Results 71 to 80 of about 12,305,089 (195)

Characterization of Pharmacokinetics and Nephrotoxicity of Polymyxin B

, 2018
Objective: Increasing prevalence of multidrug resistant Gram-negative infections has led to renewed interest in the use of systemic polymyxin B. However, the pharmacological properties of polymyxin B are still poorly understood.
Abdelraouf, Kamilia
core  

Characterization of Pharmacokinetics and Nephrotoxicity of Polymyxin B

, 2012
Objective: Increasing prevalence of multidrug resistant Gram-negative infections has led to renewed interest in the use of systemic polymyxin B. However, the pharmacological properties of polymyxin B are still poorly understood.
Abdelraouf, Kamilia
core  

Nitazoxanide synergizes polymyxin B against Escherichia coli by depleting cellular energy

Microbiology Spectrum
The rapid expansion of antibiotic-resistant bacterial diseases is a global burden on public health. It makes sense to repurpose and reposition already-approved medications for use as supplementary agents in synergistic combinations with existing ...
Xuejia Jiang, Dongliang Chen, Xiaoyang Wang, Chunmei Wang, Haihong Zheng, Wenchong Ye, Wen Zhou, Guoping Liu, Keyu Zhang   +8 more
doaj   +1 more source

Polymyxin B inhibits contraction-stimulated glucose uptake in rat skeletal muscle

, 1991
Glucose transport in muscle is activated by contractile activity, an effect that persists in the postexercise state. Polymyxin B, a cyclic decapeptide antibiotic, inhibits the stimulation of glucose uptake in isolated muscle by contractile activity but ...
J. C. Young, T. G. Kurowski, A. M. Maurice, R. Nesher, N. B. Ruderman   +4 more
core   +1 more source

Intrathecal Injection of Polymyxin B in a Child with Meningitis Caused by Carbapenem-Resistant Pseudomonas aeruginosa: A Case Report and Literature Review

Mei Wu,1,2,* Jingui Zhao,1,2,* Zhongqiang Liu,1,2 Haiyang Zhang1,2 1Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Key Laboratory of Birth Defects and Related Diseases of
Wu M, Liu Z, Zhang H, Zhao J
core  

Pulmonary Target Delivery of Polymyxin B for Enhanced Efficacy

, 2018
Objective: Polymyxin B is increasingly used as the last resort for multidrug resistant (MDR) Gram-negative bacterial infections. Limited by high polarity of the drug and poor penetration into the pulmonary epithelial lining fluid (ELF), polymyxin B does ...
He, Jie 1981-
core  

SERUIVI LEVEL FOLLOWING BLADDER WASHOUT WITH POLYMYXIN-B [PDF]

, 1981
Polymyxin-B has an antimicrobial activity against gram-negative organisms including Pseudomonas aeruginosa. But the systemic use of the drug occurs in only rare occasions primarily because of its renal and neurotic toxicity.
合谷, 信行, 太田, 和夫, 東間, 紘   +2 more
core  

Table_2_Ceftazidime/avibactam Improves the Antibacterial Efficacy of Polymyxin B Against Polymyxin B Heteroresistant KPC-2-Producing Klebsiella pneumoniae and Hinders Emergence of Resistant Subpopulation in vitro.XLSX

, 2019
Due to the increasing multidrug resistance and limited antibiotics, polymyxin B revived as the last resort for the treatment of carbapenemase-producing Klebsiella pneumoniae (CRKP).
Jianming Zeng (2138470), Bin Huang (331329), Xuegao Yu (7180088), Yang Lu (59885), Liang Chen (73736), Yimei Cai (52714), Renxin Cai (7339241), Yuting He (3821419), Xingyan Ma (7180097), Cha Chen (385771)   +9 more
core   +1 more source

MIC breakpoints of XDR Enterobacterales Towards Polymyxin B, Colistin, and Tigecycline - Clinical Insights and Therapeutic Outcomes from A Descriptive Study

Journal of Pure and Applied Microbiology
The prevalence of antibiotic resistance among Gram-negative bacteria, particularly Enterobacterales, is rising. Extensively drug-resistant (XDR) Enterobacterales demonstrate nonsusceptibility to all except two or fewer classes of antibiotics, where it ...
R. Kalaivani, Arunava Kali, Joshy M. Easow   +2 more
doaj   +1 more source

Comparative efficacy of intravenous versus intravenous combined with intrathecal/intracerebral ventricle injection of polymyxin B for Acinetobacter baumannii intracranial infection: A retrospective study

Journal of Global Antimicrobial Resistance
Objective: Intracranial infections caused by Acinetobacter baumannii (A. baumannii) are common and life-threatening. This study aimed to compare the clinical efficacy and risk factors associated with 30-d mortality rates between intravenous (IV ...
Li You, Ru-meng Ding, Ting-ting Liu, Hai-yang Meng, Duo-lu Li   +4 more
doaj   +1 more source