Results 131 to 140 of about 635 (158)

Mechanistic Insights on Metformin and Arginine Implementation as Repurposed Drugs in Glioblastoma Treatment. [PDF]

Int J Mol Sci
Barciszewska AM, Belter A, Barciszewski JF, Gawrońska I, Giel-Pietraszuk M, Naskręt-Barciszewska MZ.   +5 more
europepmc   +1 more source

Comparison of Anticancer Effects of Histone Deacetylase Inhibitors CG-745 and Suberoylanilide Hydroxamic Acid in Non-small Cell Lung Cancer. [PDF]

Tuberc Respir Dis (Seoul)
Kim HJ, An UR, Yoon HJ, Lim H, Hwang KE, Kim YS, Kim HR.   +6 more
europepmc   +1 more source

Differential toxicity of polyhexamethylene guanidine phosphate administered through intravenous injection and intratracheal instillation in Sprague-Dawley rats

Food and Chemical Toxicology
Se-Woong Park, In-Sik Shin, Sung-Hwan Kim, Han Na Suh   +3 more
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Recent Advances in Paper Conservation Using Nanocellulose and Its Composites. [PDF]

Molecules
Jiang M, Yao J, Guo Q, Yan Y, Tang Y, Yang Y.   +5 more
europepmc   +1 more source

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Polyhexamethylene guanidine phosphate-induced necrosis may be linked to pulmonary fibrosis

Toxicology Letters, 2022
Following the humidifier disinfectant incident in Korea, polyhexamethylene guanidine phosphate (PHMG-P) has been used to establish lung fibrosis model animals. Herein, we investigated time-dependent changes after a single PHMG-P instillation (22 μg/lung) to identify the underlying pathogenesis and immune response involved in PHMG-P-induced lung ...
Min-Sung, Kang, Sung-Hwan, Kim, Mi-Jin, Yang, Hyeon-Young, Kim, In-Hyeon, Kim, Jeong Won, Kang, Hye-Sook, Choi, Seung-Woo, Jin, Eun-Jung, Park   +8 more
openaire   +4 more sources

Polyhexamethylene guanidine phosphate aerosol particles induce pulmonary inflammatory and fibrotic responses

Archives of Toxicology, 2015
Polyhexamethylene guanidine (PHMG) phosphate was used as a disinfectant for the prevention of microorganism growth in humidifiers, without recognizing that a change of exposure route might cause significant health effects. Epidemiological studies reported that the use of humidifier disinfectant containing PHMG-phosphate can provoke pulmonary fibrosis ...
Ha Ryong, Kim, Kyuhong, Lee, Chang We, Park, Jeong Ah, Song, Da Young, Shin, Yong Joo, Park, Kyu Hyuck, Chung   +6 more
openaire   +4 more sources

A humidifier disinfectant biocide, polyhexamethylene guanidine phosphate, inhalation exposure during pregnancy induced toxicities in rats

Journal of Hazardous Materials, 2021
Biocides are widely used for their effective antiseptic and disinfectant properties, including polyhexamethylene guanidine phosphate (PHMG-P), which is also used as a biocide as it selectively disrupts bacterial cell membrane. It is used to clean humidifiers commonly used in the dry winter season in South Korea, which exposes people to PHMG-P ...
Jinsoo, Lee, Seong-Jin, Choi, Ji-Seong, Jeong, Sang Yun, Kim, Sang-Hyub, Lee, Mi Jin, Yang, Seung-Jin, Lee, Young-Jun, Shin, Kyuhong, Lee, Eun Ju, Jeong, Sang-Yoon, Nam, Wook-Joon, Yu   +11 more
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Oleanolic acid acetate attenuates polyhexamethylene guanidine phosphate-induced pulmonary inflammation and fibrosis in mice

Respiratory Physiology & Neurobiology, 2018
Oleanolic acid acetate (OAA), triterpenoid compound isolated from Vigna angularis (azuki bean), has been revealed anti-inflammatory in several studies. We investigated the effects of OAA against polyhexamethylene guanidine phosphate (PHMG-P)-induced pulmonary inflammation and fibrosis in mice.
Min-Seok, Kim, Jin-Young, Han, Sung-Hwan, Kim, Doin, Jeon, Hyeon-Young, Kim, Seung Woong, Lee, Mun-Chual, Rho, Kyuhong, Lee   +7 more
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Reproductive and developmental toxicity screening of polyhexamethylene guanidine phosphate by oral gavage in rats

Regulatory Toxicology and Pharmacology, 2019
Polyhexamethylene guanidine phosphate (PHMG-P) has effective antimicrobial activity against various microorganisms and has been widely used as a biocide in commercial products. However, its use as a humidifier disinfectant has provoked fatal idiopathic lung disease in South Korea, especially in pregnant or postpartum women and their young children ...
Jinsoo Lee, Ji-Seong Jeong, Sang Yun Kim, Wan-Jung Im, Young-Jun Shin, Kyuhong Lee, Seong-Jin Choi, Yongju Heo, Eun Ju Jeong, Sang-Yoon Nam, Wook-Joon Yu   +10 more
openaire   +4 more sources