Results 51 to 60 of about 12,305,089 (195)

Emergence of Polymyxin Resistance Driven by a PhoQ Mutation in KPC-2-Producing Klebsiella pneumoniae

Antibiotics
Background: The emergence of polymyxin-resistant, carbapenem-resistant Klebsiella pneumoniae (CRKP) presents a critical challenge to clinical management.
Huijuan Song, Cui Jian, Lu Gong, Ziyong Sun, Zhongju Chen, Yue Wang   +5 more
doaj   +1 more source

Risk Factors for Acute Kidney Injury Induced by Intravenous Polymyxin B in Chinese Patients with Severe Infection

Infection and Drug Resistance, 2022
Xuedong Jia,1,2 Cuohui Guo,1 Zhao Yin,1,2 Wan Zhang,1,2 Shuzhang Du,1,2 Xiaojian Zhang1,2 1Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China; 2The Precision Clinical Pharmacy Key ...
Jia X, Guo C, Yin Z, Zhang W, Du S, Zhang X   +5 more
doaj  

The site of the neuromuscular block produced by polymyxin B and rolitetracycline

, 1976
The site of neuromuscular blockade induced by polymyxin B and rolitetracycline was studied on isolated nerve and nerve–muscle preparations. Polymyxin B (1.8 × 10−4 M) was equipotent to lidocaine as a local anaesthetic on a frog desheathed nerve ...
B. Collier, J. M. Wright
core   +1 more source

Novel Polymyxin Combination With Antineoplastic Mitotane Improved the Bacterial Killing Against Polymyxin-Resistant Multidrug-Resistant Gram-Negative Pathogens

Frontiers in Microbiology, 2018
Due to limited new antibiotics, polymyxins are increasingly used to treat multidrug-resistant (MDR) Gram-negative bacteria, in particular carbapenem-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae.
Thien B. Tran, Thien B. Tran, Jiping Wang, Jiping Wang, Yohei Doi, Tony Velkov, Tony Velkov, Phillip J. Bergen, Phillip J. Bergen, Jian Li   +9 more
doaj   +1 more source

Risk Factors and Molecular Mechanism of Polymyxin B Resistance in Carbapenem-Resistant Klebsiella pneumoniae Isolates from a Tertiary Hospital in Fujian, China

Infection and Drug Resistance, 2022
Xiaohong Xu,1,* Rongping Zhu,1,* Siyan Lian,1 Hui Zhang,2 Xin Chen,2 Lingfang Fan,1 Peisong Chen,2 Yingping Cao1 1Department of Clinical Laboratory, Fujian Medical University Union Hospital, Fuzhou, Fujian, People’s Republic of China; 2Medical ...
Xu X, Zhu R, Lian S, Zhang H, Chen X, Fan L, Chen P, Cao Y   +7 more
doaj  

An Update on the arsenal for multidrug-resistant Acinetobacter infections: Polymyxin antibiotics

International Journal of Infectious Diseases, 2015
Objective: To review recent clinical pharmacokinetic and pharmacodynamic data to optimize dosing regimens for polymyxin B and colistin for treatment of infections due to A. baumannii.
Zahra Kassamali, Rupali Jain, Larry H. Danziger   +2 more
doaj   +1 more source

Polymyxin B interacts with the Psl extracellular matrix.

, 2013
Images of WT PAO1, PA14, ΔpslAB, PBAD-psl, and CF127 biofilms subjected to 5 µg/ml fluorescent polymyxin B after 2 hours of exposure. Polymyxin B accumulates in the extracellular material of PBAD-psl and is less pronounced in WT PAO1 biofilms ...
Maria Ramirez Millan (443595), Roberto Rusconi (443597), Marina Caldara (443596), Yekaterina Tarasova (407103), Katharina Ribbeck (249883), Nicole Billings (443594), Roman Stocker (224989)   +6 more
core   +1 more source

Pulmonary Target Delivery of Polymyxin B for Enhanced Efficacy

, 2012
Objective: Polymyxin B is increasingly used as the last resort for multidrug resistant (MDR) Gram-negative bacterial infections. Limited by high polarity of the drug and poor penetration into the pulmonary epithelial lining fluid (ELF), polymyxin B does ...
He, Jie 1981-
core   +1 more source

Synergistic effect of silver nanoparticles and polymyxin B against biofilm produced by Pseudomonas aeruginosa isolates of pus samples in vitro

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Pseudomonas aeruginosa (P. aeruginosa) is an aerobic gram-negative, non-spore forming, rod-shaped bacterium. It accelerates the decline in lung function and ultimately leads to increased mortality and morbidity rate.
Muhammad Salman, Rizwana Rizwana, Hayat Khan, Iqbal Munir, Muhammad Hamayun, Aquib Iqbal, Abdul Rehman, Khalid Amin, Ghayour Ahmed, Majid Khan, Ajmal Khan, Faiz Ul Amin   +11 more
doaj   +1 more source

Paradoxical Effect of Polymyxin B: High Drug Exposure Amplifies Resistance in Acinetobacter baumannii [PDF]

, 2016
Administering polymyxin antibiotics in a traditional fashion may be ineffective against Gram-negative ESKAPE ( Enterococcus faecium , Staphylococcus aureus , Klebsiella pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa , and Enterobacter ...
Nation, Roger L., Lenhard, Justin R., Rao, Gauri G., Cheah, Soon-Ee, Thamlikitkul, Visanu, Tsuji, Brian T., Landersdorfer, Cornelia B., Bulitta, Jürgen B., Holden, Patricia N., Forrest, Alan, Li, Jian   +10 more
core   +1 more source