Results 191 to 200 of about 31,758 (236)

Engineering a Plant Polyketide Synthase for the Biosynthesis of Methylated Flavonoids. [PDF]

J Agric Food Chem
Peng B, Zhang L, He S, Oerlemans R, Quax WJ, Groves MR, Haslinger K.   +6 more
europepmc   +1 more source

Extended polyene formation by a cryptic iterative polyketide synthase from Rhodococcus.

Chem Commun (Camb)
Prasongpholchai P, Tucker S, Burgess C, Jenkins R, Wilkening I, Corre C, Song L, Tosin M.   +7 more
europepmc   +1 more source

Modular polyketide synthase ketosynthases collaborate with upstream dehydratases to install double bonds.

Chem Commun (Camb)
Ray KA, Saif N, Keatinge-Clay AT.
europepmc   +1 more source

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Biosynthesis of polyketides by trans-AT polyketide synthases

Natural Product Reports, 2016
This review discusses the biosynthesis of natural products that are generated bytrans-AT polyketide synthases, a family of catalytically versatile enzymes that represents one of the major group of proteins involved in the production of bioactive polyketides.
Helfrich Eric J N, Piel Jörn
openaire   +2 more sources

Structure of a modular polyketide synthase [PDF]

Nature, 2014
Polyketide natural products constitute a broad class of compounds with diverse structural features and biological activities. Their biosynthetic machinery, represented by type I polyketide synthases (PKSs), has an architecture in which successive modules catalyse two-carbon linear extensions and keto-group processing reactions on intermediates ...
Somnath Dutta, Douglas A Hansen, Alison R H Narayan   +2 more
exaly   +3 more sources

Fungal type III polyketide synthases

Nat. Prod. Rep., 2014
This article covers the literature on fungal type III polyketide synthases (PKSs) published from 2005 to 2014. Since the first discovery of fungal type III PKS genes in Aspergillus oryzae, reported in 2005, putative genes for type III PKSs have been discovered in fungal genomes.
Makoto, Hashimoto, Takamasa, Nonaka, Isao, Fujii   +2 more
openaire   +2 more sources

Engineering of modular polyketide synthases to produce novel polyketides

Current Opinion in Biotechnology, 1998
Polyketides are important natural products produced by Actinomycetes and other organisms via the polymerization of coenzyme A-activated carboxylic acids. Modular polyketide synthases are large multifunctional enzymes that direct the biosynthetic process using a dedicated 'module' for each polymerization reaction, which specifies the unit to be ...
, Carreras, , Santi
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Biphenyl synthase, a novel type III polyketide synthase

Planta, 2006
Biphenyls and dibenzofurans are the phytoalexins of the Maloideae, a subfamily of the economically important Rosaceae. The carbon skeleton of the two classes of antimicrobial secondary metabolites is formed by biphenyl synthase (BIS). A cDNA encoding this key enzyme was cloned from yeast-extract-treated cell cultures of Sorbus aucuparia. BIS is a novel
B, Liu, T, Raeth, T, Beuerle, L, Beerhues   +3 more
openaire   +2 more sources

Biosynthesis of polyketides by trans-AT polyketide synthases

Natural Product Reports, 2010
This review discusses the biosynthesis of natural products that are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes that have recently been recognized as one of the major group of proteins involved in the production of bioactive polyketides. 436 references are cited.
openaire   +2 more sources

Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases

Nature, 1995
Modular polyketide synthases (PKSs) are complex multi-enzyme proteins that catalyse the bacterial biosynthesis of many pharmaceutically useful polyketides. The PKSs are organized into a series of modules, each containing the active catalytic sites required for one step in the synthesis process.
R, Pieper, G, Luo, D E, Cane, C, Khosla
openaire   +2 more sources