Results 141 to 150 of about 609 (153)
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Regulatory Toxicology and Pharmacology, 2019
Polyhexamethylene guanidine phosphate (PHMG-P) has effective antimicrobial activity against various microorganisms and has been widely used as a biocide in commercial products. However, its use as a humidifier disinfectant has provoked fatal idiopathic lung disease in South Korea, especially in pregnant or postpartum women and their young children ...
Jinsoo Lee +10 more
openaire +2 more sources
Polyhexamethylene guanidine phosphate (PHMG-P) has effective antimicrobial activity against various microorganisms and has been widely used as a biocide in commercial products. However, its use as a humidifier disinfectant has provoked fatal idiopathic lung disease in South Korea, especially in pregnant or postpartum women and their young children ...
Jinsoo Lee +10 more
openaire +2 more sources
Inhalation Toxicology, 2019
Abstracts Objective: The major active ingredient of humidifier disinfectant, polyhexamethylene guanidine-phosphate (PHMG-P), caused hundreds of deaths with pulmonary fibrosis. However, structurally similar guanidine-based disinfectants are still in use in various fields.
Yong Joo Park +4 more
openaire +2 more sources
Abstracts Objective: The major active ingredient of humidifier disinfectant, polyhexamethylene guanidine-phosphate (PHMG-P), caused hundreds of deaths with pulmonary fibrosis. However, structurally similar guanidine-based disinfectants are still in use in various fields.
Yong Joo Park +4 more
openaire +2 more sources
Toxicology Letters, 2018
Polyhexamethylene guanidine phosphate (PHMG-phosphate), an active component of humidifier disinfectant, is suspected to be a major cause of pulmonary fibrosis. Fibrosis, induced by recurrent epithelial damage, is significantly affected by epigenetic regulation, including microRNAs (miRNAs).
Da Young, Shin +4 more
openaire +2 more sources
Polyhexamethylene guanidine phosphate (PHMG-phosphate), an active component of humidifier disinfectant, is suspected to be a major cause of pulmonary fibrosis. Fibrosis, induced by recurrent epithelial damage, is significantly affected by epigenetic regulation, including microRNAs (miRNAs).
Da Young, Shin +4 more
openaire +2 more sources
Toxicology and Industrial Health, 2017
Exposure to the humidifier disinfectant, polyhexamethylene guanidine phosphate (PHMG), in mists generated from ultrasonic humidifiers was studied in a simulation chamber and apartment rooms. PHMG is suspected as a causative agent of lung disease in Korea residences.
Ji Hyun, Lee, Il Je, Yu
openaire +2 more sources
Exposure to the humidifier disinfectant, polyhexamethylene guanidine phosphate (PHMG), in mists generated from ultrasonic humidifiers was studied in a simulation chamber and apartment rooms. PHMG is suspected as a causative agent of lung disease in Korea residences.
Ji Hyun, Lee, Il Je, Yu
openaire +2 more sources
Chemico-Biological Interactions, 2019
Epidemiological and toxicological studies indicate that polyhexamethylene guanidine phosphate (PHMG-p) is a guanidine-based cationic disinfectant strongly associated with interstitial lung diseases. As individuals exposed to aerosolized PHMG-p complain of respiratory problems (asthma and rhinitis), whether PHMG-p can cause respiratory diseases other ...
Mi Ho Jeong +3 more
openaire +2 more sources
Epidemiological and toxicological studies indicate that polyhexamethylene guanidine phosphate (PHMG-p) is a guanidine-based cationic disinfectant strongly associated with interstitial lung diseases. As individuals exposed to aerosolized PHMG-p complain of respiratory problems (asthma and rhinitis), whether PHMG-p can cause respiratory diseases other ...
Mi Ho Jeong +3 more
openaire +2 more sources
Toxicology
Pyroptosis is a form of programmed cell death characterized by gasdermin (GSDM)-mediated pore formation in the cell membrane, resulting in the release of pro-inflammatory cytokines and cellular lysis. Increasing evidence has shown that pyroptosis is responsible for the progression of various pulmonary disorders.
Jun Young, Park +5 more
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Pyroptosis is a form of programmed cell death characterized by gasdermin (GSDM)-mediated pore formation in the cell membrane, resulting in the release of pro-inflammatory cytokines and cellular lysis. Increasing evidence has shown that pyroptosis is responsible for the progression of various pulmonary disorders.
Jun Young, Park +5 more
openaire +2 more sources
Toxicology Letters, 2015
Polyhexamethylene guanidine (PHMG) phosphate is a competitive disinfectant with strong antibacterial activity. However, epidemiologists revealed that inhaled PHMG-phosphate may increase the risk of pulmonary fibrosis associated with inflammation, resulting in the deaths of many people, including infants and pregnant women.
Ha Ryong, Kim +2 more
openaire +2 more sources
Polyhexamethylene guanidine (PHMG) phosphate is a competitive disinfectant with strong antibacterial activity. However, epidemiologists revealed that inhaled PHMG-phosphate may increase the risk of pulmonary fibrosis associated with inflammation, resulting in the deaths of many people, including infants and pregnant women.
Ha Ryong, Kim +2 more
openaire +2 more sources
P20-10 A new murine liver fibrosis model induced by polyhexamethylene guanidine-phosphate
Toxicology Letters, 2022K.T. Nam +7 more
openaire +1 more source
Toxic responses to polyhexamethylene guanidine phosphate in cytoplasmic organelles
Toxicology Letters, 2017In Jae Bang +4 more
openaire +1 more source
Journal of Hazardous Materials
Polyhexamethylene guanidine-phosphate (PHMG-p) is a main compound used as a humidifier disinfectant, but the systemic health effects of PHMG-p still need to be explored. The circulatory and blood system is the organ that comes into contact with compounds absorbed into the body after inhalation exposure, resulting in various health problems, including ...
Sungbin Choi +6 more
openaire +2 more sources
Polyhexamethylene guanidine-phosphate (PHMG-p) is a main compound used as a humidifier disinfectant, but the systemic health effects of PHMG-p still need to be explored. The circulatory and blood system is the organ that comes into contact with compounds absorbed into the body after inhalation exposure, resulting in various health problems, including ...
Sungbin Choi +6 more
openaire +2 more sources