Results 21 to 30 of about 12,305,089 (195)

Polymyxin B-Induced Skin Hyperpigmentation

, 2020
Polymyxin B-induced skin hyperpigmentation is a rare adverse drug reaction (ADR). In this report, we present the case of a patient who underwent an abscess resection with right epididymitis, in which a multidrug-resistant Klebsiella pneumoniae infection (
Chunliu Luo, Xueke Wen, Weitao Lyu
core   +1 more source

Polymyxin B and fusidic acid, a novel potent synergistic combination against Klebsiella pneumoniae and Escherichia coli isolates with polymyxin B resistance

Frontiers in Microbiology, 2023
The increasing prevalence of multidrug-resistant (MDR) Gram-negative bacteria and comparatively limited options of antibiotics pose a major threat to public health worldwide.
Shuying Chen, Peiyao Zhou, Chunyang Wu, Jie Wang, Ying Zhou, Jiao Zhang, Bingjie Wang, Huilin Zhao, Lulin Rao, Meilan Li, Fangyou Yu, Fangyou Yu, Chunchan Lin   +12 more
doaj   +1 more source

Studies on the stability and activity of polymyxin B solutions. [PDF]

, 1997
The correlation between the chemical stability and the microbiological activity of polymyxin B in phosphate buffer pH 6.0 and in proprietary eye drops was evaluated.
Saohin, Wipawee
core   +7 more sources

Polymyxin B vs colistin: The comparison of neurotoxic and nephrotoxic effects of the two polymyxins

Journal of Global Antimicrobial Resistance
AIM: To compare polymyxin B with colistimethate sodium (CMS) regarding neurotoxicity, nephrotoxicity, and 30-day mortality in patients with multi-drug resistant (MDR) gram-negative.
Pınar Aysert Yıldız, Ozge Ozgen Top, Ahmet Furkan Senturk, Sait Kanık, H. Selcuk Ozger, Murat Dizbay   +5 more
doaj   +2 more sources

Polymyxin Induces Significant Transcriptomic Perturbations of Cellular Signalling Networks in Human Lung Epithelial Cells

Antibiotics, 2022
Inhaled polymyxins are increasingly used to treat pulmonary infections caused by multidrug-resistant Gram-negative pathogens. We have previously shown that apoptotic pathways, autophagy and oxidative stress are involved in polymyxin-induced toxicity in ...
Mengyao Li, Mohammad A. K. Azad, Maizbha U. Ahmed, Yan Zhu, Jiangning Song, Fanfan Zhou, Hak-Kim Chan, Tony Velkov, Qi Tony Zhou, Jian Li   +9 more
doaj   +1 more source

Predictors of polymyxin B treatment failure in Gram-negative healthcare-associated infections among critically ill patients

Journal of Microbiology, Immunology and Infection, 2018
Background: With increasing prevalence and spread of multidrug resistant Gram-negative infections, parenteral polymyxins resurged in clinical practice.
Bahiah Ismail, Mohd Nazri Shafei, Azian Harun, Saedah Ali, Mahamarowi Omar, Zakuan Zainy Deris   +5 more
doaj   +1 more source

Emergence of polymyxin B-heteroresistant hypervirulent Klebsiella pneumoniae from an individual in the community with asymptomatic bacteriuria

BMC Microbiology, 2022
Background The heteroresistance of polymyxin B, a last-resort antibiotic used to treat many serious bacterial infections, may lead to antibiotic treatment failure.
Jun Li, Mengli Tang, Fengjun Xia, Changhang Min, Yongmei Hu, Haichen Wang, Mingxiang Zou   +6 more
doaj   +1 more source

Polymyxin B binding sites in Escherichia coli as revealed by polymyxin B-gold labeling.

, 1987
A complex of polymyxin B, bovine serum albumin, and colloidal gold was prepared and used for the ultrastructural localization of polymyxin B binding sites on thin sections of Epon-embedded Escherichia coli cells.
H Morioka, M Tachibana, M Machino, A Suganuma   +3 more
core   +1 more source

Metabolomic profiling of polymyxin-B in combination with meropenem and sulbactam against multi-drug resistant Acinetobacter baumannii

Frontiers in Microbiology, 2022
Empirical therapies using polymyxins combined with other antibiotics are recommended in the treatment of Acinetobacter baumannii infections. In the present study, the synergistic activities of polymyxin-B, meropenem, and sulbactam as combination therapy ...
Shixing Zhu, Jiayuan Zhang, Chu Song, Yuwei Liu, Charles Oo, M. Tobias Heinrichs, Zhihua Lv, Zhihua Lv, Yuanqi Zhu, Sherwin K. B. Sy, Pan Deng, Mingming Yu, Mingming Yu   +12 more
doaj   +1 more source

POLYMYXIN B AND HEART MUSCLE

British Journal of Anaesthesia, 1979
The effects of the polypeptide antibiotic, polymyxin B, on myocardial contractility were studied in t;e isolated rat heart muscle. Five different doses of polymyxin B were tested. There were no changes in contractility with does ranging from the clinical therapeutic value to three times greater.
Y Z, Sohn, R L, Katz
openaire   +2 more sources