Evaluation of the Synthesis and Skin Penetration Pathway of Folate-Conjugated Polymeric Micelles for the Dermal Delivery of Irinotecan and Alpha-Mangostin [PDF]
PharmaceuticsBackground/Objectives: The present study aimed to synthesize folate-conjugated poloxamers and develop polymeric micelles for the dermal delivery of irinotecan and alpha-mangostin for the treatment of melanoma using poloxamer 188 and poloxamer 184, which ...
Thanchanok Sirirak, Thirapit Subongkot
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New generation of electrochemical immunoassay based on polymeric nanoparticles for early detection of breast cancer [PDF]
International Journal of Nanomedicine, 2017 Fouzi Mouffouk,1 Sihem Aouabdi,2 Entesar Al-Hetlani,1 Hacene Serrai,3 Tareq Alrefae,4 Liaohai Leo Chen5 1Department of Chemistry, Kuwait University, Safat, Kuwait; 2King Abdullah International Medical Research Center (KAIMRC), Jeddah, Kingdom of Saudi ...
Mouffouk F +5 more
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Comparative Stability of Synthetic and Natural Polymeric Micelles in Physiological Environments: Implications for Drug Delivery [PDF]
PharmaceuticsPolymeric micelles are widely studied as nanocarriers for hydrophobic drugs, yet their structural stability under physiological conditions remains a major limitation.
Hurriyet Polat +4 more
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Gellan Gum-Based In Situ Hydrogels for Nasal Delivery of Polymeric Micelles Loaded with Risperidone [PDF]
GelsNasal drug delivery faces numerous challenges related to the ineffectiveness of most nasal formulations without a mucoadhesive nature, prolonging residence time on the nasal mucosa. Another challenge is the low administrable dosage strength, which can be
Bence Sipos +3 more
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Polymeric Micelles: Morphology, Synthesis, and Pharmaceutical Application [PDF]
E3S Web of Conferences, 2021 Polymeric micelles (PMs) are nanosized core-shell molecules formed by the self-assembly of amphiphilic block copolymers. Their unique morphologies, biocompatibility have allowed them to serve as drug carriers and have found wide applications in the ...
Bai Kun, Wang Anda
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Polymeric Micelles in Cancer Immunotherapy [PDF]
Molecules, 2021 Cancer immunotherapies have generated some miracles in the clinic by orchestrating our immune system to combat cancer cells. However, the safety and efficacy concerns of the systemic delivery of these immunostimulatory agents has limited their application.
Zhuoya Wan +7 more
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Biomaterials Research, 2022 Background Superparamagnetic iron oxide nanoparticles (SPIO) have been applied for decades to design theranostic polymeric micelles for targeted cancer therapy and diagnostic MR imaging. However, the effects of SPIO on the physicochemical, and biological
Yixin Jiang +5 more
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Intracellular K+-Responsive Block Copolymer Micelles for Targeted Drug Delivery of Curcumin
Frontiers in Bioengineering and Biotechnology, 2022 Curcumin (CUR) is a natural bioactive compound that has attracted attention as a “golden molecule” due to its therapeutic properties against several types of tumors.
Mingyue Jiang +19 more
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Hypoxia-Responsive Polymeric Micelles for Enhancing Cancer Treatment
Frontiers in Chemistry, 2020 Polymeric drug vectors have shown great potentials in cancer therapy. However, intelligent controlled release of drugs has become a major challenge in nanomedicine research.
Huayang Feng +8 more
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Frontiers in Chemistry, 2021 Chemotherapy is one of the commonly used therapies for the treatment of malignant tumors. Insufficient drug-loading capacity is the major challenge for polymeric micelle–based drug delivery systems of chemotherapy.
Man Zhou +11 more
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