Results 21 to 30 of about 41,111 (239)

Metabolomics revealed mechanism for the synergistic effect of sulbactam, polymyxin-B and amikacin combination against Acinetobacter baumannii

Frontiers in Microbiology, 2023
IntroductionThe emergence of multidrug-resistant (MDR) Acinetobacter baumannii prompts clinicians to consider treating these infections with polymyxin combination.MethodsMetabolomic analysis was applied to investigate the synergistic effects of polymyxin-
Shixing Zhu, Jiali Yue, Xintong Wang, Jiayuan Zhang, Mingming Yu, Mingming Yu, Yuanchao Zhan, Yuanqi Zhu, Sherwin K. B. Sy, Zhihua Lv, Zhihua Lv   +10 more
doaj   +1 more source

Risk Factors and Outcomes for Isolation with Polymyxin B-Resistant Enterobacterales from 2018–2022: A Case-Control Study [PDF]

, 2023
Wenjuan Yan,1,* Jiaojiao Wu,2,* Shanmei Wang,1 Qi Zhang,1 Youhua Yuan,1 Nan Jing,1 Jiangfeng Zhang,1 Hangchan He,3 Yi Li1 1Department of Clinical Microbiology, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, People ...
Wu J, Li Y, Zhang J, Wang S, Jing N, He H, Yan W, Zhang Q, Yuan Y   +8 more
core  

Polymyxin B-related neurotoxicity: a brief case report [PDF]

, 2023
Polymyxin B and colistin are considered the last therapeutic option to treat infections caused by highly drug-resistant bacteria. However, their administration may lead to various adverse effects such as nephrotoxicity, neurotoxicity, and allergic ...
HALAÇLI, BURÇİN, Topeli, Arzu, Demirkan, Kutay, Bayraktar, Izgi   +3 more
core   +1 more source

Lipid Microenvironment Modulates the Pore-Forming Ability of Polymyxin B [PDF]

, 2022
The ability of polymyxin B, an antibiotic used to treat infections caused by multidrug-resistant Gram-negative bacteria as a last-line therapeutic option, to form ion pores in model membranes composed of various phospholipids and lipopolysaccharides was ...
Efimova, Svetlana S., Anastasiia A. Zakharova, Svetlana S. Efimova, Ostroumova, Olga S., Olga S. Ostroumova, Zakharova, Anastasiia A.   +5 more
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Ceftazidime/avibactam Improves the Antibacterial Efficacy of Polymyxin B Against Polymyxin B Heteroresistant KPC-2-Producing Klebsiella pneumoniae and Hinders Emergence of Resistant Subpopulation in vitro

Frontiers in Microbiology, 2019
Due to the increasing multidrug resistance and limited antibiotics, polymyxin B revived as the last resort for the treatment of carbapenemase-producing Klebsiella pneumoniae (CRKP).
Xingyan Ma, Yuting He, Xuegao Yu, Yimei Cai, Jianming Zeng, Jianming Zeng, Renxin Cai, Renxin Cai, Yang Lu, Yang Lu, Liang Chen, Cha Chen, Cha Chen, Bin Huang   +13 more
doaj   +1 more source

Polymyxin B binding sites in Escherichia coli as revealed by polymyxin B-gold labeling. [PDF]

, 1987
A complex of polymyxin B, bovine serum albumin, and colloidal gold was prepared and used for the ultrastructural localization of polymyxin B binding sites on thin sections of Epon-embedded Escherichia coli cells.
H Morioka, M Tachibana, M Machino, A Suganuma   +3 more
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Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in Pseudomonas aeruginosa

mSystems, 2019
Polymyxins are a last-line therapy against multidrug-resistant Pseudomonas aeruginosa; however, resistance to polymyxins has been increasingly reported.
Mei-Ling Han, Yan Zhu, Darren J. Creek, Yu-Wei Lin, Alina D. Gutu, Paul Hertzog, Tony Purcell, Hsin-Hui Shen, Samuel M. Moskowitz, Tony Velkov, Jian Li   +10 more
doaj   +3 more sources

Polymyxin B in Combination with Rifampin and Meropenem against Polymyxin B-Resistant KPC-Producing Klebsiella pneumoniae [PDF]

, 2016
Safe and effective therapies are urgently needed to treat polymyxin-resistant KPC-producing K. pneumoniae and suppress the emergence of resistance. We investigated the pharmacodynamics of polymyxin B, rifampin, and meropenem alone and as polymyxin B ...
Rao, Gauri G., Diep, John K., Russo, Thomas A., Sharma, Rajnikant, Covelli, Jenna, Bowers, Dana R., Jacobs, David M.   +6 more
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Polymyxin B and fusidic acid, a novel potent synergistic combination against Klebsiella pneumoniae and Escherichia coli isolates with polymyxin B resistance

Frontiers in Microbiology, 2023
The increasing prevalence of multidrug-resistant (MDR) Gram-negative bacteria and comparatively limited options of antibiotics pose a major threat to public health worldwide.
Shuying Chen, Peiyao Zhou, Chunyang Wu, Jie Wang, Ying Zhou, Jiao Zhang, Bingjie Wang, Huilin Zhao, Lulin Rao, Meilan Li, Fangyou Yu, Fangyou Yu, Chunchan Lin   +12 more
doaj   +1 more source

The Actions of Polymyxin B and Histamine on Ganglionic Transmission [PDF]

, 1972
The ganglionic effects of histamine and the histamine-liberating agent polymyxin B were studied in the cat. Nictitating membrane contractions and postganglionic action potentials were used to monitor the actions of these drugs on the superior cervical ...
S. B. Gertner, H. E. Brezenoff
core   +1 more source