Results 21 to 30 of about 2,001 (190)
Driven translocation of a polynucleotide chain through a nanopore--A continuous time Monte-Carlo study [PDF]
Physical Review E74, 011911 (2006), 2006 Using continuous time Monte-Carlo method we simulated the translocation of a polynucleotide chain driven through a nanopore by an electric field. We have used two models of driven diffusion due to the electric field. The chain may have strong interaction with the pore, and depends on which end of the chain first enters the pore.
arxiv +1 more source
Remote Control of Eukaryotic Gene Expression by a Modular Ultrasound‐Responsive RNA Toolkit
Angewandte Chemie, EarlyView.A modular RNA‐based sonogenetic toolkit enables remote control of gene expression in eukaryotes by releasing small molecule modulators from ultrasound‐responsive carriers. These modulators activate engineered mRNA elements such as riboswitches, leading to tunable protein expression.
Fahimeh Charbgoo +7 more
wiley +2 more sources
Virus Replication as a Phenotypic Version of Polynucleotide Evolution [PDF]
Bulletin of Mathematical Biology, April 2013, Volume 75, Issue 4,
pp 602-628, 2012 In this paper we revisit and adapt to viral evolution an approach based on the theory of branching process advanced by Demetrius, Schuster and Sigmund ("Polynucleotide evolution and branching processes", Bull. Math. Biol. 46 (1985) 239-262), in their study of polynucleotide evolution.
arxiv +1 more source
Translocation of structured polynucleotides through nanopores [PDF]
Physical Biology 1 (2004) 19-26, 2003 We investigate theoretically the translocation of structured RNA/DNA molecules through narrow pores which allow single but not double strands to pass. The unzipping of basepaired regions within the molecules presents significant kinetic barriers for the translocation process.
arxiv +1 more source
Purification and Properties of a Polynucleotide Ligase from Human Cell Cultures [PDF]
European Journal of Biochemistry, 1971 A polynucleotide ligase has been detected and purified over 300‐fold from human cells cultured in vitro. The enzymic activity is dependent on ATP and Mg2+. The pH curve is bimodal with two optima at pH 7.5 and 8.1. The purified enzyme requires for its activity a heat‐resistant protein factor present in the crude extract.
Arturo Falaschi +2 more
openaire +3 more sources
Stochastic sensing of polynucleotides using patterned nanopores [PDF]
Phys. Rev. X 2, 021002 (2012), 2012 The effect of the microscopic structure of a pore on polymer translocation is studied using Langevin dynamics simulation, and the consequence of introducing patterned stickiness inside the pore is investigated. It is found that the translocation process is extremely sensitive to the detailed structure of such patterns with faster than exponential ...
arxiv +1 more source
On the Lubensky-Nelson model of polymer translocation through nanopores [PDF]
Biophys. J. 103, 889 (2012), 2012 We revisit the one-dimensional stochastic model of Lubensky and Nelson [Biophys. J 77, 1824 (1999)] for the electrically driven translocation of polynucleotides through alpha-hemolysin pores. We show that the model correctly describes two further important properties of the experimentally observed translocation time distributions, namely their spread ...
arxiv +1 more source
Bloch oscillations of a soliton in a molecular chain [PDF]
The European Physical Journal B, 55, 85-87 (2007), 2013 The paper presents results of numerical experiments simulating Bloch oscillations of solitons in a deformable molecular chain in a constant electric field. By the example of a homogeneous polynucleotide chain it is shown that the system under consideration can demonstrate complicated dynamical regimes when at the field intensities less than a certain ...
arxiv +1 more source
Exploring the Potential and Advancements of Circular RNA Therapeutics
Exploration, EarlyView.Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang +6 more
wiley +1 more source
E3-targetPred: Prediction of E3-Target Proteins Using Deep Latent Space Encoding [PDF]
arXiv, 2020 Understanding E3 ligase and target substrate interactions are important for cell biology and therapeutic development. However, experimental identification of E3 target relationships is not an easy task due to the labor-intensive nature of the experiments. In this article, a sequence-based E3-target prediction model is proposed for the first time.
arxiv