in controlling host protein expression and viral RNA translation. A small‐molecule Nsp1 inhibitor exhibited antiviral activity against various sarbecoviruses, signifying a ...
Wan Gi Byun, Minha Lee, Meehyun Ko, Ji Hyae Lee, Sihyeong Yi, JinAh Lee, Seungtaek Kim, Seung Bum Park   +7 more
wiley   +2 more sources

7,7′-(1,4-Phenylene)bis(2-benzyl-3-(3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one)

Molbank
The multicomponent synthesis of a novel and highly symmetric polyheterocycle based on the pyrrolo[3,4-b]pyridin-5-one core incorporating the privileged tetrahydroisoquinoline moiety is described.
Roberto E. Blanco-Carapia, Alejandro Islas-Jácome, Eduardo González-Zamora   +2 more
doaj   +1 more source

Multicomponent Synthesis of Fluorine‐Containing Bioactive Compounds and Drugs

European Journal of Organic Chemistry, Volume 28, Issue 38, October 15, 2025.
Multicomponent reactions are robust synthetic tools to assamble complex polyheterocycles and other interesting molecular architectures with potential application in medicinal chemistry, including their fluorine‐containing analogues. Fluorine atoms placed strategically into bioactive molecules often enhance essential pharmacokinetic parameters like ...
Ivette Morales‐Salazar, Perla Islas‐Jácome, Leonardo D. Herrera‐Zuñiga, Samuel Couve‐Bonnaire, Philippe Jubault, Eduardo González‐Zamora, Jean‐Philippe Bouillon, Alejandro Islas‐Jácome   +7 more
wiley   +1 more source

Multicomponent Synthesis of the New Compound 2-Benzyl-6-(3-((7-chloroquinolin-4-yl)amino)propyl)-3-morpholino-7-(4-pyridin-2-yl)phenyl)-6,7-dihidro-5H-pyrrolo[3,4-b]pyridin-5-one

Chemistry Proceedings
The combination of multicomponent reactions with post-transformation processes is a powerful strategy for the rapid synthesis of structurally complex polyheterocycles.
Roberto E. Blanco-Carapia, Rodolfo Alonso-Pérez, Alejandro Islas-Jácome, Eduardo Gonzalez-Zamora   +3 more
doaj   +1 more source

ELECTROOPTICAL PROPERTIES OF THIN FILMS OF POLYHETEROCYCLES

Le Journal de Physique Colloques, 1983
Some conducting polyheterocycles prepared by electroinitiated polymerization as thin films on electrodes change color reversibly when they are electrochemically cycled. As an example, polypyrrole is synthetized in an oxidized form and may be reduced reversibly between 0 and - 0,7 volt vs SCE.
Gazard, M., Dubois, J, Champagne, M., Garnier, F., Tourillon, G.   +4 more
openaire   +1 more source

One‐Pot Three‐Component Coupling Access to Indolizine‐Pyrrolodiazepine Hybrid Structures

Asian Journal of Organic Chemistry, Volume 14, Issue 6, June 2025.
One‐pot three‐component coupling of pyridine‐2‐acetonitrile, N‐substituted pyrrole‐2‐carboxaldehyde, and TMSCN in the presence of DBU allowed facile access to a novel indolizine‐pyrrolodiazepine hybrid structure via a domino aldol condensation‐Michael addition‐cycloisomerization‐imine formation process enabling sequential construction of two ...
Sunhee Lee, Seonghyeon Nam, Ikyon Kim
wiley   +1 more source

Diastereoselective One-Pot Tandem Synthesis of Chromenopyridodiazepinones through 1,4- and 1,6-Aza-Conjugate Additions/Heterocyclizations

, 2018
We report an efficient one-pot synthesis of a novel series of chromenopyridodiazepinone polyheterocycles by a catalyst-free nucleo­philic addition of ethane-1,2-diamine to (E,E)-3-[3-(2-hydroxyphenyl)-3-oxoprop-1-en-1-yl]-2-styrylchromones at room ...
Ricardo Mendes, Khaldoun Bachari, Oualid Talhi, Nadia Taibi, Ridha Hassaine, Artur Silva, Fillipe Almeida Paz, Abdelghani Bouchama   +7 more
core   +1 more source

Complexity-Building ESIPT-Assisted Synthesis of Fused Polyheterocyclic Sulfonamides

Molecules, 2023
Excited State Intramolecular Proton Transfer (ESIPT), originally discovered and explored in depth in a number of extensive photophysical studies, is more recently rediscovered as a powerful synthetic tool, offering rapid access to complex polyheterocycles. In our prior work we have employed ESIPT in aromatic o-keto amines and amides, leading to diverse
Srinivas Beduru, Andrei G. Kutateladze
openaire   +3 more sources

γ‐Terpinene: Biorenewable Reductant for the Molybdenum‐Catalyzed Reduction of Sulfoxides, N‐Oxides and Nitroarenes

Advanced Synthesis &Catalysis, Volume 367, Issue 9, May 6, 2025.
Abstract A molybdenum‐catalyzed deoxygenation of sulfoxides, pyridine and quinoline N‐oxides, N‐hydroxybenzotriazoles, as well as the reduction of nitroarenes to anilines, has been developed using monocyclic terpenes such as γ‐terpinene as an environmentally benign hydrogen surrogate.
Raquel Hernández‐Ruiz, Marta Solas, Samuel Suárez‐Pantiga, María R. Pedrosa, Roberto Sanz   +4 more
wiley   +1 more source

Palladium‐Catalyzed [3+2+2] Cycloaddition Between Carbonyl‐Tethered Alkylidenecyclopropanes and Isocyanates

Helvetica Chimica Acta, Volume 108, Issue 5, May 2025.
Abstract Carbonyl‐tethered alkylidenecyclopropanes can react with aryl isocyanates in presence of Pd(0)‐phosphoramidite catalysts to give seven‐membered heterobicyclic products in a formal [3+2+2] cycloaddition process. The reaction involves the formation of a palladium π‐allyl complex intermediate (A), which behaves as a formal 1,5‐dipole, and can be ...
Ricardo Rodiño, Jose L. Mascareñas, Fernando López   +2 more
wiley   +1 more source