Results 101 to 110 of about 19,197 (232)

Tanzawaic acids I–L: Four new polyketides from Penicillium sp. IBWF104-06

Beilstein Journal of Organic Chemistry, 2014
Four new polyketides have been identified in culture filtrates of the fungal strain Penicillium sp. IBWF104-06 isolated from a soil sample. They are structurally based on the same trans-decalinpentanoic acid skeleton as tanzawaic acids A–H.
Louis P. Sandjo, Eckhard Thines, Till Opatz, Anja Schüffler   +3 more
doaj   +1 more source

Methyl Jasmonate Seed Priming Mitigates the Defence‐Growth Trade‐Off and Tailors Plant Response to Specific Pests

Plant, Cell &Environment, EarlyView.
ABSTRACT Seed defence priming is emerging as a novel, cost‐efficient and environmentally safe tool for pest management. It has been proposed as a means to uncouple the defence‐growth trade‐off in plants by enhancing defence responses with minimal fitness costs, but the mechanisms underlying this role remain elusive.
Lucia Talavera‐Mateo, Adrian Sabater‐Gabriel, Alejandro Garcia, Marta Marina Perez‐Alonso, Rayko Halitschke, M. Estrella Santamaria   +5 more
wiley   +1 more source

From DNA Sequences to Chemical Structures – Methods for Mining Microbial Genomic and Metagenomic Data Sets for New Natural Products

Food Technology and Biotechnology, 2010
Rapid mining of large genomic and metagenomic data sets for modular polyketide synthases, non-ribosomal peptide synthetases and hybrid polyketide synthase/non-ribosomal peptide synthetase biosynthetic gene clusters has been achieved using the generic ...
Jurica Zucko, Antonio Starcevic, Janko Diminic, Mouhsine Elbekali, Mohamed Lisfi, Paul F. Long, John Cullum, Daslav Hranueli   +7 more
doaj  

Deciphering Role of Endophytes in Plant Defences and Biotic Stress Resilience Across Families

Plant, Cell &Environment, EarlyView.
ABSTRACT Plant families generate distinct repertoires of specialised metabolites that govern their biotic interactions. Endophytes strengthen host plant defence mechanisms and tolerance to biotic challenges by upregulating metabolite biosynthesis, modifying precursor compounds into more potent forms, or by directly synthesising analogous defence ...
S. Aneeqa Noor, Kavita Verma, Nishu, Barkat Hussain, Vartika Mathur   +4 more
wiley   +1 more source

Advances in large DNA fragment assembly for microbial cell factory engineering

Quantitative Biology, Volume 14, Issue 3, September 2026.
Abstract The efficient, rapid, and reliable assembly of DNA fragments is essential for advancing metabolic engineering and synthetic biology. With the rapid advancement of DNA synthesis and assembly technologies, the scale of DNA assembly has expanded from single genes to metabolic pathways and even genomes.
Yu Zhang, Wenqian Liu, Dongyuan Cheng, Jiazhang Lian, Xian Fu, Yue Shen   +5 more
wiley   +1 more source

Enhancing IR‐MALDESI MSI Spatial Resolution Through Beam Constriction With a Ring‐Actuated Iris

Rapid Communications in Mass Spectrometry, Volume 40, Issue 16, 30 August 2026.
ABSTRACT Rationale Infrared matrix‐assisted laser desorption electrospray ionization (IR‐MALDESI) mass spectrometry imaging (MSI) enables label‐free, spatially resolved molecular analysis of biological tissues under ambient conditions. While improving spatial resolution is important for mapping fine tissue structures, mid‐infrared (IR) lasers are ...
Sarah M. Ashbacher, Seth M. Eisenberg, Alexander A. C. Wainwright, Aosheng Gu, Syeda N. Mahdia, R. J. Dwayne Miller, David C. Muddiman   +6 more
wiley   +1 more source

Cracking the Polyketide Code

PLoS Biology, 2004
Polyketides, natural products from microorganisms, have been a main source of antibiotics. Understanding the 'programming' of the enzymes that produce these complex molecules has opened a new field of drug ...
openaire   +4 more sources

Barley HvBODYGUARD1 controls cuticular specialisations regulated by SHINE transcription factors

New Phytologist, Volume 251, Issue 3, Page 1188-1208, August 2026.
Cuticle defects result from defective HvBDG1 alleles. Summary Land plants secrete a protective outer cuticular layer with diverse functions. Barley (Hordeum vulgare L.) develops two cuticular specialisations: the β‐diketone rich wax bloom on vegetative tissues and an adherent grain surface which sticks to the hulls, leading to barley's distinctive ...
Trisha McAllister, Chiara Campoli, Linsan Liu, Tansy Chia, S. Ronan Fisher, Richard Horsnell, Alan R. Prescott, Jennifer Shoesmith, Mhmoud Eskan, Alasdair Iredale, Mirjam Nuter, Luke Ramsay, Micha M. Bayer, Linda Milne, Miriam Schreiber, Yogeswari Rajarathinam, Vanessa Wahl, Robbie Waugh, James Cockram, Sarah M. McKim   +19 more
wiley   +1 more source

Polyketide Derivatives from the Mangrove-Derived Fungus Penicillium sp. HDN15-312

Marine Drugs
Four new polyketides, namely furantides A–B (1–2), talamin E (3) and arugosinacid A (4), and two known polyketides were obtained from the mangrove-derived fungus Penicillium sp. HDN15-312 using the One Strain Many Compounds (OSMAC) strategy.
Fuhao Liu, Wenxue Wang, Feifei Wang, Luning Zhou, Guangyuan Luo, Guojian Zhang, Tianjiao Zhu, Qian Che, Dehai Li   +8 more
doaj   +1 more source

Mutasynthesis and Antibiotic Activity of Mupirocin Analogues

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
A mutasynthetic strategy was developed to prepare pseudomonic acid analogues, and their antimicrobial activities were evaluated against five bacterial strains. Feeding studies with mutant strains of Pseudomonas fluorescens revealed that C7‐desepoxy‐PA‐B was metabolised to C7‐PA‐C with loss of the 8‐hydroxyl group, but no fatty acid chain extension ...
Sarah M. Husain, Luoyi Wang, Li‐Chen Han, James I. Bowen, Zhongshu Song, Felix de Courcy‐Ireland, Ashley J. Winter, Thomas J. Simpson, Paul R. Race, James Spencer, Matthew P. Crump, Christine L. Willis   +11 more
wiley   +1 more source