Results 31 to 40 of about 41,111 (239)
Images of LLC-PK1 cells incubated with Lissamine rhodamine-polymyxin B (LRhod-polymyxin B). [PDF]
, 2016 Control cells incubated in physiological media (A), cells exposed to 75 μM LRhod-polymyxin B for 4 hours (B), cells exposed to 75 μM LRhod-PMB for 8 hours (C), and cells exposed to 75 μM LRhod-polymyxin B for 24 hours (D).
Edson Andrade Pessoa (2993853) +5 more
core +1 more source
Advances in BODIPY Derivatives for Antibacterial Phototherapy
Angewandte Chemie, EarlyView.This review systematically summarizes the design strategies and structure‐activity relationships of BODIPY‐based antibacterial phototherapy, covering molecular engineering of small‐molecule photosensitizers and nanoplatforms, bacterial targeting and carrier design, and discussing the challenges and future perspectives associated with clinical ...
Li Lv +9 more
wiley +2 more sources
Polymyxin B-Induced Kidney Injury Assessment of a Novel Formulation of Polymyxin B (VRP-034) in Rats [PDF]
, 2021 Despite the crucial role of Polymyxin-B in treating life-threatening gram-negative infections, its clinical utility is limited due to the risk of acute kidney injury.
Saransh Chaudhary +5 more
core +1 more source
Journal of Microbiology, Immunology and Infection, 2018 Background: With increasing prevalence and spread of multidrug resistant Gram-negative infections, parenteral polymyxins resurged in clinical practice.
Bahiah Ismail +5 more
doaj +1 more source
Antibiotics, 2022 Inhaled polymyxins are increasingly used to treat pulmonary infections caused by multidrug-resistant Gram-negative pathogens. We have previously shown that apoptotic pathways, autophagy and oxidative stress are involved in polymyxin-induced toxicity in ...
Mengyao Li +9 more
doaj +1 more source
Inactivation of Endotoxin by Polymyxin B [PDF]
Antimicrobial Agents and Chemotherapy, 1974 The limulus gelation assay was utilized to investigate endotoxin inactivation by a number of antibiotics in vitro. Endotoxin activity was sharply reduced by polymyxin B and sodium colistimethate. The effect of the polymyxin was not significantly inhibited by 0.001 M calcium or 90% serum.
openaire +2 more sources
Personalizing Polymyxin B dosing using an adaptive feedback control algorithm [PDF]
, 2018 Polymyxin B is used as an antibiotic of last resort for patients with multidrug-resistant Gram-negative bacterial infections; however, it carries a significant risk of nephrotoxicity.
Keith S. Kaye +13 more
core +1 more source
British Journal of Anaesthesia, 1979 The effects of the polypeptide antibiotic, polymyxin B, on myocardial contractility were studied in t;e isolated rat heart muscle. Five different doses of polymyxin B were tested. There were no changes in contractility with does ranging from the clinical therapeutic value to three times greater.
Y Z, Sohn, R L, Katz
openaire +2 more sources
Novel polymyxin derivatives are less cytotoxic than polymyxin B to renal proximal tubular cells [PDF]
, 2012 The emergence of very multiresistant Gram-negative bacterial strains has reinstated polymyxins (polymyxin B, colistin), pentacationic lipopeptides, in the therapy, in spite of their nephrotoxicity. Extensive tubular reabsorption concentrates polymyxin in
Denamur, Sophie +4 more
core +1 more source
BMC Microbiology, 2022 Background The heteroresistance of polymyxin B, a last-resort antibiotic used to treat many serious bacterial infections, may lead to antibiotic treatment failure.
Jun Li +6 more
doaj +1 more source