DNA Renaturation at the Water-Phenol Interface [PDF]
, 2003 We study DNA adsorption and renaturation in a water-phenol two-phase system, with or without shaking. In very dilute solutions, single-stranded DNA is adsorbed at the interface in a salt-dependent manner.
121 +161 more
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Efficacy of Polynucleotide-Based Therapy in Atopic Dermatitis Management. [PDF]
J Cosmet DermatolABSTRACT Background Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by persistent itching, dryness, redness, and recurrent eczematous lesions, significantly impacting patients' quality of life and psychological well‐being.
Bae K +7 more
europepmc +2 more sources
INTRAARTICULAR KNEE JOINT INJECTION: HYALURONIC ACID VS POLYNUCLEOTIDES [PDF]
Euromediterranean Biomedical Journal, 2013 This study is a retrospective work of ambulatorial injections in patients suffering from Class II osteoarthritis (OA) of the knee. The research was conducted from January 2012 to July 2012 in a private clinic in Benevento, Hospital Val D'Elsa ...
Luigi Meccariello
doaj +1 more source
Regulation of metabolism by miR-378 [PDF]
, 2014 The present invention provides a method of regulating fatty acid metabolism in a cell by contacting the cell with a modulator of miR-378 and/or miR-378* activity or expression.
Carrer, Michele, Olson, Eric N.
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Complexation of Oligo- and Polynucleotides with Methoxyphenyl-Functionalized Imidazolium Surfactants
Pharmaceutics, 2022 Interaction between cationic surfactants and nucleic acids attracts much attention due to the possibility of using such systems for gene delivery. Herein, the lipoplexes based on cationic surfactants with imidazolium head group bearing methoxyphenyl ...
Darya A. Kuznetsova +11 more
doaj +1 more source
Nucleotides: Structure and Properties [PDF]
, 2005 Nucleotides consist of a nitrogen-containing base, a five-carbon sugar, and one or more phosphate groups. Cells contain many types of nucleotides, which play a central role in a wide variety of cellular processes, including metabolic regulation and the ...
Bowater, RP
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Carbethoxylation of Polynucleotides [PDF]
European Journal of Biochemistry, 1971 Diethyl pyrocarbonate has been shown to react with poly(A), poly(C) and poly(G) but poly(U) does not react. Diethyl pyrocarbonate appears to carbethoxylate amino groups on the bases. Poly(A) can bind one carbethoxy group per base but the binding capacity of poly(G) and poly(C) under non‐denaturing conditions is 0.32 and 0.23, respectively.
openaire +2 more sources
Covalent binding studies on the 14C-labeled antitumour compound 2,5-bis(1-aziridinyl)-1,4-benzoquinone. Involvement of semiquinone radical in binding to DNA, and binding to proteins and bacterial macromolecules in situ [PDF]
, 1990 2,5-Bis(1-aziridinyl)-1,4-benzoquinone (BABQ) is a compound from which several antitumour drugs are derived, such as Trenimone, Carboquone and Diaziquone (AZQ).
Egberink, Richard J.M. +5 more
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Interaction and Binding Modes of bis-Ruthenium(II) Complex to Synthetic DNAs
Metals, 2016 [μ-(linker)L2(dipyrido[3,2-a:2′,3′-c]phenazine)2(phenanthroline)2Ru(II)2]2+ with linker: 1,3-bis-(4-pyridyl)-propane, L: PF6 (bis-Ru-bpp) was synthesized and their binding properties to a various polynucleotides were investigated by spectroscopy ...
Hasi Rani Barai +3 more
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Prebiotic selection for motifs in a model of template-free elongation of polymers within compartments. [PDF]
PLoS ONE, 2017 The transition from prelife where self-replication does not occur, to life which exhibits self-replication and evolution, has been a subject of interest for many decades. Membranes, forming compartments, seem to be a critical component of this transition
Grant Kinsler +3 more
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