Results 41 to 50 of about 38,341 (274)
Extreme accumulation of nucleotides in simulated hydrothermal pore systems [PDF]
, 2007 We simulate molecular transport in elongated hydrothermal pore systems influenced by a thermal gradient. We find extreme accumulation of molecules in a wide variety of plugged pores. The mechanism is able to provide highly concentrated single nucleotides,
Baaske, Philipp +5 more
core +2 more sources
Error Propagation in the Hypercycle [PDF]
, 1999 We study analytically the steady-state regime of a network of n error-prone self-replicating templates forming an asymmetric hypercycle and its error tail.
Campos, P. R. A. +2 more
core +2 more sources
Interaction of doxorubicin with polynucleotides. A spectroscopic study.
Biochemistry, 2014 The interaction of doxorubicin (DX) with model polynucleotides poly(dG-dC)·poly(dG-dC) (polyGC), poly(dA-dT)·poly(dA-dT) (polyAT), and calf thymus DNA has been studied by several spectroscopic techniques in phosphate buffer aqueous solutions.
M. Airoldi +4 more
semanticscholar +1 more source
Remote Control of Eukaryotic Gene Expression by a Modular Ultrasound‐Responsive RNA Toolkit
Angewandte Chemie, EarlyView.A modular RNA‐based sonogenetic toolkit enables remote control of gene expression in eukaryotes by releasing small molecule modulators from ultrasound‐responsive carriers. These modulators activate engineered mRNA elements such as riboswitches, leading to tunable protein expression.
Fahimeh Charbgoo +7 more
wiley +2 more sources
Intra-articular injections of polynucleotides for joint preconditioning before the injections of bionic cross-link hyaluronic acid. Case report [PDF]
Терапевтический архивThe article discusses intra-articular injections of polynucleotides (PN) for joint preconditioning before the injections of high-molecular-weight hyaluronic acid (HA) in the context of treating osteoarthritis (OA).
Irina S. Svintsitskaya +2 more
doaj +1 more source
Ablation of keratan sulfate accelerates early phase pathogenesis of ALS. [PDF]
PLoS ONE, 2013 Biopolymers consist of three major classes, i.e., polynucleotides (DNA, RNA), polypeptides (proteins) and polysaccharides (sugar chains). It is widely accepted that polynucleotides and polypeptides play fundamental roles in the pathogenesis of ...
Kenichi Hirano +15 more
doaj +1 more source
Biomolecules, 2021 New analogs of the commercial asymmetric monomethine cyanine dyes thiazole orange (TO) and thiazole orange homodimer (TOTO) with hydroxypropyl functionality were synthesized and their properties in the presence of different nucleic acids were studied ...
Ivana Mikulin +9 more
doaj +1 more source
Dual targeting of MIR-208 and MIR-499 in the treatment of cardiac disorders [PDF]
, 2014 The present invention provides a method of treating or preventing cardiac disorders in a subject in need thereof by inhibiting the expression or function of both miR-499 and miR-208 in the heart cells of the subject. In particular, specific protocols for
Olson, Eric S., van Rooij, Eva
core +1 more source
Enzymatic synthesis of biotin-labeled polynucleotides: novel nucleic acid affinity probes.
Proceedings of the National Academy of Sciences of the United States of America, 1981 Analogs of dUTP and UTP that contain a biotin molecule covalently bound to the C-5 position of the pyrimidine ring through an allylamine linker arm have been synthesized.
P. R. Langer, A. Waldrop, D. Ward
semanticscholar +1 more source
Error Analysis of Chemically Synthesized Polynucleotides
BioTechniques, 1998 Two single-stranded polynucleotide constructs, 123 and 126 nucleotides in length, were chemically synthesized using standard phosphoramidite chemistry.
Karl H. Hecker, Randolph L. Rill
doaj +1 more source