Results 21 to 30 of about 3,904 (190)

The ubiquitin E3/E4 ligase, UBE4A, fine-tunes protein ubiquitylation and accumulation at sites of DNA damage facilitating double-strand break repair [PDF]

, 2018
Double-strand breaks (DSBs) are critical DNA lesions that robustly activate the elaborate DNA damage response (DDR) network. We identified a critical player in DDR fine-tuning - the E3/E4 ubiquitin ligase, UBE4A.
Baranes Bachar, Keren, Huertas Sánchez, Pablo, Levy Barda, Adva, Oehler, Judith, Soria Bretones, Isabel   +4 more
core   +1 more source

Ribonucleolytic resection is required for repair of strand displaced nonhomologous end-joining intermediates [PDF]

, 2013
Nonhomologous end-joining (NHEJ) pathways repair DNA double-strand breaks (DSBs) in eukaryotes and many prokaryotes, although it is not reported to operate in the third domain of life, archaea. Here, we describe a complete NHEJ complex, consisting of DNA
Bartlett, Edward, Brissett, Nigel C, Doherty, Aidan J   +2 more
core   +1 more source

Evaluation of NAD(+)-dependent DNA ligase of mycobacteria as a potential target for antibiotics [PDF]

, 2007
Mycobacteria contain genes for several DNA ligases, including ligA, which encodes a NAD+-dependent enzyme that has been postulated to be a target for novel antibacterial compounds.
Bowater, Richard P., Brzostek, Anna, Dziadek, Jarosław, Korycka-Machala, Malgorzata, Rumijowska-Galewicz, Anna, Rychta, Ewelina, Sayer, Heather R.   +6 more
core   +2 more sources

Cleavage of 3′-terminal adenosine by archaeal ATP-dependent RNA ligase [PDF]

, 2017
Methanothermobacter thermoautotrophicus RNA ligase (MthRnl) catalyzes formation of phosphodiester bonds between the 5′-phosphate and 3′-hydroxyl termini of single-stranded RNAs.
Gollnick Paul, Ho C. Kiong, Liu Yancheng, Yoshinari Shigeo   +3 more
core   +3 more sources

Label-free electrochemical monitoring of DNA ligase activity [PDF]

, 2008
This study presents a simple, label-free electrochemical technique for the monitoring of DNA ligase activity. DNA ligases are enzymes that catalyze joining of breaks in the backbone of DNA and are of significant scientific interest due to their essential
Ahel I., Bellamy S. R., Borodina T. A., Bullard D. R., Cahova-Kucharikova K., Cao W. G., Doherty A. J., Fadrna R., Fojta M., Fojta M., Fojta M., Fojta M., Fojta M., Fojta M., Friedberg E. C., Gowers D. M., Heiter D. F., Kucharikova K., Liu L. F., Palecek E., Pascal J. M., Rass U., Schrock R. D., Scott B. O. S., Shuman S., Tomkinson A. E., Vacek J., Wilkinson A., Wilkinson A., Zauner G.   +29 more
core   +1 more source

Processing of Damaged DNA Ends for Double-Strand Break Repair in Mammalian Cells [PDF]

, 2012
Most DNA double-strand breaks (DSBs) formed in a natural environment have chemical modifications at or near the ends that preclude direct religation and require removal or other processing so that rejoining can proceed.
Povirk, Lawrence F.
core   +3 more sources

Structure and Function of a Mycobacterial NHEJ DNA Repair Polymerase [PDF]

, 2006
Non homologous end-joining (NHEJ)-mediated repair of DNA double-strand breaks in prokaryotes requires Ku and a specific multidomain DNA ligase (LigD).
Aidan J. Doherty, Angel J. Picher, Arezi, Augustin, Bowater, Chen, Chen, Critchlow, Daley, Darren Thompson, DeFazio, Della, Dominguez, Emsley, Garcia-Diaz, Gavin C. Fox, Gong, Gong, Ito, Iyer, Jones, Krejci, La Fortelle, Lao-Sirieix, Lao-Sirieix, Lipps, Luis Blanco, Ma, Ma, Mahajan, Matsumoto, McCoy, Murshudov, Nick McElhinney, Nick McElhinny, Nick McElhinny, Nigel C. Brissett, Paula Andrade, Paull, Picher, Pitcher, Pitcher, Potterton, Potterton, Powell, Prasad, Ramsden, Raquel Juarez, Robert S. Pitcher, Ruiz, Rydberg, Singhal, Steitz, Tseng, Weller, Wilson, Winn, Wu, Zhang, Zhu   +59 more
core   +1 more source

Therapeutic opportunities within the DNA damage response [PDF]

, 2015
The DNA damage response (DDR) is essential for maintaining the genomic integrity of the cell, and its disruption is one of the hallmarks of cancer.
A Chatr-Aryamontri, A Franceschini, A Franchitto, A Gaulton, AA Larrea, AC Antoniou, AE Tomkinson, AJ Bardin, AK Rustgi, AL Chambers, AL Marston, Amanda C. Schierz, AP Eker, AW Oliver, B Vogelstein, B Vogelstein, Bissan Al-Lazikani, C Greenman, C McWhirter, CA Lipinski, CJ Lord, CJ Richardson, D Croft, D Dorjsuren, DM van Pel, DM van Pel, DP Cahill, DW Parsons, E Kuhn, E Pastwa, EB Fauman, EC Friedberg, EK Bancroft, Frances M. G. Pearl, FS Collins, GH Nguyen, GM Kupfer, GP Pfeifer, H Panda, J Bartkova, J Zhang, JL Riffell, JM Daley, JM Murray, JM Paul, JN Weinstein, JP Overington, JW Harper, K Chang, KC Bulusu, KH Khoo, KH Lim, KK Hoe, KL Kanchi, L Galluzzi, L Weiss, Laurence H. Pearl, LB Alexandrov, LB Alexandrov, LJ Barber, LV Liu, M Aggarwal, M Ashburner, M Bastian, M D'Antonio, M Kanehisa, M Tischkowitz, ME Smoot, MN Patel, MS Lindstrom, NC Turner, NG Howlett, NG Jaspers, NJ Curtin, O Espinosa, P Bouwman, P Workman, PA Futreal, PA Janne, PV Hornbeck, Q Liang, R Brough, R Brough, R Buisson, R Mehra, R Nishi, RA Burrell, RE Verdun, S Prakash, SA Forbes, SA Martin, SI Nikolaev, Simon E. Ward, SL Allinson, SP Jackson, T Helleday, TD Halazonetis, TR Mereniuk, V Landre, WG Kaelin Jr., X Jacq, Y Nakazawa, YH Fan, Z Wang   +103 more
core   +1 more source

Capturing the ‘ome’ : the expanding molecular toolbox for RNA and DNA library construction [PDF]

, 2018
All sequencing experiments and most functional genomics screens rely on the generation of libraries to comprehensively capture pools of targeted sequences.
Boone, Morgane, Callewaert, Nico, De Koker, Andries   +2 more
core   +2 more sources

DNA DSB repair pathway choice: an orchestrated handover mechanism [PDF]

, 2014
DNA double strand breaks (DSBs) are potential lethal lesions but can also lead to chromosome rearrangements, a step promoting carcinogenesis. DNA non-homologous end-joining (NHEJ) is the major DSB rejoining process and occurs in all cell cycle stages ...
A Kakarougkas, Friedberg EC, Haynes RH, Jeggo PA, P A Jeggo, Wilson JH   +5 more
core   +1 more source