Results 41 to 50 of about 6,571 (231)

A Novel Pathway of Functional microRNA Uptake and Mitochondria Delivery

Advanced Science, Volume 10, Issue 24, August 25, 2023., 2023
In the presence of serum, microRNAs (miRNAs) spontaneously form ≈110 nm nanoparticles, mediated bycationic proteins. When depleted, miRNA uptake is blocked. Unlike lysosome‐located, nanoparticle‐delivere mechanism are preferentially delivered to mitochondria of recipient cells by PNPT1.
Jiachen Liu, Weili Li, Jianfeng Li, Eli Song, Hongwei Liang, Weiwei Rong, Xinli Jiang, Nuo Xu, Wei Wang, Shuang Qu, Shouyong Gu, Yujing Zhang, Chen‐ Yu Zhang, Ke Zen   +13 more
wiley   +1 more source

How hydrolytic exoribonucleases impact human disease: Two sides of the same story

FEBS Open Bio, Volume 13, Issue 6, Page 957-974, June 2023., 2023
Ribonucleases (or simply RNases) are the enzymes responsible for the processing and degradation of all types of RNAs, having multiple roles in every aspect of RNA metabolism. Here, we review what is known about the involvement of the RNase II/RNB family of 3′–5′ exoribonucleases in human disease.
Susana M. Costa, Margarida Saramago, Rute G. Matos, Cecília M. Arraiano, Sandra C. Viegas   +4 more
wiley   +1 more source

MSP1 encodes an essential RNA‐binding pentatricopeptide repeat factor required for nad1 maturation and complex I biogenesis in Arabidopsis mitochondria

New Phytologist, Volume 238, Issue 6, Page 2375-2392, June 2023., 2023
Summary Mitochondrial biogenesis relies on nuclearly encoded factors, which regulate the expression of the organellar‐encoded genes. Pentatricopeptide repeat (PPR) proteins constitute a major gene family in angiosperms that are pivotal in many aspects of mitochondrial (mt)RNA metabolism (e.g. trimming, splicing, or stability).
Corinne Best, Ron Mizrahi, Rana Edris, Hui Tang, Hagit Zer, Catherine Colas des Francs‐Small, Omri M. Finkel, Hongliang Zhu, Ian D. Small, Oren Ostersetzer‐Biran   +9 more
wiley   +1 more source

Different csrA Expression Levels in C versus K-12 E. coli Strains Affect Biofilm Formation and Impact the Regulatory Mechanism Presided by the CsrB and CsrC Small RNAs

Microorganisms, 2021
Escherichia coli C is a strong biofilm producer in comparison to E. coli K-12 laboratory strains due to higher expression of the pgaABCD operon encoding the enzymes for the biosynthesis of the extracellular polysaccharide poly-β-1,6-N-acetylglucosamine ...
Thomas Carzaniga, Federica A. Falchi, Francesca Forti, Davide Antoniani, Paolo Landini, Federica Briani   +5 more
doaj   +1 more source

Lack of PNPase activity in Enterococcus faecalis 14 increases the stability of EntDD14 bacteriocin transcripts

Scientific Reports, 2023
A mutant deficient in polynucleotide phosphorylase (PNPase) activity was previously constructed in Enterococcus faecalis 14; a strain producing a leaderless two-peptide enterocin DD14 (EntDD14).
Rabia Ladjouzi, Anca Lucau-Danila, Paloma López, Djamel Drider   +3 more
doaj   +1 more source

Oocyte Factors Suppress Mitochondrial Polynucleotide Phosphorylase to Remodel the Metabolome and Enhance Reprogramming

Cell Reports, 2015
Oocyte factors not only drive somatic cell nuclear transfer reprogramming but also augment the efficiency and quality of induced pluripotent stem cell (iPSC) reprogramming.
Swea-Ling Khaw, Chua Min-Wen, Cheng-Gee Koh, Bing Lim, Ng Shyh-Chang   +4 more
doaj   +1 more source

The first step in the functional inactivation of the Escherichia coli polynucleotide phosphorylase messenger is a ribonuclease III processing at the 5′ end.

EMBO Journal, 1987
Claude Portier, L. Dondon, M. Grunberg‐Manago, Philippe Régnier   +3 more
openalex   +4 more sources

Enzymatic Synthesis and Fractionation of Fluorescent PolyU RNAs

Bio-Protocol, 2018
The physical properties of viral-length polyuridine (PolyU) RNAs, which cannot base-pair and form secondary structures, are compared with those of normal-composition RNAs, composed of comparable numbers of each of A, U, G and C nucleobases.
Christian Beren, Katherine Liu, Lisa Dreesens, Charles Knobler, William Gelbart   +4 more
doaj   +1 more source

Mitochondrial Genome Engineering: The Revolution May Not Be CRISPR-Ized. [PDF]

, 2018
In recent years mitochondrial DNA (mtDNA) has transitioned to greater prominence across diverse areas of biology and medicine. The recognition of mitochondria as a major biochemical hub, contributions of mitochondrial dysfunction to various diseases, and
Gammage, Payam A, Minczuk, Michal, Moraes, Carlos T   +2 more
core   +1 more source

Severo Ochoa and the Biomedical Sciences in Spain under Franco, 1959-1975 [PDF]

, 2000
The influence of Severo Ochoa in the establishment of biochemistry and molecular biology in Spain is the central topic of this essay. From the time he was awarded the Nobel Prize in Physiology or Medicine in 1959, Ochoa's links with Spanish scientists ...
Modigell, Michael, Pola, Annalisa, Suery, Michel, Zang, Christoph   +3 more
core   +1 more source