Molecular dynamics study on the mechanism of polynucleotide encapsulation by chitosan
Scientific Reports, 2017 The safe and effective delivery of therapeutic genes into target cell interiors is of great importance in gene therapy. Chitosan has been extensively studied as a gene delivery carrier due to its good biocompatibility and biodegradability.
Jia-Wei Shen +5 more
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INTRAARTICULAR KNEE JOINT INJECTION: HYALURONIC ACID VS POLYNUCLEOTIDES [PDF]
Euromediterranean Biomedical Journal, 2013 This study is a retrospective work of ambulatorial injections in patients suffering from Class II osteoarthritis (OA) of the knee. The research was conducted from January 2012 to July 2012 in a private clinic in Benevento, Hospital Val D'Elsa ...
Luigi Meccariello
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Interaction and Binding Modes of bis-Ruthenium(II) Complex to Synthetic DNAs
Metals, 2016 [μ-(linker)L2(dipyrido[3,2-a:2′,3′-c]phenazine)2(phenanthroline)2Ru(II)2]2+ with linker: 1,3-bis-(4-pyridyl)-propane, L: PF6 (bis-Ru-bpp) was synthesized and their binding properties to a various polynucleotides were investigated by spectroscopy ...
Hasi Rani Barai +3 more
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Complexation of Oligo- and Polynucleotides with Methoxyphenyl-Functionalized Imidazolium Surfactants
Pharmaceutics, 2022 Interaction between cationic surfactants and nucleic acids attracts much attention due to the possibility of using such systems for gene delivery. Herein, the lipoplexes based on cationic surfactants with imidazolium head group bearing methoxyphenyl ...
Darya A. Kuznetsova +11 more
doaj +1 more source
Prebiotic selection for motifs in a model of template-free elongation of polymers within compartments. [PDF]
PLoS ONE, 2017 The transition from prelife where self-replication does not occur, to life which exhibits self-replication and evolution, has been a subject of interest for many decades. Membranes, forming compartments, seem to be a critical component of this transition
Grant Kinsler +3 more
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Remote Control of Eukaryotic Gene Expression by a Modular Ultrasound‐Responsive RNA Toolkit
Angewandte Chemie, EarlyView.A modular RNA‐based sonogenetic toolkit enables remote control of gene expression in eukaryotes by releasing small molecule modulators from ultrasound‐responsive carriers. These modulators activate engineered mRNA elements such as riboswitches, leading to tunable protein expression.
Fahimeh Charbgoo +7 more
wiley +2 more sources
Intra-articular injections of polynucleotides for joint preconditioning before the injections of bionic cross-link hyaluronic acid. Case report [PDF]
Терапевтический архивThe article discusses intra-articular injections of polynucleotides (PN) for joint preconditioning before the injections of high-molecular-weight hyaluronic acid (HA) in the context of treating osteoarthritis (OA).
Irina S. Svintsitskaya +2 more
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Ablation of keratan sulfate accelerates early phase pathogenesis of ALS. [PDF]
PLoS ONE, 2013 Biopolymers consist of three major classes, i.e., polynucleotides (DNA, RNA), polypeptides (proteins) and polysaccharides (sugar chains). It is widely accepted that polynucleotides and polypeptides play fundamental roles in the pathogenesis of ...
Kenichi Hirano +15 more
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Biomolecules, 2021 New analogs of the commercial asymmetric monomethine cyanine dyes thiazole orange (TO) and thiazole orange homodimer (TOTO) with hydroxypropyl functionality were synthesized and their properties in the presence of different nucleic acids were studied ...
Ivana Mikulin +9 more
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Error Analysis of Chemically Synthesized Polynucleotides
BioTechniques, 1998 Two single-stranded polynucleotide constructs, 123 and 126 nucleotides in length, were chemically synthesized using standard phosphoramidite chemistry.
Karl H. Hecker, Randolph L. Rill
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