Poly-saturated dolichols from filamentous fungi modulate activity of dolichol-dependent glycosyltransferase and physical properties of membranes [PDF]
Mono-saturated polyprenols (dolichols) have been found in almost all Eukaryotic cells, however, dolichols containing additional saturated bonds at the ω-end, have been identified in A. fumigatus and A. niger.
Bernat, Przemysław +14 more
core +2 more sources
Molecular Circuits of Resolution in Airway Inflammation
Inflammatory diseases of the lung are common, cause significant morbidity, and can be refractory to therapy. Airway responses to injury, noxious stimuli, or microbes lead to leukocyte recruitment for host defense. As leukocytes respond, they interact with lung resident cells and can elaborate specific mediators that are enzymatically generated from ...
Troy Carlo, Bruce D. Levy, Joan Clària
wiley +1 more source
A genome-wide MeSH-based literature mining system predicts implicit gene-to-gene relationships and networks [PDF]
Background The large amount of literature in the post-genomics era enables the study of gene interactions and networks using all available articles published for a specific organism.
He, Yongqun +3 more
core +1 more source
Lipoxins (LXs) represent a class of arachidonic acid (AA) metabolites that carry potent immunoregulatory and anti‐inflammatory properties, LXA4 and LXB4 being the main components of this series. LXs are generated by cooperation between 5‐lipoxygenase (LO) and 12‐ or 15‐LO during cell‐cell interactions or by single cell types.
Mario Romano +3 more
wiley +1 more source
Mycobacterium tuberculosis pks12 Produces a Novel Polyketide Presented by CD1c to T Cells [PDF]
CD1c-mediated T cells are activated by a mycobacterial phospholipid antigen whose carbohydrate structure precisely corresponds to mammalian mannosyl β-1-phosphodolichol (MPD), but contains an unusual lipid moiety.
Besra, Gurdyal S. +10 more
core +3 more sources
It is well appreciated that lipid‐derived mediators play key roles in inflammation and many other physiologic responses where multicellular processes are involved. Among them, lipoxins (LX) and aspirin‐triggered LX (ATL) evoke actions of interest in a range of physiologic and pathophysiologic processes, and these two series have emerged as founding ...
Charles N. Serhan, Nan Chiang
wiley +1 more source
From glycosylation disorders to dolichol biosynthesis defects: a new class of metabolic diseases [PDF]
Polyisoprenoid alcohols are membrane lipids that are present in every cell, conserved from archaea to higher eukaryotes. The most common form, alpha-saturated polyprenol or dolichol is present in all tissues and most organelle membranes of eukaryotic ...
A Acosta-Serrano +50 more
core +3 more sources
Structural elucidation of the cis -prenyltransferase NgBR/DHDDS complex reveals insights in regulation of protein glycosylation [PDF]
Cis- prenyltransferase ( cis- PTase) catalyzes the rate-limiting step in the synthesis of glycosyl carrier lipids required for protein glycosylation in the lumen of endoplasmic reticulum.
Edani, Ban H +7 more
core +1 more source
Quantitative assay and subcellular distribution of enzymes acting on dolichyl phosphate in rat liver [PDF]
To establish on a quantitative basis the subcellular distribution of the enzymes that glycosylate dolichyl phosphate in rat liver, preliminary kinetic studies on the transfer of mannose, glucose, and N-acetylglucosamine-1-phosphate from the respective ...
Amar-Costesec, A +3 more
core +2 more sources
The cis‐prenyltransferase protein family in Taraxacum koksaghyz
Significance Statement The novelty of this work lies in the comprehensive description of cis‐prenyl transferases in the rubber‐producing plant Taraxacum koksaghyz. This provides valuable insights for breeding and rational protein design in heterologous systems.
Boje Müller +6 more
wiley +1 more source

