Results 21 to 30 of about 15,660 (211)
Iterative polyketide biosynthesis by modular polyketide synthases in bacteria [PDF]
Applied Microbiology and Biotechnology, 2015 Modular polyketide synthases (type I PKSs) in bacteria are responsible for synthesizing a significant percentage of bioactive natural products. This group of synthases has a characteristic modular organization, and each module within a PKS carries out one cycle of polyketide chain elongation; thus each module is non-iterative in function.
Haotong, Chen, Liangcheng, Du
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Nature Communications, 2021 Trans-acyltransferase polyketide synthases are multimodular enzymes that synthesise diverse polyketides. Here, the authors present an algorithm for the global study of their diversity, showing exchange of conserved consecutive modules as a driver of ...
Eric J. N. Helfrich +10 more
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Biocatalytic Synthesis of Stereospecific Triketide Lactones using Polyketide Synthases [PDF]
, 2016 Polyketide synthases are modular enzymes that create and modify large acyl chains. The domains and modules of polyketide synthases allow us to create molecules that resemble naturally occurring products by applying a biocatalytic in vitro in vivo ...
Alexander, Bradley
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Cleaning up Polyketide Synthases
Chemistry & Biology, 2012 Complex biosynthetic enzymes such as polyketide synthases make mistakes. In this issue of Chemistry & Biology, Jensen et al. report that a discrete family of acyltransferases is responsible for error correction, hydrolyzing key biosynthetic intermediates from a multi-enzyme complex. This activity might find use in understanding polyketide biosynthesis,
Kwan, Jason C., Schmidt, Eric W.
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Chemoinformatic-guided engineering of polyketide synthases [PDF]
Journal of the American Chemical Society, 2019 AbstractPolyketide synthase (PKS) engineering is an attractive method to generate new molecules such as commodity, fine and specialty chemicals. A significant challenge in PKS design is engineering a partially reductive module to produce a saturated β-carbon through a reductive loop exchange.
Amin Zargar +25 more
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Molecular Plant-Microbe Interactions, 2001 Many biocontrol fluorescent pseudomonads can protect plants from soilborne fungal pathogens through production of the antifungal secondary metabolite 2,4-diacetylphloroglucinol (Phl). One of the phl biosynthetic genes, phlD, encodes a polyketide synthase
Alban Ramette +2 more
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Aspergillus westerdijkiae polyketide synthase gene “aoks1” is involved in the biosynthesis of ochratoxin A [PDF]
, 2009 OchratoxinA (OTA) is a potential nephrotoxic, teratogenic, immunogenic, hepatotoxic and carcinogenic mycotoxin, produced by Aspergillus westerdijkiae NRRL 3174.
Atoui, Ali +4 more
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Polyketide Synthase Modules Redefined [PDF]
Angewandte Chemie International Edition, 2017 Modular redefinition: A long-standing paradigm in modular polyketide synthase enzymology, namely the definition of a module, has been challenged by Abe and co-workers in their recent study. With this new understanding has emerged renewed hope for engineering these assembly lines to produce new materials and medicines.
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Don't Classify Polyketide Synthases [PDF]
Chemistry & Biology, 2004 Polyketide synthases are intensively studied as metabolite factories generating diverse biologically active natural products. Contrary to their current classification as different "types," there is now a growing body of evidence illustrating that nature realized limitless transitional stages during evolution.
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Manipulating polyketide stereochemistry by exchange of polyketide synthase modules
Chemical Communications, 2020 Exchange of polyketide synthase (PKS) modules by genetic engineering leads to efficient modification of polyketide stereochemistry.
Massicard, Jean-Malo +3 more
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