Results 41 to 50 of about 16,842 (191)
European Journal of Immunology, Volume 56, Issue 4, April 2026.Investigation of IFN signaling in cultured skin fibroblasts from patients with genetically confirmed mitochondrial diseases of diverse origins revealed that altered IFN signaling is an inconsistent feature of these disorders. Cytosolic accumulation of mtDNA and mtRNA was variably detected and showed little correlation with ISG scores.
Manon Marchais +11 more
wiley +1 more source
Polynucleotide phosphorylase-deficient mutants of Pseudomonas putida
, 2003 In bacteria, polynucleotide phosphorylase (PNPase) is one of the main exonucleolytic activities involved in RNA turnover and is widely conserved. In spite of this, PNPase does not seem to be essential for growth if the organisms are not subjected to ...
G. Dehò, R. Favaro
core +1 more source
Defects of mitochondrial RNA turnover lead to the accumulation of double-stranded RNA in vivo.
PLoS Genetics, 2019 The RNA helicase SUV3 and the polynucleotide phosphorylase PNPase are involved in the degradation of mitochondrial mRNAs but their roles in vivo are not fully understood.
Aleksandra Pajak +12 more
doaj +1 more source
Localization of components of the RNA-degrading machine in Bacillus subtilis
Frontiers in Microbiology, 2016 In bacteria, the control of mRNA stability is crucial to allow rapid adaptation to changing conditions. In most bacteria, RNA degradation is catalyzed by the RNA degradosome, a protein complex composed of endo- and exoribonucleases, RNA helicases and ...
Nora Cascante-Estepa +2 more
doaj +1 more source
A PNPase dependent CRISPR System in Listeria. [PDF]
PLoS Genetics, 2014 The human bacterial pathogen Listeria monocytogenes is emerging as a model organism to study RNA-mediated regulation in pathogenic bacteria. A class of non-coding RNAs called CRISPRs (clustered regularly interspaced short palindromic repeats) has been ...
Nina Sesto +9 more
doaj +1 more source
mBio, 2022 The Bacillus subtilis genome encodes four 3′ exoribonucleases: polynucleotide phosphorylase (PNPase), RNase R, RNase PH, and YhaM. Previous work showed that PNPase, encoded by the pnpA gene, is the major 3′ exonuclease involved in mRNA turnover; in a ...
Shivani Chhabra +4 more
doaj +1 more source
Human FASTK preferentially binds single‐stranded and G‐rich RNA
The FEBS Journal, Volume 293, Issue 3, Page 729-748, February 2026.Although FASTK is known to play a role in mRNA biology, the mechanism through which it recognizes RNA has yet to be unraveled. Here, we used purified human FASTK to characterize its RNA‐binding properties in vitro. We found that FASTK prefers ssRNA oligonucleotides containing guanines with the potential to form G‐quadruplexes and binds robustly to any ...
Daria M. Dawidziak +7 more
wiley +1 more source
Characterization of the biochemical properties of Campylobacter jejuni RNase III
Bioscience Reports, 2013 Campylobacter jejuni is a foodborne bacterial pathogen, which is now considered as a leading cause of human bacterial gastroenteritis. The information regarding ribonucleases in C.
Nabila Haddad +4 more
doaj +1 more source
npj Biofilms and Microbiomes, 2023 Biofilms provide an environment that protects microorganisms from external stresses such as nutrient deprivation, antibiotic treatments, and immune defences, thereby creating favorable conditions for bacterial survival and pathogenesis. Here we show that
Ana Patrícia Quendera +6 more
doaj +1 more source
Small Science, Volume 5, Issue 12, December 2025.This review highlights the advances in graphene liquid cell designs for in situ liquid‐phase transmission electron microscopy, spanning veil‐type, well‐type, liquid‐flowing‐type, and mixing‐type configurations. These developments collectively enable real‐time visualization of diverse reactions in liquid environments at atomic resolution, thereby ...
Hyeonjong Ma +2 more
wiley +1 more source