Life, 2019 The early metabolism arising in a Thioester world gave rise to amino acids and their simple peptides. The catalytic activity of these early simple peptides became instrumental in the transition from Thioester World to a Phosphate World.
Hyman Hartman, Temple F. Smith
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Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness. [PDF]
Int J Mol SciPolynucleotides, complex molecules composed of nucleotides, have gained attention in aesthetic medicine for their potential to regulate gene expression and promote tissue regeneration.
Lee KWA +6 more
europepmc +2 more sources
Stochastic Sensing of Polynucleotides Using Patterned Nanopores [PDF]
Physical Review X, 2012 The effect of the microscopic structure of a pore on polymer translocation is studied using Langevin dynamics simulation, and the consequence of introducing patterned stickiness inside the pore is investigated.
Jack A. Cohen +2 more
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Granulomatous Reactions Following the Injection of Multiple Aesthetic Microimplants: A Complication Associated with Excessive Filler Exposure in a Predisposed Patient [PDF]
ReportsBackground and Clinical Significance: Granulomatous reactions are rare but clinically significant complications of aesthetic procedures involving dermal fillers, particularly in individuals with underlying immune dysregulation.
Marjorie Garcerant Tafur +1 more
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Paeonia lactiflora Callus-Derived Polynucleotides Enhance Collagen Accumulation in Human Dermal Fibroblasts [PDF]
Journal of Functional BiomaterialsPlant-derived polynucleotides (PNs) have emerged as promising regenerative biomolecules; however, their mechanisms remain less defined than those of salmon-derived polydeoxyribonucleotides (S-PDRNs).
Soyoung Hwang +8 more
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Translocation of structured polynucleotides through nanopores [PDF]
Physical Biology, 2004 We investigate theoretically the translocation of structured RNA/DNA molecules through narrow pores which allow single but not double strands to pass. The unzipping of basepaired regions within the molecules presents significant kinetic barriers for the ...
Akeson M +20 more
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Tear Trough Rejuvenation With Injectable Biostimulatory Polynucleotides (VAMP) [PDF]
Plastic and Reconstructive Surgery, Global OpenSummary:. Tear trough rejuvenation presents a clinical challenge due to thin skin, superficial vasculature, and age-related volume loss. VAMP, manufactured by Prollenium, a polynucleotide-based biostimulatory injectable, is designed to support dermal ...
Noury Adel, MSc, DHM +5 more
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The promising potential of polynucleotide injections for knee osteoarthritis: A systematic review of literature and meta‐analysis of randomized control trials [PDF]
Journal of Experimental OrthopaedicsPurpose The present study aims to synthesize and evaluate the evidence on the effectiveness of intra‐articular polynucleotides (PNs) for knee osteoarthritis (OA). Methods In March 2024, we searched MEDLINE, Emcare, Web of Science and Cochrane Library for
Joseph Elphingstone +4 more
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Supersonic Cryogenic Jet Delivery of Polynucleotides Compared With Manual Intradermal Injection [PDF]
Plastic and Reconstructive Surgery, Global OpenBackground:. This study explores an alternative method of delivering polynucleotides (PNs) using a transdermal drug delivery device instead of traditional injection methods.
Michael Kim, MD +5 more
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Polynucleotide HPTTM-Based Hydrogels Exhibit Scavenging Activity Against Reactive Oxygen Species [PDF]
AntioxidantsThis study investigates the scavenger activity of Polynucleotide High Purification Technology (PN HPTTM), alone or in combination with hyaluronic acid (PN HPTTM + HA) against oxidative stress induced by hydrogen peroxide (H2O2). Since oxidative stress is
Maria Teresa Colangelo +3 more
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