Results 41 to 50 of about 41,111 (239)
Frontiers in Microbiology, 2022 Empirical therapies using polymyxins combined with other antibiotics are recommended in the treatment of Acinetobacter baumannii infections. In the present study, the synergistic activities of polymyxin-B, meropenem, and sulbactam as combination therapy ...
Shixing Zhu +12 more
doaj +1 more source
Brazilian Journal of Infectious Diseases, 2018 A retrospective cohort study, were evaluated: polymyxin B plus aminoglycosides or polymyxin B plus other antibiotics. Any degree of acute kidney injury occurred in 26 (86.6%) patients.
Cely Saad Abboud +4 more
doaj +1 more source
Antibiotics, 2023 Fosfomycin disodium is a potential therapeutic option to manage difficult-to-treat infections, especially when combined with other antimicrobials. In this study, we evaluated the activity of fosfomycin in combination with meropenem or polymyxin B against
Aghata Cardoso da Silva Ribeiro +7 more
doaj +1 more source
The site of the neuromuscular block produced by polymyxin B and rolitetracycline [PDF]
, 1976 The site of neuromuscular blockade induced by polymyxin B and rolitetracycline was studied on isolated nerve and nerve–muscle preparations. Polymyxin B (1.8 × 10−4 M) was equipotent to lidocaine as a local anaesthetic on a frog desheathed nerve ...
B. Collier, J. M. Wright
core +1 more source
Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity
Advanced Science, EarlyView.We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu +17 more
wiley +1 more source
Polymyxin B interacts with the Psl extracellular matrix. [PDF]
, 2013 Images of WT PAO1, PA14, ΔpslAB, PBAD-psl, and CF127 biofilms subjected to 5 µg/ml fluorescent polymyxin B after 2 hours of exposure. Polymyxin B accumulates in the extracellular material of PBAD-psl and is less pronounced in WT PAO1 biofilms ...
Maria Ramirez Millan (443595) +6 more
core +1 more source
Risk factors for polymyxin B-associated acute kidney injury
International Journal of Infectious Diseases, 2022 Objectives: This study aimed to assess the current incidence and risk factors for polymyxin B-associated acute kidney injury (AKI) in Chinese hospitals for a more effective clinical use for polymyxin B.
Kang Chang +16 more
doaj +1 more source
Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity
Advanced Science, EarlyView.Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai +7 more
wiley +1 more source
Microbiology Spectrum, 2022 Polymyxin B is a last-line antibiotic for extensively resistant Gram-negative bacterial infection. Skin hyperpigmentation is a serious side effect induced by polymyxin B that severely compromises the psychological health and compliance of patients.
Chuhan Zhang +8 more
doaj +1 more source
Advanced Science, EarlyView.The genome of Rhodococcus erythropolis D‐1 was analyzed by bioinformatic tools to mine a novel nonribosomal peptide synthetase (NRPS) gene cluster. A nonribosomal peptide analog ZURJC5 associated with the NRPS was chemically synthesized. Through structure‐activity relationship studies, ZURJC28 was ultimately obtained and showed antibacterial activity ...
Keyi Chen +9 more
wiley +1 more source