An onset model of mutually catalytic self-replicative systems formed by an assembly of polynucleotides [PDF]
, 2023 Self-replicability is the unique attribute observed in all the living organisms and the question how the life was physically initiated could be equivalent to the question how self-replicating informative polymers were formed in the abiotic material world.
arxiv +1 more source
Covalent binding studies on the 14C-labeled antitumour compound 2,5-bis(1-aziridinyl)-1,4-benzoquinone. Involvement of semiquinone radical in binding to DNA, and binding to proteins and bacterial macromolecules in situ [PDF]
, 1990 2,5-Bis(1-aziridinyl)-1,4-benzoquinone (BABQ) is a compound from which several antitumour drugs are derived, such as Trenimone, Carboquone and Diaziquone (AZQ).
Egberink, Richard J.M. +5 more
core +2 more sources
Raman depolarization ratios in RNA and DNA are sensitive for sugar-base coupling [PDF]
, 1995 Polarized and depolarized Raman spectra are obtained for a number of synthetic polynucleotides containing adenine, uracil, and thymine bases. The depolarization ratios are determined by two methods: (1) by dividing the -spectrum by the -spectrum and (2 ...
Benevides +17 more
core +3 more sources
Kinetic studies on the phosphorolysis of polynucleotides by polynucleotide phosphorylase
Journal of Biological Chemistry, 1975 The kinetics of the phosphorolysis of polynucleotide (as differentiated from oligonucleotide) by polynucleotide phosphorylase of Micrococcus luteus has been investigated. Double reciprocal plots of initial velocity against either inorganic phosphate or polynucleotide concentration are linear, and furthermore, the affinity of the enzyme for either ...
J Y Chou, P McPhie, M F Singer
openaire +2 more sources
Molecular dynamics study on the mechanism of polynucleotide encapsulation by chitosan
Scientific Reports, 2017 The safe and effective delivery of therapeutic genes into target cell interiors is of great importance in gene therapy. Chitosan has been extensively studied as a gene delivery carrier due to its good biocompatibility and biodegradability.
Jia-Wei Shen +5 more
doaj +1 more source
Driven translocation of a polynucleotide chain through a nanopore--A continuous time Monte-Carlo study [PDF]
Physical Review E74, 011911 (2006), 2006 Using continuous time Monte-Carlo method we simulated the translocation of a polynucleotide chain driven through a nanopore by an electric field. We have used two models of driven diffusion due to the electric field. The chain may have strong interaction with the pore, and depends on which end of the chain first enters the pore.
arxiv +1 more source
INTRAARTICULAR KNEE JOINT INJECTION: HYALURONIC ACID VS POLYNUCLEOTIDES [PDF]
Euromediterranean Biomedical Journal, 2013 This study is a retrospective work of ambulatorial injections in patients suffering from Class II osteoarthritis (OA) of the knee. The research was conducted from January 2012 to July 2012 in a private clinic in Benevento, Hospital Val D'Elsa ...
Luigi Meccariello
doaj +1 more source
Virus Replication as a Phenotypic Version of Polynucleotide Evolution [PDF]
Bulletin of Mathematical Biology, April 2013, Volume 75, Issue 4,
pp 602-628, 2012 In this paper we revisit and adapt to viral evolution an approach based on the theory of branching process advanced by Demetrius, Schuster and Sigmund ("Polynucleotide evolution and branching processes", Bull. Math. Biol. 46 (1985) 239-262), in their study of polynucleotide evolution.
arxiv +1 more source
Interaction and Binding Modes of bis-Ruthenium(II) Complex to Synthetic DNAs
Metals, 2016 [μ-(linker)L2(dipyrido[3,2-a:2′,3′-c]phenazine)2(phenanthroline)2Ru(II)2]2+ with linker: 1,3-bis-(4-pyridyl)-propane, L: PF6 (bis-Ru-bpp) was synthesized and their binding properties to a various polynucleotides were investigated by spectroscopy ...
Hasi Rani Barai +3 more
doaj +1 more source
Complexation of Oligo- and Polynucleotides with Methoxyphenyl-Functionalized Imidazolium Surfactants
Pharmaceutics, 2022 Interaction between cationic surfactants and nucleic acids attracts much attention due to the possibility of using such systems for gene delivery. Herein, the lipoplexes based on cationic surfactants with imidazolium head group bearing methoxyphenyl ...
Darya A. Kuznetsova +11 more
doaj +1 more source