Results 81 to 90 of about 609 (153)

Chemical injury history increases pulmonary susceptibility to PM2.5 inhalation: Toxicological evidence for risk assessment in a neglected vulnerable population

Environment International
Environmental health risk assessments typically prioritize vulnerable populations such as the elderly, children, and individuals with respiratory diseases. However, individuals with a history of chemical-induced lung injury are rarely considered, despite
Dong Im Kim, Mi-Kyung Song, Jin-Seop Kim, Ji Eun Yuk, Jun Woo Kim, Jiwon Choi, Jiyoung Park, Kyuhong Lee   +7 more
doaj   +1 more source

Family-based case-control study of exposure to household humidifier disinfectants and risk of idiopathic interstitial pneumonia.

PLoS ONE, 2019
BackgroundIn Korea, several household humidifier disinfectants (HDs) were clinically confirmed to cause HD-associated lung injury (HDLI). Polyhexamethylene guanidine (PHMG) phosphate is the main ingredient of the HDs found to be associated with lung ...
Dirga Kumar Lamichhane, Jong-Han Leem, Sang-Min Lee, Hyeon-Jong Yang, Jaiyong Kim, Jong-Hyun Lee, Jung Keun Ko, Hwan Cheol Kim, Dong-Uk Park, Hae-Kwan Cheong   +9 more
doaj   +1 more source

Polyhexamethylene guanidine phosphate induces epithelial-to-mesenchymal transition and cancer stem cell-like properties via Wnt/β-catenin signaling in human bronchial epithelial cells

Ecotoxicology and Environmental Safety
Inhalation exposure to polyhexamethylene guanidine phosphate (PHMG-p), a primary component of humidifier disinfectants, has been linked to interstitial lung disease and potential carcinogenic effects.
Gi Ho Lee, Seung Yeon Lee, Yong-Wook Baek, Jungyun Lim, Kyu Hyuck Chung, Hye Gwang Jeong   +5 more
doaj   +1 more source

Method for Prioritizing Urban Pesticides for Monitoring [PDF]

Environmental Monitoring Branch (EM) is to monitor pesticide residues in surface waters with urban runoff inputs. Recent monitoring efforts have identified urban runoff as a major contributor of pesticides to California surface waters (Ensminger et al ...
Keith Starner, Michael Ensminger, Robert Budd, Surface Waters, Xin Deng, Yuzhou Luo   +5 more
core  

Role of exosome-derived miRNA-21-5p/Smad7 in quartz dust-induced pulmonary fibrosis in rats [PDF]

BackgroundQuartz dust cannot be degraded in the lungs, and inhalation of a large amount of quartz dust in the occupational production process will lead to the occurrence of pulmonary fibrosis, and then develop into silicosis.
Jiarui HAO, Jing SONG, Mengtong XU, Tiantian WANG, Wenjing LI, Xiaohui DING, Yang LU   +6 more
core   +1 more source

Polyhexamethylene guanidine phosphate-induced ROS-mediated DNA damage caused cell cycle arrest and apoptosis in lung epithelial cells

The Journal of Toxicological Sciences, 2019
Polyhexamethylene guanidine phosphate (PHMG-p) is an active ingredient of humidifier disinfectants and causes severe lung injury resulting in pulmonary fibrosis. Current evidence indicates that pulmonary fibrosis is initiated as a result of epithelial damage, which can lead to an inflammatory response and fibrotic cell infiltration; however, the toxic ...
Ji Soo, Park, Yong Joo, Park, Ha Ryong, Kim, Kyu Hyuck, Chung   +3 more
openaire   +3 more sources

Correlation between antibiotic and biocide resistance in mesophilic and psychrotrophic Pseudomonas spp. isolated from slaughterhouse surfaces throughout meat chain production [PDF]

, 2015
The aim of this study was to evaluate biocide susceptibility in mesophilic and psychrotrophic pseudomonads isolated from surfaces of a goat and lamb slaughterhouse, which was representative of the region.
Abriouel, Hikmate, Benomar, Nabil, Casado Munoz, María del Carmen, Gálvez, Antonio, Lavilla Lerma, Leyre   +4 more
core   +2 more sources

ANTIBACTERIAL ACTIVITY OF POLYHEXAMETHYLENE GUANIDINE PHOSPHATE DEPENDING ON ITS PRODUCTION TECHNOLOGY [PDF]

Современные проблемы науки и образования (Modern Problems of Science and Education), 2020
S.A. Lepekhova, V.K. Stankevich, E.V. Koval, G.E. Grigorev, P.O. Inozemtsev, L.E. Belozerov, A.P. Shelupaev   +6 more
openaire   +1 more source

Polyhexamethylene guanidine phosphate induces IL-6 and TNF-α expression through JNK-dependent pathway in human lung epithelial cells

The Journal of Toxicological Sciences, 2018
Polyhexamethylene guanidine phosphate (PHMG) is an antimicrobial biocide that causes severe lung injury accompanied with inflammation and subsequent fibrosis. Cytokines mediate the inflammatory response, leading to fibrosis in injured tissues. PHMG is known to induce the expression of various cytokines in vitro and in vivo.
Min-Seok, Kim, Jin-Young, Han, Sung-Hwan, Kim, Hyung-Young, Kim, Doin, Jeon, Kyuhong, Lee   +5 more
openaire   +3 more sources

Disruption of Membrane Integrity as a Molecular Initiating Event Determines the Toxicity of Polyhexamethylene Guanidine Phosphate Depending on the Routes of Exposure. [PDF]

Int J Mol Sci, 2022
Song J, Jung KJ, Yang MJ, Kim W, Lee BS, Choe SK, Kim SJ, Hwang JH.   +7 more
europepmc   +1 more source