Results 31 to 40 of about 150 (94)

The Benzothiazine Core as a Novel Motif for DNA-Binding Small Molecules

Molecules, 2023
A new series of 4H-1,3-benzothiazine dyes were prepared and fully characterized in an aqueous medium. Benzothiazine salts were synthesized either through the classical synthetic pathway using Buchwald–Hartwig amination or through economical and ...
Milena Mlakić, Ivona Čipor, Petra Kovačec, Goran Kragol, Ana Ratković, Tatjana Kovačević, Rahela Zadravec, Valentina Milašinović, Krešimir Molčanov, Ivo Piantanida, Irena Škorić   +10 more
doaj   +1 more source

Stochastic Sensing of Polynucleotides Using Patterned Nanopores

Physical Review X, 2012
The effect of the microscopic structure of a pore on polymer translocation is studied using Langevin dynamics simulation, and the consequence of introducing patterned stickiness inside the pore is investigated.
Jack A. Cohen, Abhishek Chaudhuri, Ramin Golestanian   +2 more
doaj   +1 more source

Sequencing intractable DNA to close microbial genomes. [PDF]

PLoS ONE, 2012
Advancement in high throughput DNA sequencing technologies has supported a rapid proliferation of microbial genome sequencing projects, providing the genetic blueprint for in-depth studies.
Richard A Hurt, Steven D Brown, Mircea Podar, Anthony V Palumbo, Dwayne A Elias   +4 more
doaj   +1 more source

A Review of Recent Developments in Biopolymer Nano-Based Drug Delivery Systems with Antioxidative Properties: Insights into the Last Five Years

Pharmaceutics
In recent years, biopolymer-based nano-drug delivery systems with antioxidative properties have gained significant attention in the field of pharmaceutical research. These systems offer promising strategies for targeted and controlled drug delivery while
Magdalena Stevanović, Nenad Filipović
doaj   +1 more source

Granulomatous Reactions Following the Injection of Multiple Aesthetic Microimplants: A Complication Associated with Excessive Filler Exposure in a Predisposed Patient

Reports
Background and Clinical Significance: Granulomatous reactions are rare but clinically significant complications of aesthetic procedures involving dermal fillers, particularly in individuals with underlying immune dysregulation.
Marjorie Garcerant Tafur, Carmen Rodríguez-Cerdeira   +1 more
doaj   +1 more source

In Vitro Evidence for Oral Soft Tissue Regenerative Effects of a Polynucleotide–Hyaluronan Formulation

Clinical and Experimental Dental Research
Objectives We aimed to investigate the effects of a polynucleotide–hyaluronan (PN–HA) formulation on human palatal fibroblasts (HPFs) and oral epithelial cells (OKF6/TERT‐2) to assess its potential application in oral soft tissue reconstructive ...
Ina Mladenova, Xiaoqing Song, Cristina Nica, Anton Sculean, Maria B. Asparuhova   +4 more
doaj   +1 more source

Polynucleotide HPT^TM-Based Hydrogels Exhibit Scavenging Activity Against Reactive Oxygen Species

Antioxidants
This study investigates the scavenger activity of Polynucleotide High Purification Technology (PN HPTTM), alone or in combination with hyaluronic acid (PN HPTTM + HA) against oxidative stress induced by hydrogen peroxide (H2O2). Since oxidative stress is
Maria Teresa Colangelo, Silvana Belletti, Stefano Guizzardi, Carlo Galli   +3 more
doaj   +1 more source

Fluorimetric and CD Recognition between Various ds-DNA/RNA Depends on a Cyanine Connectivity in Cyanine-guanidiniocarbonyl-pyrrole Conjugate

Molecules, 2020
Two novel isosteric conjugates of guanidiniocarbonyl-pyrrole and 6-bromo-TO (thiazole orange) were prepared, differing only in linker connectivity to cyanine (benzothiazole nitrogen vs. quinoline nitrogen).
Tamara Šmidlehner, Marta Košćak, Ksenija Božinović, Dragomira Majhen, Carsten Schmuck, Ivo Piantanida   +5 more
doaj   +1 more source

Phenanthridine–pyrene conjugates as fluorescent probes for DNA/RNA and an inactive mutant of dipeptidyl peptidase enzyme

Beilstein Journal of Organic Chemistry, 2023
Two novel conjugate molecules were designed: pyrene and phenanthridine-amino acid units with a different linker length between the aromatic fragments. Molecular modelling combined with spectrophotometric experiments revealed that in neutral and acidic ...
Josipa Matić, Tana Tandarić, Marijana Radić Stojković, Filip Šupljika, Zrinka Karačić, Ana Tomašić Paić, Lucija Horvat, Robert Vianello, Lidija-Marija Tumir   +8 more
doaj   +1 more source

Ribozyme Activity of RNA Nonenzymatically Polymerized from 3′,5′-Cyclic GMP

Entropy, 2013
3′,5′-Cyclic GMP spontaneously nonenzymatically polymerizes in a base-catalyzed reaction affording G oligonucleotides. When reacted with fully or partially sequence-complementary RNA (oligo C), the abiotically generated oligo G RNA displays a typical ...
Samanta Pino, Giovanna Costanzo, Alessandra Giorgi, Jiří Šponer, Judit E. Šponer, Ernesto Di Mauro   +5 more
doaj   +1 more source