Results 61 to 70 of about 15,660 (211)

The Transcription Factor FgSge1 Harnesses the SAGA Complex to Activate Mycotoxin Biosynthesis and Fungal Virulence

Advanced Science, EarlyView.
This study reveals the molecular mechanism by which the transcription factor FgSge1 regulates mycotoxin biosynthesis and virulence in Fusarium graminearum. FgSge1 binds to the TAARGTTT cis‐element, enabling self‐activation. It recruits the SAGA complex, promotes histone acetylation, and facilitates jet‐like chromatin remodeling, thereby activating ...
Yueqi Zhang, Jingrui Wang, Qiaowan Chen, Chen Jiao, Yun Chen, Zhongshou Wu, Zhonghua Ma   +6 more
wiley   +1 more source

Short-chain ketone production by engineered polyketide synthases in Streptomyces albus

Nature Communications, 2018
Mutating natural enzymes is effective in broadening the substrate or product range, but generally leads to reduced titers. Here the authors engineer hybrid polyketide synthases for efficient production of short-chain ketones from plant biomass ...
Satoshi Yuzawa, Mona Mirsiaghi, Renee Jocic, Tatsuya Fujii, Fabrice Masson, Veronica T. Benites, Edward E. K. Baidoo, Eric Sundstrom, Deepti Tanjore, Todd R. Pray, Anthe George, Ryan W. Davis, John M. Gladden, Blake A. Simmons, Leonard Katz, Jay D. Keasling   +15 more
doaj   +1 more source

Mechanism of subunit interaction at ketosynthase-dehydratase junctions in trans-AT polyketide synthases [PDF]

, 2018
Modular polyketide synthases (PKSs) produce numerous structurally complex natural products with diverse applications in medicine and agriculture. They typically consist of several multienzyme subunits that utilize structurally-defined docking domains ...
A Keatinge-Clay, AG Palmer III., Andrew S Barrow, AS Worthington, AS Worthington, AT Keatinge-Clay, AT Keatinge-Clay, BG Pierce, C Hertweck, CD Richter, Daniel Griffiths, DT Wagner, DT Wagner, E Lescop, EJN Helfrich, FH Schumann, GM Pavlović-Lažetić, Gregory L Challis, J Bellay, J Dorival, J Kuo, J Nilsson, J Yang, J Zeng, JG Lees, JL Meier, John E Moses, Józef R Lewandowski, KJ Weissman, L Gitlin, L Katz, L Manzi, L Song, L Whitmore, LJ McGuffin, Lucio Manzi, MA Fischbach, MA Larkin, Matthew Jenner, MP Williamson, MR Jensen, Neil J Oldham, Panward Prasongpholchai, PE Wright, RS Gokhale, RW Broadhurst, S Kapur, S Kosol, S Vucetic, Simone Kosol, SR Eddy, TJ Buchholz, V Neduva, VB Chen, VN Uversky, WF Vranken, YS Lin, Z Dosztányi, Z Dosztányi   +58 more
core   +3 more sources

Systematic Engineering of Proteases in Saccharopolyspora Spinosa Reveals Synergistic Enhancement of Spinosad Biosynthesis via Substrate Flux Optimization

Advanced Science, EarlyView.
ARTP mutagenesis yielded Saccharopolyspora spinosa mutant D184 with improved extracellular nitrogen utilization. An integrated workflow of protease genetic manipulation, multi‐omics, and rational synergy design pinpointed a pepP‐clpP‐htpX synergistic triangular combination.
Duo Jin, Wangqiong Chen, Danlu Yang, Qing Liu, Baolong Bai, Zirui Dai, Xirong Liu, Zirong Zhu, Jie Rang, Liqiu Xia   +9 more
wiley   +1 more source

Acyltransferases as Tools for Polyketide Synthase Engineering

Antibiotics, 2018
Polyketides belong to the most valuable natural products, including diverse bioactive compounds, such as antibiotics, anticancer drugs, antifungal agents, immunosuppressants and others.
Ewa Maria Musiol-Kroll, Wolfgang Wohlleben   +1 more
doaj   +1 more source

Identification of candidate genes affecting Delta9-tetrahydrocannabinol biosynthesis in Cannabis sativa. [PDF]

, 2009
RNA isolated from the glands of a Delta(9)-tetrahydrocannabinolic acid (THCA)-producing strain of Cannabis sativa was used to generate a cDNA library containing over 100 000 expressed sequence tags (ESTs).
Dixon, Richard A, Gang, David R, He, Ji, Marks, M David, Omburo, Stephanie N, Soto-Fuentes, Wilfredo, Tian, Li, Weiblen, George D, Wenger, Jonathan P   +8 more
core  

A Genomic Catalog of Migratory Microbiomes from Wild Birds across China's Habitats

Advanced Science, EarlyView.
ABSTRACT Migratory birds play an important role in the spread of antimicrobial resistance (AMR); however, gaps in surveillance data from vital regions along migratory flyways across China limit the detection of emergent threats. Here, we assembled 340 metagenomes from 52 bird species covering 11 provincial administrative districts in China, presenting ...
Yanan Wang, Heqi Wu, Mengqi Qu, Chunge Zhang, Ziqian Xu, Yuhang Pei, Chaochao Zhao, Jiangtao Wang, Sufang Ma, Na Lyu, Xuebin Xu, Yuhai Bi, Baoli Zhu, George F. Gao   +13 more
wiley   +1 more source

Evolution of polyketide synthases in bacteria [PDF]

Proceedings of the National Academy of Sciences, 2008
The emergence of resistant strains of human pathogens to current antibiotics, along with the demonstrated ability of polyketides as antimicrobial agents, provides strong motivation for understanding how polyketide antibiotics have evolved and diversified in nature.
Christian P, Ridley, Ho Young, Lee, Chaitan, Khosla   +2 more
openaire   +2 more sources

De novo genome assembly and annotation of rice sheath rot fungus Sarocladium oryzae reveals genes involved in Helvolic acid and Cerulenin biosynthesis pathways [PDF]

, 2016
Morphology of Saro-13 isolate used for whole genome sequencing.
Channappa Mahadevaiah, H. B. Mahesh, Mothukapalli Krishnareddy Prasannakumar, Shailaja Hittalmani   +3 more
core   +9 more sources

Biosynthesis of aromatic polyketides in microorganisms using type II polyketide synthases [PDF]

Microbial Cell Factories, 2020
AbstractAromatic polyketides have attractive biological activities and pharmacological properties. Different from other polyketides, aromatic polyketides are characterized by their polycyclic aromatic structure. The biosynthesis of aromatic polyketides is usually accomplished by the type II polyketide synthases (PKSs), which produce highly diverse ...
Jia Wang, Ruihua Zhang, Xin Chen, Xinxiao Sun, Yajun Yan, Xiaolin Shen, Qipeng Yuan   +6 more
openaire   +3 more sources