Dry/Wet Cycling and the Thermodynamics and Kinetics of Prebiotic Polymer Synthesis
Life, 2016 The endoergic nature of protein and nucleic acid assembly in aqueous media presents two questions that are fundamental to the understanding of life’s origins: (i) how did the polymers arise in an aqueous prebiotic world; and (ii) once formed in some ...
David S. Ross, David Deamer
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Nature Communications, 2023 Modern cells are complex chemical compartments tightly regulated by an underlying DNA-encoded program. Achieving a form of coupling between molecular content, chemical reactions, and chassis in synthetic compartments represents a key step to the assembly
Tommaso P. Fraccia, Nicolas Martin
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How to Treat Skin Quality: A Consensus-Based Treatment Algorithm and Expert Guidance. [PDF]
J Cosmet DermatolABSTRACT Introduction Skin quality can be described using four emergent perceptual categories (EPCs): skin tone evenness, skin surface evenness, skin firmness, and skin glow. While the publication in which the EPCs were originally described by Goldie et al.
Kerscher M +11 more
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Molecular dynamics study on the mechanism of polynucleotide encapsulation by chitosan
Scientific Reports, 2017 The safe and effective delivery of therapeutic genes into target cell interiors is of great importance in gene therapy. Chitosan has been extensively studied as a gene delivery carrier due to its good biocompatibility and biodegradability.
Jia-Wei Shen +5 more
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INTRAARTICULAR KNEE JOINT INJECTION: HYALURONIC ACID VS POLYNUCLEOTIDES [PDF]
Euromediterranean Biomedical Journal, 2013 This study is a retrospective work of ambulatorial injections in patients suffering from Class II osteoarthritis (OA) of the knee. The research was conducted from January 2012 to July 2012 in a private clinic in Benevento, Hospital Val D'Elsa ...
Luigi Meccariello
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Intra-articular injections of polynucleotides for joint preconditioning before the injections of bionic cross-link hyaluronic acid. Case report [PDF]
Терапевтический архивThe article discusses intra-articular injections of polynucleotides (PN) for joint preconditioning before the injections of high-molecular-weight hyaluronic acid (HA) in the context of treating osteoarthritis (OA).
Irina S. Svintsitskaya +2 more
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Complexation of Oligo- and Polynucleotides with Methoxyphenyl-Functionalized Imidazolium Surfactants
Pharmaceutics, 2022 Interaction between cationic surfactants and nucleic acids attracts much attention due to the possibility of using such systems for gene delivery. Herein, the lipoplexes based on cationic surfactants with imidazolium head group bearing methoxyphenyl ...
Darya A. Kuznetsova +11 more
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Prebiotic selection for motifs in a model of template-free elongation of polymers within compartments. [PDF]
PLoS ONE, 2017 The transition from prelife where self-replication does not occur, to life which exhibits self-replication and evolution, has been a subject of interest for many decades. Membranes, forming compartments, seem to be a critical component of this transition
Grant Kinsler +3 more
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Theoretic Study on Dispersion Mechanism of Boron Nitride Nanotubes by Polynucleotides
Scientific Reports, 2016 Due to the unique electrical and mechanical properties of boron nitride nanotubes (BNNT), BNNT has been a promising material for many potential applications, especially in biomedical field.
Lijun Liang +3 more
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Ablation of keratan sulfate accelerates early phase pathogenesis of ALS. [PDF]
PLoS ONE, 2013 Biopolymers consist of three major classes, i.e., polynucleotides (DNA, RNA), polypeptides (proteins) and polysaccharides (sugar chains). It is widely accepted that polynucleotides and polypeptides play fundamental roles in the pathogenesis of ...
Kenichi Hirano +15 more
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