Results 101 to 110 of about 15,852 (221)

Systematic prioritization of candidate genes in camptothecin biosynthesis using multi‐omics and deep learning

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract Camptothecin (CPT), a plant‐derived monoterpene indole alkaloid first identified in Camptotheca acuminata, is a drug precursor widely used for cancer chemotherapeutics. However, the full set of genes responsible for CPT biosynthesis remains unclear, hindering efforts to elucidate the complete pathway or establish biosynthetic production of CPT
Shenqi Wang, Xing Wu, Maria Moreno, Joonseok Oh, Stephen L. Dellaporta, Jason M. Crawford, Farren J. Isaacs   +6 more
wiley   +1 more source

Enhancing IR‐MALDESI MSI Spatial Resolution Through Beam Constriction With a Ring‐Actuated Iris

Rapid Communications in Mass Spectrometry, Volume 40, Issue 16, 30 August 2026.
ABSTRACT Rationale Infrared matrix‐assisted laser desorption electrospray ionization (IR‐MALDESI) mass spectrometry imaging (MSI) enables label‐free, spatially resolved molecular analysis of biological tissues under ambient conditions. While improving spatial resolution is important for mapping fine tissue structures, mid‐infrared (IR) lasers are ...
Sarah M. Ashbacher, Seth M. Eisenberg, Alexander A. C. Wainwright, Aosheng Gu, Syeda N. Mahdia, R. J. Dwayne Miller, David C. Muddiman   +6 more
wiley   +1 more source

ω‐Hydroxyacid Dehydrogenases From Clostridium viride: Iron‐Containing Biocatalysts With Biotechnological Potential

ChemBioChem, Volume 27, Issue 16, 27 August 2026.
ω‐Hydroxy and ω‐oxo acids are precursors to lactones, polyesters, and nylon‐6, yet selective interconverting enzymes remain scarce. Clostridium viride supplies two iron alcohol dehydrogenases: Cvir‐Hbd2, restricted to C4, and the genomic singleton Cvir‐Hvd, spanning C5–C12 substrates.
Tarik Begic, Julia Hill, Jan L. Stitzel, Lukas Knauer, Volker Schünemann, Markus Räschle, Berta M. Martins, Antonio J. Pierik   +7 more
wiley   +1 more source

Fragmentation of Vancoresmycin Reveals a Strong Dependence on Global Molecular Architecture for Antibacterial Activity

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Fragmentation of the natural product vancoresmycin reveals an essential role of global architecture for biological potency. Vancoresmycin is a structurally complex tetramic‐acid‐containing natural product with potent activity against Gram‐positive bacteria, yet its structure–activity relationships remain poorly defined.
Max Schönenbroicher, Florian Heppner, Maximilian Seul, Simon Morgenschweis, Aia Ali Abdelrahman, Eva Fahr, Niklas Holstein, Anna Müller, Dirk Menche   +8 more
wiley   +1 more source

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, Volume 13, Issue 46, 17 August 2026.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source

Discovery of VEGFR‐2 Inhibitors From Leonurus japonicus via Integrated Genetic Authentication, Molecular Networking, and In Silico Analysis

Archiv der Pharmazie, Volume 359, Issue 8, August 2026.
Genetic authentication of Leonurus japonicus was confirmed using ITS sequencing. UHPLC‐MS/MS‐GNPS analysis and isolation led to a new labdane diterpenoid (1) and known compounds (2–6), with anti‐angiogenic activity validated by EPC assays and VEGFR‐2 docking studies.
Thiyagarajan Raviraj, Chen‐Lin Yu, Aekkhaluck Intharuksa, Shang‐Chih Lai, Vidya Febrasca Tenderly, Yen Chi Loo, Pin‐Wei Chen, Shih‐Wei Wang, Kartiko Arif Purnomo, Soundar Rajan Kulandhaivel, Sedin Renadi, Stephen Lirio, Yuan‐Bin Cheng, Yu‐Liang Yang, Tsong‐Long Hwang, Fang‐Rong Chang, Michal Korinek   +16 more
wiley   +1 more source

Exploring the Roles of Tuna‐Associated Acinetobacter sp. YFT067: Implications for Host Health and Metabolism

Animal Research and One Health, Volume 4, Issue 3, Page 278-292, August 2026.
This study firstly isolated a tuna‐derived gut probiotic Acinetobacter seifertii YFT067. Dietary administration of YFT067 played significant roles in promoting growth performance, SCFAs production, lipid absorption, and metabolism of the host, indicating YFT067 as a promising probiotic candidate for enhancing tuna aquaculture productivity through ...
Ying Zou, Hai Huang, Qiongyao Fu, Zhiyuan Lu, Zhiqiang Guo   +4 more
wiley   +1 more source

Integrative Network Pharmacology and Transcriptomics Reveal the Mechanism of XuanShi Choudong Recipe in the Treatment of Tic Disorder

Brain and Behavior, Volume 16, Issue 8, August 2026.
Using an integrated strategy of network pharmacology and transcriptomics, this study elucidates the therapeutic mechanism of XuanShi Choudong Recipe (CDR) against tic disorder (TD). CDR dose‐dependently alleviates apomorphine‐induced tic‐like stereotypy and hyperlocomotion in rats, restores striatal neurotransmitter homeostasis, and attenuates ...
Hu Jue, Ma Jingying, Chen Yaqin, Pan Yulu, Chen Yanhong, Xu Jiaye, Chen Danfei, Chen Jian, Xuan Xiao‐bo   +8 more
wiley   +1 more source

Natural Photosensitizers in Cancer Therapy: A Chemo‐Biodiversity Perspective on Light‐Activated Natural Compounds

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
Natural photosensitizers, shaped by chemo‐biodiversity and evolution, offer diverse photoactive scaffolds for PDT. This review highlights their structure–activity relationships, photophysical properties, and nanotechnology‐based strategies to enhance efficacy, while addressing translational challenges and demonstrating how nature's molecular diversity ...
Isaac Baidoo, Heidi Abrahamse, Blassan P. George   +2 more
wiley   +1 more source

Unlocking Stereodefined Olefins by Z‐Selective Transition Metals‐catalyzed C−H Activations

ChemCatChem, Volume 18, Issue 15, 14 August 2026.
The synthesis of Z‐olefins is an important challenge in synthetic organic chemistry. Within this review, we report a comprehensive overview of transition metals‐catalyzed Z‐selective C–H activations of (hetero)arenes for the synthesis of stereodefined olefins.
Francesco Capranica, Silvia Cattani, Gianpiero Cera   +2 more
wiley   +1 more source