Results 81 to 90 of about 41,111 (239)

Intrathecal Injection of Polymyxin B in a Child with Meningitis Caused by Carbapenem-Resistant Pseudomonas aeruginosa: A Case Report and Literature Review [PDF]

Mei Wu,1,2,* Jingui Zhao,1,2,* Zhongqiang Liu,1,2 Haiyang Zhang1,2 1Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Key Laboratory of Birth Defects and Related Diseases of
Wu M, Liu Z, Zhang H, Zhao J
core  

Paradoxical Effect of Polymyxin B: High Drug Exposure Amplifies Resistance in Acinetobacter baumannii [PDF]

, 2016
Administering polymyxin antibiotics in a traditional fashion may be ineffective against Gram-negative ESKAPE ( Enterococcus faecium , Staphylococcus aureus , Klebsiella pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa , and Enterobacter ...
Nation, Roger L., Lenhard, Justin R., Rao, Gauri G., Cheah, Soon-Ee, Thamlikitkul, Visanu, Tsuji, Brian T., Landersdorfer, Cornelia B., Bulitta, Jürgen B., Holden, Patricia N., Forrest, Alan, Li, Jian   +10 more
core   +2 more sources

Aptamer‐mediated outer membrane destabilization overcomes low permeability resistance in Pseudomonas aeruginosa

The FEBS Journal, EarlyView.
DNA aptamers, Apt 60 and Apt 173, target the BamA protein to compromise outer membrane integrity in Pseudomonas aeruginosa, making it susceptible to Azithromycin, an antibiotic that is otherwise poorly effective due to the low‐permeability membrane.
Rupany Selvam, Michelle Khai Khun Yap, Rafael Giacomazzi, Sérgio F. Sousa, Hock Siew Tan   +4 more
wiley   +1 more source

Pulmonary Target Delivery of Polymyxin B for Enhanced Efficacy [PDF]

, 2018
Objective: Polymyxin B is increasingly used as the last resort for multidrug resistant (MDR) Gram-negative bacterial infections. Limited by high polarity of the drug and poor penetration into the pulmonary epithelial lining fluid (ELF), polymyxin B does ...
He, Jie 1981-
core  

Transcriptomic responses of a New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae isolate to the combination of polymyxin B and chloramphenicol [PDF]

, 2020
The combination of polymyxins and chloramphenicol possesses synergistic killing activity against New Delhi metallo-β-lactamase (NDM)-producing Klebsiella pneumoniae.
Cheah, SE, Butler, MS, Nation, RL, Li, J, Johnson, MD, Paterson, DL, Boyce, JD, Yu, HH, Velkov, T, Cooper, MA, Fu, J, Abdul Rahim, N, Zhu, Y, Bergen, PJ, Sidjabat, HE   +14 more
core   +1 more source

Risk Factors and Molecular Mechanism of Polymyxin B Resistance in Carbapenem-Resistant Klebsiella pneumoniae Isolates from a Tertiary Hospital in Fujian, China

Infection and Drug Resistance, 2022
Xiaohong Xu,1,* Rongping Zhu,1,* Siyan Lian,1 Hui Zhang,2 Xin Chen,2 Lingfang Fan,1 Peisong Chen,2 Yingping Cao1 1Department of Clinical Laboratory, Fujian Medical University Union Hospital, Fuzhou, Fujian, People’s Republic of China; 2Medical ...
Xu X, Zhu R, Lian S, Zhang H, Chen X, Fan L, Chen P, Cao Y   +7 more
doaj  

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

The FEBS Journal, EarlyView.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu, Maximilian J. L. J. Fürst, Oscar P. Kuipers   +2 more
wiley   +1 more source

Emergence of Polymyxin Resistance Driven by a PhoQ Mutation in KPC-2-Producing Klebsiella pneumoniae

Antibiotics
Background: The emergence of polymyxin-resistant, carbapenem-resistant Klebsiella pneumoniae (CRKP) presents a critical challenge to clinical management.
Huijuan Song, Cui Jian, Lu Gong, Ziyong Sun, Zhongju Chen, Yue Wang   +5 more
doaj   +1 more source

Synergistic effect of silver nanoparticles and polymyxin B against biofilm produced by Pseudomonas aeruginosa isolates of pus samples in vitro

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Pseudomonas aeruginosa (P. aeruginosa) is an aerobic gram-negative, non-spore forming, rod-shaped bacterium. It accelerates the decline in lung function and ultimately leads to increased mortality and morbidity rate.
Muhammad Salman, Rizwana Rizwana, Hayat Khan, Iqbal Munir, Muhammad Hamayun, Aquib Iqbal, Abdul Rehman, Khalid Amin, Ghayour Ahmed, Majid Khan, Ajmal Khan, Faiz Ul Amin   +11 more
doaj   +1 more source

Clinical outcomes of lateral ear canal resection performed in routine clinical practice for chronic otitis externa in dogs: a retrospective descriptive study of 58 ears (2016‐2025)

Journal of Small Animal Practice, EarlyView.
Objectives To retrospectively evaluate the long‐term clinical outcomes of lateral ear canal resection performed as part of routine clinical practice for chronic otitis externa in dogs, and to re‐evaluate the practical utility of lateral ear canal resection from the perspective of contemporary treatment goals emphasising long‐term maintenance of a ...
K. Kiriki, A. Yabuzoe, K. Iyori
wiley   +1 more source