Results 41 to 50 of about 12,305,089 (195)
PharmaceuticsAccumulation of polymyxins in the lung epithelial cells can lead to increased mitochondrial oxidative stress and pulmonary toxicity. Aminoglycosides and polymyxins are used, via intravenous and pulmonary delivery, against multidrug-resistant Gram ...
Maizbha Uddin Ahmed +2 more
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Antibiotics, 2021 The emergence of mobile colistin resistance (mcr)-mediated polymyxin resistance has resulted in a significant detriment to the utility of the polymyxins in the clinical setting.
Nicholas M. Smith +3 more
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Images of LLC-PK1 cells incubated with Lissamine rhodamine-polymyxin B (LRhod-polymyxin B).
, 2016 Control cells incubated in physiological media (A), cells exposed to 75 μM LRhod-polymyxin B for 4 hours (B), cells exposed to 75 μM LRhod-PMB for 8 hours (C), and cells exposed to 75 μM LRhod-polymyxin B for 24 hours (D).
Edson Andrade Pessoa (2993853) +5 more
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Annals of Clinical Microbiology and Antimicrobials, 2018 Background The most important concern with polymyxins (Colistin and Polymyxin B) use is nephrotoxicity. There is no prospective data comparing nephrotoxicity of these two drugs, when administered in high doses and as per current recommendations.
Ritesh Aggarwal, Arun Dewan
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Polymyxin B-Induced Kidney Injury Assessment of a Novel Formulation of Polymyxin B (VRP-034) in Rats
, 2021 Despite the crucial role of Polymyxin-B in treating life-threatening gram-negative infections, its clinical utility is limited due to the risk of acute kidney injury.
Saransh Chaudhary +5 more
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Frontiers in Pharmacology, 2022 The latest PK/PD findings have demonstrated negligible efficacy of intravenous polymyxins against pulmonary infections. We investigated pharmacokinetic/pharmacodynamic (PK/PD)-based breakpoints of polymyxin B for bloodstream infections and the ...
Xingchen Bian +19 more
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Novel polymyxin derivatives are less cytotoxic than polymyxin B to renal proximal tubular cells
, 2012 The emergence of very multiresistant Gram-negative bacterial strains has reinstated polymyxins (polymyxin B, colistin), pentacationic lipopeptides, in the therapy, in spite of their nephrotoxicity. Extensive tubular reabsorption concentrates polymyxin in
Denamur, Sophie +4 more
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Polymyxin B broth disk elution as a screening test to determine polymyxin B susceptibility in enterobacterales [PDF]
, 2019 Detection of polymyxins susceptibility by clinical laboratories is a nightmare mainly because of physicochemical properties of the drug. The aim of this study was to evaluate accuracy of Polymyxin B Broth Disk Elution (PBDE), as screening test, compared ...
Cielo, Naiany Canabarro
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Регуляторные исследования и экспертиза лекарственных средствINTRODUCTION. Polymyxin B is a natural multicomponent antibiotic used in its sulfate form for the treatment of infections caused by multidrug-resistant Gram-negative bacteria. Pharmacopoeial standards for polymyxin B medicinal products include limits for
N. E. Kuz’mina +3 more
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BMC Microbiology, 2019 Background Although the most widely accepted mechanism of action for polymyxins is related to bacterial lysis via disruption, we hypothesized that this antimicrobial drug class could have other effects on Pseudomonas aeruginosa planktonic and sessile ...
Marlucy Rodrigues Lima +10 more
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