Results 21 to 30 of about 59,311 (300)
Drug Delivery, 2018 This study aims at preparing and optimizing lacidipine (LCDP) polymeric micelles using thin film hydration technique in order to overcome LCDP solubility-limited oral bioavailability. A two-factor three-level central composite face-centered design (CCFD)
Ahmed R. Fares +2 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2021 Preparation and application of sustainable polymers derived from renewable resources are of great significance. The aim of this study is to synthesize a kind of sustainable polymeric micelles from rosin and vegetable oils via atom transfer radical ...
Juan Yu +8 more
doaj +1 more source
Smart systems related to polypeptide sequences [PDF]
, 2016 Increasing interest for the application of polypeptide-based smart systems in the biomedical field has developed due to the advantages given by the peptidic sequence.
Franco García, María Lourdes +2 more
core +2 more sources
Polymeric micelles–mediated photodynamic therapy
, 2023 Polymeric micelles (PM) have been demonstrating high potential as multifunctional therapeutic nanoplatforms for anticancer photodynamic therapy (PDT). PM increase photosensitizer (PS) accumulation in tumor tissues, thus improving its antitumor effect. The development of PM responsive to endogenous (e.g., pH, reducing agents, and hypoxia) or exogenous ...
de Santana, Willian Max O.S. +4 more
openaire +2 more sources
Nanomaterials, 2018 The compound 5’-deoxy-5-fluorouridine (5’-DFUR) is a prodrug of the anti-tumor drug 5-fluorouracil (5-FU). Thymidine phosphorylase (TP) is an enzyme that can convert 5’-DFUR to its active form 5-FU and the expression of TP is ...
Alicia J. Sawdon +3 more
doaj +1 more source
Ars Pharmaceutica, 2020 Background: topical antiseptic agents have been used widely in normal skin and wound which is associated with side effects such as systemic toxicity. Objective: Iodine is a non-metallic agent with an antimicrobial property that is used in the clinic as ...
Behzad Sharif Makhmal Zadeh +1 more
doaj +1 more source
Biomedicines, 2022 Multifunctional fatty acid grafted polymeric micelles are an effective and promising approach for drug and gene delivery to the brain. An alternative approach to bypass the blood–brain barrier is administration through intranasal route.
Richard Nii Lante Lamptey +4 more
doaj +1 more source
Polymeric micelles as cutaneous drug delivery system in normal skin and dermatological disorders
Journal of Advanced Pharmaceutical Technology & Research, 2018 The easy accessibility of skin made dermal application, one of the approaches for local drug therapy. Effectiveness of topical drug application is depended on different parameters such as skin barrier properties, physicochemical properties of drug and ...
Behzad Sharif Makhmalzade +1 more
doaj +1 more source
pH-responsive polymeric micelles self-assembled from amphiphilic copolymer modified with lipid used as doxorubicin delivery carriers [PDF]
Royal Society Open Science, 2018 In the present study, a novel pH-responsive amphiphilic copolymer, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)] conjugated poly(β-amino esters) (DSPE-b-PEG-b-PAE-b-PEG-b-DSPE), was designed and successfully synthesized
Xin Xin Zhou +3 more
doaj +1 more source
PLoS ONE, 2019 Astaxanthin is a highly potent antioxidant which can be extracted from Haematococcus pluvialis when cultivated and induced at high stress conditions. Due to astaxanthin's hydrophobicity, methoxypolyethylene glycol-polycaprolactone (mPEG-PCL) copolymer ...
Jun Zhang, Ching-An Peng
doaj +1 more source