Results 51 to 60 of about 41,111 (239)

Effectiveness and safety of polymyxin B for the treatment of infections caused by extensively drug-resistant Gram-negative bacteria in Thailand [PDF]

, 2018
Thundon Ngamprasertchai,1 Adhiratha Boonyasiri,2 Lantharita Charoenpong,3 Sireethorn Nimitvilai,4 Narisorn Lorchirachoonkul,5 Luksame Wattanamongkonsil,2 Visanu Thamlikitkul6 1Department of Clinical Tropical Medicine, Faculty of Tropical Medicine ...
Lorchirachoonkul N, Charoenpong L, Ngamprasertchai T, Boonyasiri A, Wattanamongkonsil L, Thamlikitkul V, Nimitvilai S   +6 more
core  

The action of polymyxin B at the frog neuromuscular juntion [PDF]

, 1981
The effects of polymyxin B at the neuromuscular junction of the frog were studied by conventional electrophysiological and voltage clamp techniques. At a concentration of 2.5 μg/ml polymyxin B produced neuromuscular blockade in 10 to 15 min and endplate ...
NICHOLAS N. DURANT, Durant, Nicholas N., Lambert, Jeremy J., JEREMY J. LAMBERT   +3 more
core   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Structure-function studies of polymyxin B lipononapeptides [PDF]

, 2019
The emerging threat of infections caused by highly drug-resistant bacteria has prompted a resurgence in the use of the lipodecapeptide antibiotics polymyxin B and colistin as last resort therapies.
Blaskovich, Mark, Hansford, Karl, Mark S. Butler, Matthew A. Cooper, Cooper, Matthew, Matthew A. Cooper, Mark A. T. Blaskovich, Johnny X. Huang, Johnny X. Huang, Mark S. Butler, Karl A. Hansford, Craig Muldoon, Elliott, Alysha, Alejandra Gallardo-Godoy, Ruby Pelingon, Karl A. Hansford, Butler, Mark, Mark A. T. Blaskovich, Bernd Becker, Huang, Johnny, Gallardo-Godoy, Alejandra, Muldoon, Craig, Alysha G. Elliott, Alysha G. Elliott, Pelingon, Ruby, Becker, Bernd   +25 more
core   +1 more source

Tobramycin Reduces Pulmonary Toxicity of Polymyxin B via Inhibiting the Megalin-Mediated Drug Uptake in the Human Lung Epithelial Cells

Pharmaceutics
Accumulation of polymyxins in the lung epithelial cells can lead to increased mitochondrial oxidative stress and pulmonary toxicity. Aminoglycosides and polymyxins are used, via intravenous and pulmonary delivery, against multidrug-resistant Gram ...
Maizbha Uddin Ahmed, Jian Li, Qi (Tony) Zhou   +2 more
doaj   +1 more source

Bacterial Mixology: Combining Pharmacodynamic Models to Predict In Vitro Competition of MCR-1-Harboring E. coli

Antibiotics, 2021
The emergence of mobile colistin resistance (mcr)-mediated polymyxin resistance has resulted in a significant detriment to the utility of the polymyxins in the clinical setting.
Nicholas M. Smith, Arthur Chan, Thomas D. Nguyen, Jacob T. Dumbleton   +3 more
doaj   +1 more source

Comparison of nephrotoxicity of Colistin with Polymyxin B administered in currently recommended doses: a prospective study

Annals of Clinical Microbiology and Antimicrobials, 2018
Background The most important concern with polymyxins (Colistin and Polymyxin B) use is nephrotoxicity. There is no prospective data comparing nephrotoxicity of these two drugs, when administered in high doses and as per current recommendations.
Ritesh Aggarwal, Arun Dewan
doaj   +1 more source

Exploring the Roles of Tuna‐Associated Acinetobacter sp. YFT067: Implications for Host Health and Metabolism

Animal Research and One Health, EarlyView.
This study firstly isolated a tuna‐derived gut probiotic Acinetobacter seifertii YFT067. Dietary administration of YFT067 played significant roles in promoting growth performance, SCFAs production, lipid absorption, and metabolism of the host, indicating YFT067 as a promising probiotic candidate for enhancing tuna aquaculture productivity through ...
Ying Zou, Hai Huang, Qiongyao Fu, Zhiyuan Lu, Zhiqiang Guo   +4 more
wiley   +1 more source

Table_1_Ceftazidime/avibactam Improves the Antibacterial Efficacy of Polymyxin B Against Polymyxin B Heteroresistant KPC-2-Producing Klebsiella pneumoniae and Hinders Emergence of Resistant Subpopulation in vitro.docx [PDF]

, 2019
Due to the increasing multidrug resistance and limited antibiotics, polymyxin B revived as the last resort for the treatment of carbapenemase-producing Klebsiella pneumoniae (CRKP).
Jianming Zeng (2138470), Bin Huang (331329), Xuegao Yu (7180088), Yang Lu (59885), Liang Chen (73736), Yimei Cai (52714), Renxin Cai (7339241), Yuting He (3821419), Xingyan Ma (7180097), Cha Chen (385771)   +9 more
core   +1 more source

Semi-mechanistic PK-PD modelling of combined polymyxin B and minocycline against a polymyxin-resistant strain of Acinetobacter baumannii [PDF]

, 2020
International audienceOBJECTIVES: The goal of this study was to expand on previous reports of synergy between polymyxin B and minocycline against Acinetobacter baumannii and gain insights on the qualitative and quantitative determinants of the synergy ...
Smani, Younes, Marchand, S., Aranzana-Climent, V., Buyck, Julien, Couet, W, Pachon-Diaz, J, Buyck, J. M., Pachón-Diaz, Jerónimo, Buyck, J M, Grégoire, Nicolas, Pachón, Jerónimo, Smani, Y, Grégoire, N., Gregoire, N, Couet, William, Aranzana-Climent, Vincent, Marchand, Sandrine, Couet, W., Aranzana-Climent, V, Marchand, S   +19 more
core   +1 more source