Results 21 to 30 of about 58,749 (205)

Early use of polymyxin B reduces the mortality of carbapenem-resistant Klebsiella pneumoniae bloodstream infection

Brazilian Journal of Infectious Diseases, 2019
Polymyxin B is one of the last resort option for carbapenem-resistant Klebsiella pneumoniae (CRKP) bloodstream infection in China. Therefore, the timing of administration of polymyxin is frequently delayed.
Qiqiang Liang, Man Huang, Zhijiang Xu
doaj   +3 more sources

Metabolomics revealed mechanism for the synergistic effect of sulbactam, polymyxin-B and amikacin combination against Acinetobacter baumannii

Frontiers in Microbiology, 2023
IntroductionThe emergence of multidrug-resistant (MDR) Acinetobacter baumannii prompts clinicians to consider treating these infections with polymyxin combination.MethodsMetabolomic analysis was applied to investigate the synergistic effects of polymyxin-
Shixing Zhu, Jiali Yue, Xintong Wang, Jiayuan Zhang, Mingming Yu, Mingming Yu, Yuanchao Zhan, Yuanqi Zhu, Sherwin K. B. Sy, Zhihua Lv, Zhihua Lv   +10 more
doaj   +1 more source

SpxA1 and SpxA2 act coordinately to fine-tune stress responses and virulence in Streptococcus pyogenes [PDF]

, 2017
SpxA is a unique transcriptional regulator highly conserved among members of the phylum Firmicutes that binds RNA polymerase and can act as an antiactivator. Why some Firmicutes members have two highly similar SpxA paralogs is not understood.
Gary C. Port, Larry S. McDaniel, Michael G. Caparon, Paul R. Tumminello, Zachary T. Cusumano   +4 more
core   +7 more sources

Transcriptional responses of Burkholderia cenocepacia to polymyxin B in isogenic strains with diverse polymyxin B resistance phenotypes

BMC Genomics, 2011
Background Burkholderia cenocepacia is a Gram-negative opportunistic pathogen displaying high resistance to antimicrobial peptides and polymyxins. We identified mechanisms of resistance by analyzing transcriptional changes to polymyxin B treatment in ...
Molinaro Antonio, Clarke Chelsea, Di Lorenzo Flaviana, Loutet Slade A, Valvano Miguel A   +4 more
doaj   +1 more source

Clinical use of intravenous polymyxin B for the treatment of patients with multidrug-resistant Gram-negative bacterial infections: An evaluation of the current evidence

Journal of Global Antimicrobial Resistance, 2021
Objectives: The epidemic dimensions of the emergence of multidrug-resistant (MDR) Gram-negative bacterial infections have led to the revival of old antibiotics, including the polymyxins.
Matthew E. Falagas, Margarita Kyriakidou, Georgios L. Voulgaris, Filippos Vokos, Sevasti Politi, Konstantinos S. Kechagias   +5 more
doaj   +1 more source

A breakthrough on Amanita phalloides poisoning: an effective antidotal effect by polymyxin B [PDF]

, 2015
Amanita phalloides is responsible for more than 90 % of mushroom-related fatalities, and no effective antidote is available. a-Amanitin, the main toxin of A. phalloides, inhibits RNA polymerase II (RNAP II), causing hepatic and kidney failure.
A Onufriev, A Zheleva, A Zheleva, Alexandra T. P. Carvalho, AP Zavascki, BD Beck, BK Wills, C Gao, CA Beelman, CN Broussard, CW Pinson, DA Bushnell, DA Case, Daniel F. A. R. Dourado, DJ Barbosa, DR Larson, E Kaya, Félix Carvalho, G Leclerc, G Vogel, GM Morris, I Dalle-Donne, I-M Chang, J Garcia, J Garcia, J Guhaniyogi, J He, J Ross, J Vetter, J Weiser, J Zhao, JB Mowry, JL Dores-Sousa, José Alberto Duarte, Juliana Garcia, KH Reuner, M Leist, M Mydlik, MA Koda-Kimble, Marcelo D. Arbo, Maria de Lourdes Bastos, MM Murr, P Poucheret, PA Kollman, Paula Baptista, PCK Cheung, Ricardo Jorge Dinis-Oliveira, Ricardo Silvestre, SM Schneider, SM Schneider, T Lawrence, T Wieland, T Wieland, TC Tong, Teresa Baltazar, V Fineschi, Vera Marisa Costa, XP Zhang, Y Yamaura, YF Zhao   +59 more
core   +1 more source

Rapid Detection of Polymyxin-Resistant Enterobacteriaceae from Blood Cultures. [PDF]

, 2016
Enterobacterial strains resistant to polymyxins are being increasingly reported worldwide. The conventional methods for detection of colistin-resistant isolates such as broth microdilution remain time-consuming (24 to 48 h), and methods such as disc ...
Dubois, V., Jayol, A., Nordmann, P., Poirel, L.   +3 more
core   +2 more sources

Ceftazidime/avibactam Improves the Antibacterial Efficacy of Polymyxin B Against Polymyxin B Heteroresistant KPC-2-Producing Klebsiella pneumoniae and Hinders Emergence of Resistant Subpopulation in vitro

Frontiers in Microbiology, 2019
Due to the increasing multidrug resistance and limited antibiotics, polymyxin B revived as the last resort for the treatment of carbapenemase-producing Klebsiella pneumoniae (CRKP).
Xingyan Ma, Yuting He, Xuegao Yu, Yimei Cai, Jianming Zeng, Jianming Zeng, Renxin Cai, Renxin Cai, Yang Lu, Yang Lu, Liang Chen, Cha Chen, Cha Chen, Bin Huang   +13 more
doaj   +1 more source

Stimulation of a glycosyl-phosphatidylinositol-specific phospholipase by insulin and the sulfonylurea, glimepiride, in rat adipocytes depends on increased glucose transport [PDF]

, 1994
. Lipoprotein lipase (LPL) and glycolipidanchored cAMP-binding ectoprotein (Gcel) are modified by glycosyl-phosphatidylinositol (GPI) in rat adipocytes, however, the linkage is potentially unstable. Incubation of the cells with either insulin (0.1-30 nM)
Bandlow, Wolfhard, Dearey, Elisabeth Ann, Korndörfer, Andrea, Müller, Günter   +3 more
core   +3 more sources

Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in Pseudomonas aeruginosa

mSystems, 2019
Polymyxins are a last-line therapy against multidrug-resistant Pseudomonas aeruginosa; however, resistance to polymyxins has been increasingly reported.
Mei-Ling Han, Yan Zhu, Darren J. Creek, Yu-Wei Lin, Alina D. Gutu, Paul Hertzog, Tony Purcell, Hsin-Hui Shen, Samuel M. Moskowitz, Tony Velkov, Jian Li   +10 more
doaj   +3 more sources