Results 31 to 40 of about 6,269 (253)

How hydrolytic exoribonucleases impact human disease: Two sides of the same story

FEBS Open Bio, Volume 13, Issue 6, Page 957-974, June 2023., 2023
Ribonucleases (or simply RNases) are the enzymes responsible for the processing and degradation of all types of RNAs, having multiple roles in every aspect of RNA metabolism. Here, we review what is known about the involvement of the RNase II/RNB family of 3′–5′ exoribonucleases in human disease.
Susana M. Costa, Margarida Saramago, Rute G. Matos, Cecília M. Arraiano, Sandra C. Viegas   +4 more
wiley   +1 more source

MSP1 encodes an essential RNA‐binding pentatricopeptide repeat factor required for nad1 maturation and complex I biogenesis in Arabidopsis mitochondria

New Phytologist, Volume 238, Issue 6, Page 2375-2392, June 2023., 2023
Summary Mitochondrial biogenesis relies on nuclearly encoded factors, which regulate the expression of the organellar‐encoded genes. Pentatricopeptide repeat (PPR) proteins constitute a major gene family in angiosperms that are pivotal in many aspects of mitochondrial (mt)RNA metabolism (e.g. trimming, splicing, or stability).
Corinne Best, Ron Mizrahi, Rana Edris, Hui Tang, Hagit Zer, Catherine Colas des Francs‐Small, Omri M. Finkel, Hongliang Zhu, Ian D. Small, Oren Ostersetzer‐Biran   +9 more
wiley   +1 more source

Streptomyces coelicolor polynucleotide phosphorylase can polymerize nucleoside diphosphates under phosphorolysis conditions, with implications for the degradation of structured RNAs. [PDF]

J Bacteriol, 2013
Jones GH, Mackie GA.
europepmc   +3 more sources

Adenovirus-mediated hPNPase(old-35) gene transfer as a therapeutic strategy for neuroblastoma [PDF]

, 2009
Current treatment options for neuroblastoma fail to eradicate the disease in the majority of high-risk patients, clearly mandating development of innovative therapeutic strategies. Gene therapy represents a promising approach for reversing the neoplastic
Ardelt, Arnold, Beck, Benito, Brodeur, Chan, Cinatl, Cinatl, D'Alessio, Hellemans, Holmes, Jasty, Kotchetkov, Lebedeva, Lebedeva, Leszczyniecka, Leszczyniecka, Maris, McConville, Michaelis, Pattyn, Pattyn, Ross, Sarkar, Sarkar, Sarkar, Sarkar, Sarkar, Sarkar, Su, Tweddle, Van Maerken, Vandesompele, Vandesompele, Vasandani, Vasandani, Youle, Young   +37 more
core   +2 more sources

Symbiont‐specific responses to environmental cues in a threesome lichen symbiosis

Molecular Ecology, Volume 32, Issue 5, Page 1045-1061, March 2023., 2023
Abstract Photosymbiodemes are a special case of lichen symbiosis where one lichenized fungus engages in symbiosis with two different photosynthetic partners, a cyanobacterium and a green alga, to develop two distinctly looking photomorphs. We compared gene expression of thallus sectors of the photosymbiodeme‐forming lichen Peltigera britannica ...
Jasmin Almer, Philipp Resl, Hörður Gudmundsson, Denis Warshan, Ólafur S. Andrésson, Silke Werth   +5 more
wiley   +1 more source

Prophage excision switches the primary ribosome rescue pathway and rescue‐associated gene regulations in Escherichia coli

Molecular Microbiology, Volume 119, Issue 1, Page 44-58, January 2023., 2023
In this study, we found that excision of Escherichia coli CP4‐57 prophage inactivates trans‐translation and activates the ArfA/RF2 rescue pathway back to back. This “rescue‐switching” rearranges the intercellular proteome landscape and E. coli phenotype in a rescue‐associated proteolysis‐dependent manner.
Haruka Onodera, Tatsuya Niwa, Hideki Taguchi, Yuhei Chadani   +3 more
wiley   +1 more source

The endoribonucleolytic N-terminal half of Escherichia coli RNase E is evolutionarily conserved in Synechocystis sp. and other bacteria but not the C-terminal half, which is sufficient for degradosome assembly [PDF]

, 1998
Escherichia coli RNase E, an essential single-stranded specific endoribonuclease, is required for both ribosomal RNA processing and the rapid degradation of mRNA.
Jakobsen, J.S., Kaberdin, V.R., Lin-Chao, S., McDowall, K.J., Miczak, A., Von Gabain, A.   +5 more
core   +2 more sources

Heterozygous PNPT1 Variants Cause Spinocerebellar Ataxia Type 25

Annals of Neurology, Volume 92, Issue 1, Page 122-137, July 2022., 2022
Objective Dominant spinocerebellar ataxias (SCA) are characterized by genetic heterogeneity. Some mapped and named loci remain without a causal gene identified. Here we applied next generation sequencing (NGS) to uncover the genetic etiology of the SCA25 locus.
Mathieu Barbier, Melanie Bahlo, Alessandra Pennisi, Maxime Jacoupy, Rick M. Tankard, Claire Ewenczyk, Kayli C. Davies, Patricia Lino‐Coulon, Claire Colace, Haloom Rafehi, Nicolas Auger, Brendan R. E. Ansell, Ivo van der Stelt, Katherine B. Howell, Marie Coutelier, David J. Amor, Emeline Mundwiller, Lena Guillot‐Noël, Elsdon Storey, R. J. McKinlay Gardner, Mathew J. Wallis, Alfredo Brusco, Olga Corti, Agnès Rötig, Richard J. Leventer, Alexis Brice, Martin B. Delatycki, Giovanni Stevanin, Paul J. Lockhart, Alexandra Durr   +29 more
wiley   +1 more source

Regulation and functions of bacterial PNPase [PDF]

, 2016
Polynucleotide phosphorylase (PNPase) is an exoribonuclease that catalyzes the processive phosphorolytic degradation of RNA from the 3\u2032-end. The enzyme catalyzes also the reverse reaction of polymerization of nucleoside diphosphates that has been ...
F. Briani, G. Dehò, T. Carzaniga
core   +1 more source

Assembly of multicomponent machines in RNA metabolism: A common theme in mRNA decay pathways

WIREs RNA, Volume 13, Issue 2, March/April 2022., 2022
Assembly of a multicomponent complex comprising a helicase, a ribonuclease, and a sensor to facilitate efficient RNA decay. The sensor can either be a component of the preassembled complex or be bound to the target RNA and recognized by the helicase‐ribonuclease assembly prior to degradation.
Alexandrina Machado de Amorim, Sutapa Chakrabarti   +1 more
wiley   +1 more source