Results 201 to 210 of about 31,758 (236)
Some of the next articles are maybe not open access.
Tolerance and Specificity of Polyketide Synthases
Annual Review of Biochemistry, 1999▪ Abstract Polyketide synthases catalyze the assembly of complex natural products from simple precursors such as propionyl-CoA and methylmalonyl-CoA in a biosynthetic process that closely parallels fatty acid biosynthesis. Like fatty acids, polyketides are assembled by successive decarboxylative condensations of simple precursors.
C, Khosla +3 more
openaire +2 more sources
Non-modular polyketide synthases in myxobacteria
Phytochemistry, 2009Myxobacteria are prolific producers of a wide variety of secondary metabolites. The vast majority of these compounds are complex polyketides which are biosynthesised by multimodular polyketide synthases (PKSs). In contrast, few myxobacterial metabolites isolated to date are derived from non-modular PKSs, in particular type III PKSs. This review reports
Yanyan, Li, Rolf, Müller
openaire +2 more sources
Polyketide Synthase Genes from Marine Dinoflagellates
Marine Biotechnology, 2003Rapidly developing techniques for manipulating the pathways of polyketide biosynthesis at the genomic level have created the demand for new pathways with novel biosynthetic capability. Polyketides derived from dinoflagellates are among the most complex and unique structures identified thus far, yet no studies of the biosynthesis of dinoflagellate ...
Snyder, R. V. +6 more
openaire +3 more sources
Polyketide Synthases: Mechanisms and Models
2006The modular structure of the multienzyme PKSs makes them particularly attractive targets for combinatorial biosynthesis aimed at generating novel polyketide medicines. We are beginning to understand those features of subunit organization and structure and their linking and docking elements, which are critical for productive engineering efforts ...
openaire +2 more sources
Building-block selectivity of polyketide synthases
Current Opinion in Chemical Biology, 2003For the past decade, polyketide synthases have presented an exciting paradigm for the controlled manipulation of complex natural product structure. These multifunctional enzymes catalyze the biosynthesis of polyketide natural products by stepwise condensation and modification of metabolically derived building blocks.
Grace F, Liou, Chaitan, Khosla
openaire +2 more sources
Polyketide Synthase Secrets Revealed
Chemical & Engineering News Archive, 2014A new study solves long-standing mysteries about how bacterial natural-product-making factories are put together and how they work. The findings could accelerate efforts to engineer these workshops to produce novel bioactive agents for drug discovery. Bacteria use huge multienzyme complexes called polyketide synthases (PKSs) to create a wide variety of
openaire +1 more source
Structures and Mechanisms of Polyketide Synthases
The Journal of Organic Chemistry, 2009Nearly a quarter-century ago, the advent of molecular genetic tools in the field of natural product biosynthesis led to the remarkable revelation that the genes responsible for the biosynthesis, regulation, and self-resistance of complex polyketide antibiotics were clustered in the genomes of the bacteria that produced these compounds.
openaire +2 more sources
Novel applications of plant polyketide synthases
Current Opinion in Chemical Biology, 2012The structurally and mechanistically simple type III polyketide synthases (PKSs) catalyze iterative condensations of CoA thioesters to produce a variety of polyketide scaffolds with remarkably diverse structures and biological activities. By exploiting the enzymes, we combined precursor-directed biosynthesis with nitrogen-containing substrates and ...
openaire +2 more sources
The Chalcone Synthase Superfamily of Type III Polyketide Synthases
ChemInform, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
Michael B, Austin, Joseph P, Noel
openaire +2 more sources
Chalcone synthases (CHSs): the symbolic type III polyketide synthases
Planta, 2019Present review provides a thorough insight on some significant aspects of CHSs over a period of about past three decades with a better outlook for future studies toward comprehending the structural and mechanistic intricacy of this symbolic enzyme. Polyketide synthases (PKSs) form a large family of iteratively acting multifunctional proteins that are ...
Shahzad A, Pandith +4 more
openaire +2 more sources