Results 51 to 60 of about 62,432 (254)

Peptides as potent antimicrobials tethered to a solid surface: Implications for medical devices [PDF]

, 2008
Medical devices are an integral part of therapeutic management; despite their importance, they carry a significant risk of microbial infection. Bacterial attachment to a medical device is established by a single, multiplying organism, leading to ...
Ahmed El-Ghannam, Dilhari DeAlmeida, Ivan A. Gonzalez, Kazi Islam, Raymond B. Yurko, Ronald C. Montelaro, Simon C. Watkins, Timothy A. Mietzner, XiXi Wong   +8 more
core   +1 more source

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

β-lactam-induced OMV release promotes polymyxin tolerance in Salmonella enterica sv. Typhi

Frontiers in Microbiology
The rise of multidrug-resistant bacteria is a global concern, leading to a renewed reliance on older antibiotics like polymyxins as a last resort. Polymyxins, cationic cyclic peptides synthesized nonribosomally, feature a hydrophobic acyl tail and ...
Pedro Marchant, Erika Vivanco, Andrés Silva, Jan Nevermann, Ignacio Fuentes, Boris Barrera, Carolina Otero, Iván L. Calderón, Fernando Gil, Juan A. Fuentes   +9 more
doaj   +1 more source

Rapid polymyxin NP test for the detection of polymyxin resistance mediated by the MCR-1/MCR-2 genes [PDF]

, 2018
The Rapid Polymyxin NP test has been recently developed to rapidly detect polymyxin resistance in Enterobacteriaceae. Here we evaluated this test for detecting MCR- 1/MCR-2-producing Enterobacteriaceae using a collection of 70 non-redundant strains ...
Decousser, Jean-Winoc, Dobias, Jan, Larpin, Yu, Madec, Jean-Yves, Nordmann, Patrice, Poirel, Laurent, Stephan, Roger   +6 more
core   +1 more source

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

Evaluation of the Clinical Systems for Polymyxin Susceptibility Testing of Clinical Gram-Negative Bacteria in China

Frontiers in Microbiology, 2021
ObjectivesThe performance of mainstream commercial antimicrobial susceptibility testing systems on polymyxins has not been well evaluated in China. In this study, three antimicrobial susceptibility testing systems were evaluated for polymyxin B and ...
Ying Zhu, Ying Zhu, Peiyao Jia, Peiyao Jia, Menglan Zhou, Jingjia Zhang, Ge Zhang, Wei Kang, Simeng Duan, Tong Wang, Yingchun Xu, Qiwen Yang   +11 more
doaj   +1 more source

ETEC colonisation factors disrupt the antigen presenting capacity of porcine intestinal dendritic cells [PDF]

, 2012
Enterotoxigenic E. coli (ETEC) are not only a major cause of diarrhoea in travellers to and children in developing countries, but also cause neonatal and postweaning diarrhoea in piglets, leading to a reduced feed conversion and a higher mortality rate ...
Baert, Kim, Devriendt, Bert, Luo, Yu
core  

Washout policies in long-term indwelling urinary catheterisation in adults [PDF]

, 2017
Background  People requiring long-term bladder draining with an indwelling catheter can experience catheter blockage. Regimens involving different solutions can be used to wash out catheters with the aim of preventing blockage.
Airaksinen, Andersson, Atkins, Bach, Bibby, Bruun, Capewell, Davies, Elliott, Elliott, Evans, Garibaldi, Gelman, Getliffe, Getliffe, Getliffe, Getliffe, Getliffe, Gould, Hagen, Hamory, Hesse, Hesse, Kennedy, Kennedy, King, Kohler-Ockmore, Kunin, Linsenmeyer, McNicoll, Meyers, Moore, Muncie, Padawer, Pellowe, Pomfret, Robertson, Roe, Ruwaldt, Saint, Sinclair, Stark, Stickler, Sørbye, Vainrub, Waites, Ware, Warren, Wilks, Zigmond   +49 more
core   +5 more sources

Precise Construction of an Antimicrobial Peptide Targeting Bacterial Cell Membranes Derived From Natural Peptides

Advanced Science, EarlyView.
An AMP (P 3‐3R‐8I) based on natural peptides, which can target bacterial cell membranes, was precisely constructed via amino acid mutation. P 3‐3R‐8I exhibits antibacterial capability which could be attributed to the ability of P 3‐3R‐8I to quickly penetrate bacterial cell membranes and then to bind to bacterial DNA.
Jiaqi Huang, Bohao Liu, Xingzhuo Zhu, Deqian Qiao, Sizhe Chen, Xiaoyan Zeng, Qingqing Yang, Zihuan Wei, Yinjuan Huang, Jizhao Wang, Guangjian Zhang, Qiuyu Gong   +11 more
wiley   +1 more source

Ceftazidime/avibactam Improves the Antibacterial Efficacy of Polymyxin B Against Polymyxin B Heteroresistant KPC-2-Producing Klebsiella pneumoniae and Hinders Emergence of Resistant Subpopulation in vitro

Frontiers in Microbiology, 2019
Due to the increasing multidrug resistance and limited antibiotics, polymyxin B revived as the last resort for the treatment of carbapenemase-producing Klebsiella pneumoniae (CRKP).
Xingyan Ma, Yuting He, Xuegao Yu, Yimei Cai, Jianming Zeng, Jianming Zeng, Renxin Cai, Renxin Cai, Yang Lu, Yang Lu, Liang Chen, Cha Chen, Cha Chen, Bin Huang   +13 more
doaj   +1 more source