Results 11 to 20 of about 38,341 (274)

Translocation of structured polynucleotides through nanopores [PDF]

Physical Biology 1 (2004) 19-26, 2003
We investigate theoretically the translocation of structured RNA/DNA molecules through narrow pores which allow single but not double strands to pass. The unzipping of basepaired regions within the molecules presents significant kinetic barriers for the translocation process.
U. Gerland, R. Bundschuh, T. Hwa
arxiv   +5 more sources

Current practices and perceived effectiveness of polynucleotides for treatment of facial erythema by cosmetic physicians. [PDF]

Skin Res Technol, 2023
Polynucleotides (PN) are increasingly used for the treatment of facial erythema in the Republic of Korea. However, there are limited pre‐clinical and clinical data on the efficacy of polynucleotides for facial erythema. In this study, we investigated the
Lee D, Kim MJ, Park HJ, Rah GC, Choi H, Anh ST, Ji GH, Kim MS, Kim G, Shin DW, Oh SM.   +10 more
europepmc   +2 more sources

Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness. [PDF]

Int J Mol Sci
Polynucleotides, complex molecules composed of nucleotides, have gained attention in aesthetic medicine for their potential to regulate gene expression and promote tissue regeneration.
Lee KWA, Chan KWL, Lee A, Lee CH, Wan J, Wong S, Yi KH.   +6 more
europepmc   +2 more sources

Combined Treatment with Polynucleotides and Hyaluronic Acid Improves Tissue Repair in Experimental Colitis

Biomedicines, 2020
Inflammatory bowel diseases (IBDs) are chronic conditions that can benefit from the combined treatment of adenosine receptor agonists and hyaluronic acid (HA), which, binding the CD44, has pro-survival effects.
Giovanni Pallio, Alessandra Bitto, Antonio Ieni, Natasha Irrera, Federica Mannino, Socrate Pallio, Domenica Altavilla, Francesco Squadrito, Carmelo Scarpignato, Letteria Minutoli   +9 more
doaj   +2 more sources

Origin of the Genetic Code Is Found at the Transition between a Thioester World of Peptides and the Phosphoester World of Polynucleotides

Life, 2019
The early metabolism arising in a Thioester world gave rise to amino acids and their simple peptides. The catalytic activity of these early simple peptides became instrumental in the transition from Thioester World to a Phosphate World.
Hyman Hartman, Temple F. Smith
doaj   +2 more sources

On the Lubensky-Nelson model of polymer translocation through nanopores [PDF]

Biophys. J. 103, 889 (2012), 2012
We revisit the one-dimensional stochastic model of Lubensky and Nelson [Biophys. J 77, 1824 (1999)] for the electrically driven translocation of polynucleotides through alpha-hemolysin pores. We show that the model correctly describes two further important properties of the experimentally observed translocation time distributions, namely their spread ...
Akeson, Aksimentiev, Andreas Meyer, Bates, Brun, Butler, Butler, Chen, Chen, Deamer, Dekker, Ghosal, Henrickson, Kafri, Kasianowicz, Li, Lindner, Lu, Lua, Lubensky, Luo, Maglia, Mathé, Meller, Meller, Meller, Meller, Milchev, Muthukumar, Muthukumar, Muzard, Parris, Peter Reimann, Purnell, Rabin, Reimann, Reimann, Reimann, Risken, Sebastian Getfert, Storm, Sung, Venkatesan, Wang, Wanunu, Wong, Zhang   +46 more
arxiv   +4 more sources

Pulling hairpinned polynucleotide chains: Does base-pair stacking interaction matter? [PDF]

J. Chem. Phys. 114, 8694-8700 (2001). AIP Copyright, 2001
Force-induced structural transitions both in relatively random and in designed single-stranded DNA (ssDNA) chains are studied theoretically. At high salt conditions, ssDNA forms compacted hairpin patterns stabilized by base-pairing and base-pair stacking interactions, and a threshold external force is needed to pull the hairpinned structure into a ...
Haijun Zhou, Moroz J. D., Yang Zhang
arxiv   +3 more sources

Driven Polymer Translocation Through a Narrow Pore [PDF]

, 1999
Motivated by experiments in which a polynucleotide is driven through a proteinaceous pore by an electric field, we study the diffusive motion of a polymer threaded through a narrow channel with which it may have strong interactions. We show that there is a range of polymer lengths in which the system is approximately translationally invariant, and we ...
Lubensky, David K., Nelson, David R.
arxiv   +5 more sources

An Innovative Lip Boosting Technique Using Polynucleotides: “4-point Cannula Technique” [PDF]

Plastic and Reconstructive Surgery, Global Open
Summary:. The new concept in aesthetic medicine is heading toward regenerative medicine and the use of skin boosters in our practice, so the present case report aimed to evaluate the efficacy of injecting a polynucleotide into the lips for lip ...
Noury Adel, MSc
doaj   +2 more sources

Phenanthridine–pyrene conjugates as fluorescent probes for DNA/RNA and an inactive mutant of dipeptidyl peptidase enzyme [PDF]

Beilstein Journal of Organic Chemistry, 2023
Two novel conjugate molecules were designed: pyrene and phenanthridine-amino acid units with a different linker length between the aromatic fragments. Molecular modelling combined with spectrophotometric experiments revealed that in neutral and acidic ...
Josipa Matić, Tana Tandarić, Marijana Radić Stojković, Filip Šupljika, Zrinka Karačić, Ana Tomašić Paić, Lucija Horvat, Robert Vianello, Lidija-Marija Tumir   +8 more
doaj   +2 more sources