Insights Into Cockayne Syndrome Type B: What Underlies Its Pathogenesis?
Aging Cell, Volume 24, Issue 7, July 2025.Cockayne Syndrome complementation group B (CS‐B) is a highly debilitating progeroid syndrome that often culminates in the death of patients before adulthood. This review explores the pathogenesis of CS‐B and proposes that a combination of DNA damage accumulation, transcriptional dysregulation, and mitochondrial dysfunction is its underlying cause ...
Ricardo Afonso‐Reis +3 more
wiley +1 more source
Current advances in the role of classical non‐homologous end joining in hematologic malignancies
Clinical and Translational Discovery, Volume 5, Issue 3, June 2025.As depicted in the graphics, the classical NHEJ pathway can either take place in cells with DSBs or normal lymphocytes, reinforcing the stability of genome, and simultaneously maintaining the function of the immune system. While complete deletion causes immunodeficiency and tumourigenesis, some inhibitions could promote cancer therapies.
Pengcheng Liu, Zizhen Xu
wiley +1 more source
Enzymatic Joining of Polynucleotides
Journal of Biological Chemistry, 1972 Abstract Incubation of superhelical closed circular DNA with Escherichia coli DNA ligase and adenosine 5'-monophosphate (AMP) yields two new circular forms: molecules with one single strand break and covalently closed circles that have lost superhelical turns.
I. R. Lehman +2 more
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Inter-phylogenetic specificity in the bonding of amino acids to tRNA.
The Biological Bulletin, 1968 1. Amino acid activating enzymes (aminoacyl tRNA ligases) specific for valine and leucine tRNA have been partially purified from four widely differing phyla, namely yeast, E. coli, starfish and toadfish.2.
R. B. Loftfield, E. Eigner, J. Nobel
semanticscholar +1 more source
In VitroRepair of Single–strand Breaks in γ-irradiated DNA by Polynucleotide Ligase
International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1972 SummaryThe ability of polynucleotide ligase to eliminate single-strand breaks in γ-irradiated DNA was studied. The irradiated DNA was first labelled at the 5′-end of the break with 32P-phosphate and treated in vitro with polynucleotide ligase. In phosphoester-bonds joined by the ligase, the incorporated 32P-phosphate is resistant to subsequent ...
Jacobs, A., Bopp, A., Hagen, U.
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T4 bacteriophage-coded polynucleotide kinase and RNA ligase are involved in host tRNA alteration or repair [PDF]
, 1982 Michael David +2 more
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Enzymatic breakage and joining of deoxyribonucleic acid. II. The structural gene for polynucleotide ligase in bacteriophage T4. [PDF]
, 1967 George C. Fareed, C C Richardson
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The effect of antibiotics on the T4polynucleotide ligase catalyzed template dependent polymerization of oligodeoxythymidylates [PDF]
, 1979 Bernd W. Kalisch, Johan H. van de Sande
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Polynucleotide Ligase Activity in Cells Infected with Simian Virus 40, Polyoma Virus, or Vaccinia Virus [PDF]
, 1969 Joe Sambrook, Aaron J. Shatkin
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Polynucleotide Ligase Activity in Adenovirus-Infected Human Embryonic Kidney Cell Cultures
Experimental Biology and Medicine, 1970 SummaryCell-free extracts prepared from human embryonic kidney (HEK) cultures after infection with adenovirus 2 or 12 had a decreased ability to repair single-strand breaks in the HEK cell DNA substrate. The apparent loss of polynucleotide ligase activity found in infected cells may be related to the adenovirus-induced inhibition of HEK cell DNA ...
openaire +3 more sources