Results 11 to 20 of about 12,305,089 (195)

Transcriptional responses of Burkholderia cenocepacia to polymyxin B in isogenic strains with diverse polymyxin B resistance phenotypes [PDF]

BMC Genomics, 2011
Background Burkholderia cenocepacia is a Gram-negative opportunistic pathogen displaying high resistance to antimicrobial peptides and polymyxins. We identified mechanisms of resistance by analyzing transcriptional changes to polymyxin B treatment in ...
Molinaro Antonio, Clarke Chelsea, Di Lorenzo Flaviana, Loutet Slade A, Valvano Miguel A   +4 more
doaj   +3 more sources

Synergistic Killing of Polymyxin B in Combination With the Antineoplastic Drug Mitotane Against Polymyxin-Susceptible and -Resistant Acinetobacter baumannii: A Metabolomic Study [PDF]

Frontiers in Pharmacology, 2018
Polymyxins are currently used as the last-resort antibiotics against multidrug-resistant Acinetobacter baumannii. As resistance to polymyxins emerges in A. baumannii with monotherapy, combination therapy is often the only remaining treatment option.
Thien B. Tran, Thien B. Tran, Phillip J. Bergen, Darren J. Creek, Tony Velkov, Tony Velkov, Jian Li   +6 more
doaj   +3 more sources

Interactions of polymyxin B with lipopolysaccharide-containing membranes [PDF]

, 2021
Bacterial resistance to antibiotics constantly remodels the battlefront between infections and antibiotic therapy. Polymyxin B, a cationic peptide with an anti-Gram-negative spectrum of activity is re-entering use as a last resort measure and as an ...
Bonev, Boyan B., Goode, Alice, Yeh, Vivien   +2 more
core   +1 more source

Selective Reductive Cleavage of the Threonine 2 Peptide Bond of Penta-N-Boc-Polymyxin B with Sodium Borohydride [PDF]

, 2022
Sodium borohydride surprisingly cleaves the Threonine2 (Thr2) peptide bond in N-protected Polymyxin B. Occurring at 20 ºC, the mild reductive cleavage is novel; and it facilitates the synthesis of PMB-derived antibiotics.
Adriano, Afonso, Jay, Weinstein
core   +1 more source

Early use of polymyxin B reduces the mortality of carbapenem-resistant Klebsiella pneumoniae bloodstream infection

Brazilian Journal of Infectious Diseases, 2019
Polymyxin B is one of the last resort option for carbapenem-resistant Klebsiella pneumoniae (CRKP) bloodstream infection in China. Therefore, the timing of administration of polymyxin is frequently delayed.
Qiqiang Liang, Man Huang, Zhijiang Xu
doaj   +3 more sources

Metabolomics revealed mechanism for the synergistic effect of sulbactam, polymyxin-B and amikacin combination against Acinetobacter baumannii

Frontiers in Microbiology, 2023
IntroductionThe emergence of multidrug-resistant (MDR) Acinetobacter baumannii prompts clinicians to consider treating these infections with polymyxin combination.MethodsMetabolomic analysis was applied to investigate the synergistic effects of polymyxin-
Shixing Zhu, Jiali Yue, Xintong Wang, Jiayuan Zhang, Mingming Yu, Mingming Yu, Yuanchao Zhan, Yuanqi Zhu, Sherwin K. B. Sy, Zhihua Lv, Zhihua Lv   +10 more
doaj   +1 more source

Clinical use of intravenous polymyxin B for the treatment of patients with multidrug-resistant Gram-negative bacterial infections: An evaluation of the current evidence

Journal of Global Antimicrobial Resistance, 2021
Objectives: The epidemic dimensions of the emergence of multidrug-resistant (MDR) Gram-negative bacterial infections have led to the revival of old antibiotics, including the polymyxins.
Matthew E. Falagas, Margarita Kyriakidou, Georgios L. Voulgaris, Filippos Vokos, Sevasti Politi, Konstantinos S. Kechagias   +5 more
doaj   +1 more source

Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in Pseudomonas aeruginosa

mSystems, 2019
Polymyxins are a last-line therapy against multidrug-resistant Pseudomonas aeruginosa; however, resistance to polymyxins has been increasingly reported.
Mei-Ling Han, Yan Zhu, Darren J. Creek, Yu-Wei Lin, Alina D. Gutu, Paul Hertzog, Tony Purcell, Hsin-Hui Shen, Samuel M. Moskowitz, Tony Velkov, Jian Li   +10 more
doaj   +3 more sources

Ceftazidime/avibactam Improves the Antibacterial Efficacy of Polymyxin B Against Polymyxin B Heteroresistant KPC-2-Producing Klebsiella pneumoniae and Hinders Emergence of Resistant Subpopulation in vitro

Frontiers in Microbiology, 2019
Due to the increasing multidrug resistance and limited antibiotics, polymyxin B revived as the last resort for the treatment of carbapenemase-producing Klebsiella pneumoniae (CRKP).
Xingyan Ma, Yuting He, Xuegao Yu, Yimei Cai, Jianming Zeng, Jianming Zeng, Renxin Cai, Renxin Cai, Yang Lu, Yang Lu, Liang Chen, Cha Chen, Cha Chen, Bin Huang   +13 more
doaj   +1 more source

Polymyxin B in Combination with Rifampin and Meropenem against Polymyxin B-Resistant KPC-Producing Klebsiella pneumoniae [PDF]

, 2016
Safe and effective therapies are urgently needed to treat polymyxin-resistant KPC-producing K. pneumoniae and suppress the emergence of resistance. We investigated the pharmacodynamics of polymyxin B, rifampin, and meropenem alone and as polymyxin B ...
Rao, Gauri G., Diep, John K., Russo, Thomas A., Sharma, Rajnikant, Covelli, Jenna, Bowers, Dana R., Jacobs, David M.   +6 more
core   +1 more source