Results 121 to 130 of about 2,197 (135)

Human exposure to polyhexamethylene guanidine phosphate from humidifiers in residential settings: Cause of serious lung disease

Toxicology and Industrial Health, 2017
Exposure to the humidifier disinfectant, polyhexamethylene guanidine phosphate (PHMG), in mists generated from ultrasonic humidifiers was studied in a simulation chamber and apartment rooms. PHMG is suspected as a causative agent of lung disease in Korea residences.
Ji Hyun, Lee, Il Je, Yu
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Metabolomic study on bleomycin and polyhexamethylene guanidine phosphate-induced pulmonary fibrosis mice models

Metabolomics, 2019
Polyhexamethylene guanidine phosphate (PHMG) has been used as a disinfectant and biocide, and was known to be harmless and non-toxic. However, in 2011, PHMG used as a humidifier disinfectant was reported to be associated with lung diseases, such as, fibrosis in the toxicant studies on pulmonary fibrosis by PHMG.
Chan Seo, Sung‐Hwan Kim, Hyeon-Seong Lee, Moongi Ji, Jeuk Min, Young-Jin Son, In-Hyeon Kim, Kyuhong Lee, M. Paik   +8 more
semanticscholar   +3 more sources

Prediction of the skin sensitization potential of polyhexamethylene guanidine phosphate, oligo(2-(2-ethoxy)ethoxyethyl) guanidinium chloride, triclosan, and mixtures of these compounds with the excipient propylene glycol through the local lymph node assay: BrdU-FCM

Toxicology and Industrial Health, 2019
The guanidine family of antimicrobial agents, which includes polyhexamethylene guanidine phosphate (PHMG) and oligo(2-(2-ethoxy)ethoxyethyl) guanidinium chloride (PGH), and chlorophenol biocidal chemicals such as 2,4,4′-trichloro-2′-hydroxydiphenyl ether
Ravi Gautam, Jihun Jo, Manju Acharya
exaly   +2 more sources

Akt and Notch pathways mediate polyhexamethylene guanidine phosphate-induced epithelial-mesenchymal transition via ZEB2.

Toxicology and Applied Pharmacology, 2019
Polyhexamethylene guanidine phosphate (PHMG-p), an antimicrobial additive, was used as a humidifier disinfectant in Korea and caused severe lung injuries, including lung fibrosis, in hundreds of victims.
M. Jeong, Ha Ryong Kim, Y. Park, K. Chung   +3 more
semanticscholar   +3 more sources

Polyhexamethylene guanidine phosphate induces pyroptosis via reactive oxygen species-regulated mitochondrial dysfunction in bronchial epithelial cells.

Toxicology
Pyroptosis is a form of programmed cell death characterized by gasdermin (GSDM)-mediated pore formation in the cell membrane, resulting in the release of pro-inflammatory cytokines and cellular lysis.
Jun Young Park, Ji-Hee Kim, Chan Ho Park, Sung-Hwan Kim, In-Hyeon Kim, Won Gil Cho   +5 more
semanticscholar   +3 more sources

Integration of transcriptomics, proteomics and metabolomics identifies biomarkers for pulmonary injury by polyhexamethylene guanidine phosphate (PHMG-p), a humidifier disinfectant, in rats

Archives of Toxicology, 2020
Polyhexamethylene guanidine phosphate (PHMG-p) was used as a humidifier disinfectant in Korea. PHMG induced severe pulmonary fibrosis in Koreans. The objective of this study was to elucidate mechanism of pulmonary toxicity caused by PHMG-p in rats using multi-omics analysis.
Jung Dae Lee, H. Kim, Keunsoo Kang, H. Jeong, M. Song, I. Tae, S. Lee, Hae Ri Kim, Kyuhong Lee, Sehyun Chae, D. Hwang, Suhkmann Kim, H. Kim, Kyu-Bong Kim, B. Lee   +14 more
semanticscholar   +3 more sources

Toxic responses to polyhexamethylene guanidine phosphate in cytoplasmic organelles

Toxicology Letters, 2017
In Jae Bang, Mi Ho Jeong, So Hee Yoo, Eun Hye Jang, Ha Ryong Kim   +4 more
openaire   +2 more sources

P21-29 Assessment of lung function changes in mice exposed to polyhexamethylene guanidine phosphate

Toxicology Letters
S. Jeong, H. Lee, Y.H. Park, Y. Nam, J. Kim, Y. Lee, J. Choi, S.A. Park, Y.-W. Baek, J. Lee   +9 more
semanticscholar   +2 more sources

P13-02 Polyhexamethylene guanidine phosphate induces lung fibrosis and cancer via the TAK1-related signaling pathway

Toxicology Letters
H. Lee, S. Jeong, Y.-W. Baek, J. Lee, C. Kim, J.K. Sa, J.Y. Lee, Y. Lee, Y. Nam, J. Kim, J. Choi, S.A. Park, J. Kim, Y.H. Park, J. Lim, Y. Kim, E. Park   +16 more
semanticscholar   +2 more sources

P20-10 A new murine liver fibrosis model induced by polyhexamethylene guanidine-phosphate

Toxicology Letters, 2022
K.T. Nam, M. Kim, S. Hur, K.H. Kim, Y. Cho, K. Kim, H.R. Kim, K.-M. Lim   +7 more
openaire   +1 more source