Results 71 to 80 of about 1,447 (174)

Synthetic Vesicle-Based Drug Delivery Systems for Oral Disease Therapy: Current Applications and Future Directions

Journal of Functional Biomaterials
Oral diseases such as dental caries, periodontitis, and oral cancer are prevalent and present significant challenges to global public health. Although these diseases are typically treated through procedures like dental preparation and resin filling ...
Pengjie Huang, Weichang Li, Jiezhong Guan, Yibing Jia, Dan Wang, Yurun Chen, Niu Xiao, Songyue Ou, Yan Wang, Bo Yang   +9 more
doaj   +1 more source

Polymersome Crack Film and Its Templating Function in Silica and Gold Deposition

Macromolecular Chemistry and Physics, Volume 227, Issue 13, 15 July 2026.
Polymersome dispersion self‐assembled from PEI‐b‐PPOZ block copolymer in aqueous media can be drop‐cast onto substrates to give cracked films. The cracked film served as an effective catalytic template for the hydrolytic polycondensation of TMOS, producing silica‐coated films that retained the original crack pattern. In addition, gold deposition on the
Yuya Saza, Riku Matsuda, Yohei Kawabata, Tomomasa Satou, Nobuyuki Matsuki, Ren‐Hua Jin   +5 more
wiley   +1 more source

Enzymatically triggered rupture of polymersomes [PDF]

Soft Matter, 2016
Polymersomes are robust vesicles made from di-block co-polymers. We have engineered a two step enzymatic cascade to trigger the release of contents from polymersomes, in which extravesicular glucose oxidase makes hydrogen peroxide, when then penetrates the membrane and is converted by entrapped catalase to oxygen, leading to vesicle failure.
Woo-Sik, Jang, Seung Chul, Park, Ellen H, Reed, Kevin P, Dooley, Samuel F, Wheeler, Daeyeon, Lee, Daniel A, Hammer   +6 more
openaire   +2 more sources

Advances in Polyethyleneimine‐Derived Nanoformulations

Small Science, Volume 6, Issue 7, July 2026.
This article illustrates the cytotoxic effects of polyethyleneimine (PEI) on cell membranes and mitochondria, the strategies employed to mitigate PEI‐associated toxicity through chemical modification, PEGylation, and structural optimization, and the major types of PEI‐based formulations developed for the delivery of therapeutic drugs, nucleic acids ...
Mohamed S. Attia, Mariusz Skwarczynski, Waleed M. Hussein   +2 more
wiley   +1 more source

Elucidating the Influence of Tumor Presence on the Polymersome Circulation Time in Mice

Pharmaceutics, 2019
The use of nanoparticles as tumor-targeting agents is steadily increasing, and the influence of nanoparticle characteristics such as size and stealthiness have been established for a large number of nanocarrier systems.
Robin M. de Kruijff, René Raavé, Annemarie Kip, Janneke Molkenboer-Kuenen, Stefan J. Roobol, Jeroen Essers, Sandra Heskamp, Antonia G. Denkova   +7 more
doaj   +1 more source

Current Perspectives on STING Agonists for Anticancer Drug Development

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
The molecular structures of STING agonists play a decisive role in regulating the STING pathway. Their distinct scaffolds and functional groups orchestrate receptor binding, conformational activation, and the subsequent immune response. ABSTRACT The cyclic GMP‐AMP (cGAS) synthase and stimulator of interferon genes signaling pathway plays a central role
Dilay Kahvecioglu Cicek
wiley   +1 more source

Near-Infrared Laser-Triggered, Self-Immolative Smart Polymersomes for in vivo Cancer Therapy

International Journal of Nanomedicine, 2020
Qing Tang,* Ping Hu,* Haibo Peng, Ning Zhang, Qiang Zheng, Yun He School of Pharmaceutical Sciences and Chongqing Key Laboratory of Natural Drug Research, Chongqing University, Chongqing 401331, People’s Republic of China*These authors contributed ...
Tang Q, Hu P, Peng H, Zhang N, Zheng Q, He Y   +5 more
doaj  

Programmable Enzymatic Reaction Network in Artificial Cell‐Like Polymersomes

Advanced Science
The ability to precisely control in vitro enzymatic reactions in synthetic cells plays a crucial role in the bottom‐up design of artificial cell models that can recapitulate the key cellular features and functions such as metabolism. However, integration
Hanjin Seo, Hyomin Lee
doaj   +1 more source

Click on Click: Click-Flavone Glycosides Encapsulated in Click-Functionalised Polymersomes for Glioblastoma Therapy

Pharmaceutics
In this study, three new 3,7-dihydroxyflavone (1) derivatives with different sugars were designed and synthesised by click chemistry. Click chemistry requires the previously modification of building blocks with azide and alkyne groups and therefore, the ...
Nuno M. Saraiva, Ana Alves, Ana Isabel Barbosa, Andreia Marinho, Salette Reis, Marta Correia-da-Silva, Paulo C. Costa   +6 more
doaj   +1 more source

Engineering Polymersomes for Diagnostics and Therapy

Advanced Healthcare Materials, 2018
AbstractEngineered polymer vesicles, termed as polymersomes, confer a flexibility to control their structure, properties, and functionality. Self‐assembly of amphiphilic copolymers leads to vesicles consisting of a hydrophobic bilayer membrane and hydrophilic core, each of which is loaded with a wide array of small and large molecules of interests.
Jiayu Leong, Jye Yng Teo, Vinay K. Aakalu, Yi Yan Yang, Hyunjoon Kong   +4 more
openaire   +3 more sources