Results 31 to 40 of about 62,432 (254)

Polymyxin E Induces Rapid Paenibacillus polymyxa Death by Damaging Cell Membrane while Ca2+ Can Protect Cells from Damage. [PDF]

PLoS ONE, 2015
Polymyxin E, produced by Paenibacillus polymyxa, is an important antibiotic normally against Gram-negative pathogens. In this study, we found that polymyxin E can kill its producer P.
Zhiliang Yu, Yuanning Cai, Wangrong Qin, Jianxun Lin, Juanping Qiu   +4 more
doaj   +1 more source

Prevention of donation-related infections: investigating the use of antibiotics in the decontamination of preservation fluid for organ transplantation

Frontiers in Cellular and Infection Microbiology
BackgroundDonation-related infections (DRIs), particularly those caused by carbapenem-resistant gram-negative bacteria (CRGNB), can have disastrous consequences because of their extensive drug resistance.
Yazhe Duan, Junhao Yu, Pei Zhang, Yuhong Li, Kewen Chen, Yanfeng Li, Yuxiang Wan, Kang Wu, Li Zeng, Yanhua Li, Mingxing Sui   +10 more
doaj   +1 more source

Polymyxin Induces Significant Transcriptomic Perturbations of Cellular Signalling Networks in Human Lung Epithelial Cells

Antibiotics, 2022
Inhaled polymyxins are increasingly used to treat pulmonary infections caused by multidrug-resistant Gram-negative pathogens. We have previously shown that apoptotic pathways, autophagy and oxidative stress are involved in polymyxin-induced toxicity in ...
Mengyao Li, Mohammad A. K. Azad, Maizbha U. Ahmed, Yan Zhu, Jiangning Song, Fanfan Zhou, Hak-Kim Chan, Tony Velkov, Qi Tony Zhou, Jian Li   +9 more
doaj   +1 more source

Nomenclature for renal replacement therapy and blood purification techniques in critically ill patients: practical applications [PDF]

, 2016
This article reports the conclusions of the second part of a consensus expert conference on the nomenclature of renal replacement therapy (RRT) techniques currently utilized to manage acute kidney injury and other organ dysfunction syndromes in ...
Bagshaw, S. M., Balducci, A., Baldwin, I., Barbarigo, F., Bellomo, R., Bellomo, Rinaldo, Braganã³, P., Braunsky, J., Calletti, F., Cerda, J., Cerda, Jorge, Chawla, L., De Gaudio, A. Raffaele, De Rosa, S., De Rosa, Silvia, Di Somma, S., Doi, K., Dosil Rosende, P., Emmett, M., Fecondini, L., Galavotti, D., Garzotto, F., Garzotto, Francesco, Gibney, N., Goldstein, S. L., Guadagni, G., Honore, Patrick M., Honorã, P., Hoste, E., Inadome, S., Kashani, K., Katz, N., Kellum, J., Kenley, R., Kobayashi, Y., Lannoy, J., Lewington, A., Lorenzin, Anna, Mariano, F., Mccullough, P. A., Mehta, R. L., Menneguerre, J., Mettifogo, M., Neri, M., Neri, Mauro, Ostermann, M., Pani, A., Payen, Didier, Pirazzoli, P., Pohlmeier, R., Pouchoulin, D., Ricci, Z., Ricci, Zaccaria, Ronco, C., Ronco, Claudio, Rosner, M., Samoni, Sara, Seamann, M., Shaw, A., Tolwani, A., Villa, G., Villa, Gianluca, Vincent, J. L., Vincent, Jean-Louis, Wendon, J., Wendon, Julia, Zaccaria, Marta   +66 more
core   +4 more sources

Pharmacodynamic evaluation of suppression of in vitro resistance in Acinetobacter baumannii strains using polymyxin B-based combination therapy

Scientific Reports, 2021
The emergence of polymyxin resistance in Gram-negative bacteria infections has motivated the use of combination therapy. This study determined the mutant selection window (MSW) of polymyxin B alone and in combination with meropenem and fosfomycin against
Nayara Helisandra Fedrigo, Danielle Rosani Shinohara, Josmar Mazucheli, Sheila Alexandra Belini Nishiyama, Floristher Elaine Carrara-Marroni, Frederico Severino Martins, Peijuan Zhu, Mingming Yu, Sherwin Kenneth B. Sy, Maria Cristina Bronharo Tognim   +9 more
doaj   +1 more source

Selective digestive or oropharyngeal decontamination and topical oropharyngeal chlorhexidine for prevention of death in general intensive care : systematic review and network meta-analysis [PDF]

, 2014
Peer reviewedPublisher ...
Glen, John, MacLennan, Graeme, Price, Richard, SuDDICU Collaboration   +3 more
core   +1 more source

Synergistic Killing of Polymyxin B in Combination With the Antineoplastic Drug Mitotane Against Polymyxin-Susceptible and -Resistant Acinetobacter baumannii: A Metabolomic Study

Frontiers in Pharmacology, 2018
Polymyxins are currently used as the last-resort antibiotics against multidrug-resistant Acinetobacter baumannii. As resistance to polymyxins emerges in A. baumannii with monotherapy, combination therapy is often the only remaining treatment option.
Thien B. Tran, Thien B. Tran, Phillip J. Bergen, Darren J. Creek, Tony Velkov, Tony Velkov, Jian Li   +6 more
doaj   +1 more source

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source

GATR-3, a Peptide That Eradicates Preformed Biofilms of Multidrug-Resistant Acinetobacter baumannii

Antibiotics, 2023
Acinetobacter baumannii is a gram-negative bacterium that causes hospital-acquired and opportunistic infections, resulting in pneumonia, sepsis, and severe wound infections that can be difficult to treat due to antimicrobial resistance and the formation ...
Monique L. van Hoek, Fahad M. Alsaab, Ashley M. Carpenter   +2 more
doaj   +1 more source

A breakthrough on Amanita phalloides poisoning: an effective antidotal effect by polymyxin B [PDF]

, 2015
Amanita phalloides is responsible for more than 90 % of mushroom-related fatalities, and no effective antidote is available. a-Amanitin, the main toxin of A. phalloides, inhibits RNA polymerase II (RNAP II), causing hepatic and kidney failure.
A Onufriev, A Zheleva, A Zheleva, Alexandra T. P. Carvalho, AP Zavascki, BD Beck, BK Wills, C Gao, CA Beelman, CN Broussard, CW Pinson, DA Bushnell, DA Case, Daniel F. A. R. Dourado, DJ Barbosa, DR Larson, E Kaya, Félix Carvalho, G Leclerc, G Vogel, GM Morris, I Dalle-Donne, I-M Chang, J Garcia, J Garcia, J Guhaniyogi, J He, J Ross, J Vetter, J Weiser, J Zhao, JB Mowry, JL Dores-Sousa, José Alberto Duarte, Juliana Garcia, KH Reuner, M Leist, M Mydlik, MA Koda-Kimble, Marcelo D. Arbo, Maria de Lourdes Bastos, MM Murr, P Poucheret, PA Kollman, Paula Baptista, PCK Cheung, Ricardo Jorge Dinis-Oliveira, Ricardo Silvestre, SM Schneider, SM Schneider, T Lawrence, T Wieland, T Wieland, TC Tong, Teresa Baltazar, V Fineschi, Vera Marisa Costa, XP Zhang, Y Yamaura, YF Zhao   +59 more
core   +1 more source