Results 71 to 80 of about 20,629 (261)
mBio, 2020 Marine sponges have been a prolific source of unique bioactive compounds that are presumed to act as a deterrent to predation. Many of these compounds have potential therapeutic applications; however, the lack of efficient and sustainable synthetic ...
Mathew A. Storey +7 more
doaj +1 more source
Polyketide stereotetrads in natural products [PDF]
Chemical Society Reviews, 2005 AbstractFor Abstract see ChemInform Abstract in Full Text.
Koskinen, Ari M.P., Karisalmi, Kaisa
openaire +3 more sources
An Oxetane-Based Polyketide Surrogate To Probe Substrate Binding in a Polyketide Synthase [PDF]
Journal of the American Chemical Society, 2018 Polyketides are a large class of bioactive natural products with a wide range of structures and functions. Polyketides are biosynthesized by large, multidomain enzyme complexes termed polyketide synthases (PKSs). One of the primary challenges when studying PKSs is the high reactivity of their poly-β-ketone substrates.
Bryan D. Ellis +10 more
openaire +5 more sources
Herbicidal Polyketides and Diketopiperazine Derivatives from Penicillium viridicatum
, 2019 Herbicidal activity-guided isolation from the fermentation extract of Penicillium viridicatum had obtained two herbicidal series of polyketides (1–7) and diketopiperazine derivatives (8–11), especially including three novel polyketides (1–3).
Yuan-Ming Zhou +9 more
core +1 more source
Engineering Polyketide Synthases [PDF]
The Scientific World JOURNAL, 2002 Complex polyketides, exemplified by the molecules shown in Fig. 1, are produced mainly from a group of mycelia-forming bacteria belonging to the actinomycete family and have applications in medicine or agriculture. Worldwide sales of polyketides exceed $15 B annually.
openaire +3 more sources
Catalyst‐Controlled Transannular Polyketide Cyclization Cascades: Selective Folding of Macrocyclic Polyketides [PDF]
, 2020 The biomimetic synthesis of aromatic polyketides from macrocyclic substrates by means of catalyst-controlled transannular cyclization cascades is described.
Vincent C. Fäseke +7 more
core +1 more source
Stalk cell differentiation without polyketides in the cellular slime mold
, 2016 Polyketides induce prestalk cell differentiation in Dictyostelium. In the double-knockout mutant of the SteelyA and B polyketide synthases, most of the pstA cells—the major part of the prestalk cells—are lost, and we show by whole mount in situ ...
Yukie G. Sato (2571154) +2 more
core +1 more source
Polyketides as Secondary Metabolites from the Genus Aspergillus
, 2023 Polyketides are an important class of structurally diverse natural products derived from a precursor molecule consisting of a chain of alternating ketone and methylene groups.
Xuelian Bai +8 more
core +1 more source
A Unified Approach for the Synthesis of Conformationally Locked and sp2‐sp3 Fused Hybrids
Chemistry – A European Journal, EarlyView.This study presents a systematic platform to build rigid sp2–sp3 hybrids via benzyne cycloadditions. Arene‑fused bicyclic oxa‐, aza‐, and carbocycles are converted into medicinally relevant amino acids and applied to Enalapril analogues synthesis. The hybrids combine aromatic interactions with 3D rigidity, tuning lipophilicity, pKa, and solubility ...
Ervis Saraci +8 more
wiley +1 more source
Isokibdelones: Novel Heterocyclic Polyketides from a Kibdelosporangium sp.
, 2016 The isokibdelones are an unprecedented family of polyketides produced by an Australian isolate of a rare actinomycete, Kibdelosporangium sp. The structures of the isokibdelones were assigned by spectroscopic analysis and chemical interconversion.
Jennifer H. Gill (2520592) +4 more
core +1 more source