Results 71 to 80 of about 27,712 (217)

Lipids contribute to epigenetic control via chromatin structure and functions

ScienceOpen Research, 2015
Isolated cases of experimental evidence over the last few decades have shown that, where specifically tested, both prokaryotes and eukaryotes have specific lipid molecules bound to nucleoproteins of the genome.
Renad Zhdanov, Eric Schirmer, Anuroop Venkateswaran Venkatasubramani, Alastair Kerr, Elena Mandrou, Giovanny Rodriguez Blanco, Alexander Kagansky   +6 more
doaj   +1 more source

Naphthalene diimide–amino acid conjugates as novel fluorimetric and CD probes for differentiation between ds-DNA and ds-RNA

Beilstein Journal of Organic Chemistry, 2020
Two novel unnatural amino acids, prepared by linking a dicationic purple-coloured and fluorescent naphthalene diimide (NDI) at core position to amino acid side chains of variable length, strongly interacted with ds-DNA/RNA by threading intercalation ...
Annike Weißenstein, Myroslav O. Vysotsky, Ivo Piantanida, Frank Würthner   +3 more
doaj   +1 more source

Optimised Ribosome Profiling Reveals New Insights Into Translational Regulation in Synchronised Chlamydomonas reinhardtii Cultures

Plant, Cell &Environment, Volume 48, Issue 9, Page 6982-7000, September 2025.
ABSTRACT Deep sequencing of ribosome footprints, also known as ribosome profiling (Ribo‐seq), enables the quantification of mRNA translation and a comprehensive view of the translatome landscape. Here, we report an optimised Ribo‐seq protocol and analysis pipeline for the model green alga, Chlamydomonas reinhardtiii (Chlamydomonas).
Yen‐Ling Lin, Eva Yuhua Kuo, Shih‐Yi Wang, Chih‐Chi Lee, Su‐Chiung Fang   +4 more
wiley   +1 more source

Une étape de l'évolution chimique: la formation de polypeptides et de polynucléotides dans des conditions prébiotiques

CHIMIA, 1974
Owing to a suitable enzymatic equipment the living cell synthesizes macromolecular chains (proteins, nucleic acids, polysaccharides) which can be considered as condensation products of the corresponding difunctionnal monomers (amino acids, nucleotides ...
C. Sadron, A. Brack, G. Spach
doaj   +1 more source

Photodynamic Therapy and Dietary Antioxidants: A Dual Strategy for Genome Stability and DNA Damage Repair

Cancer Medicine, Volume 14, Issue 15, August 2025.
ABSTRACT Background Photodynamic therapy (PDT) is an emerging cancer treatment that relies on photosensitizers (PS) activated by specific light wavelengths to produce reactive oxygen species (ROS), effectively targeting malignant cells. However, ROS can also harm surrounding healthy tissues, necessitating strategies to reduce unintended DNA damage ...
J. P. Jose Merlin, Sheeja S. Rajan, Heidi Abrahamse   +2 more
wiley   +1 more source

A New DNA Repair-Related Platform for Pharmaceutical Outlook in Cancer Therapies: Ultrashort Single-Stranded Polynucleotides

Scientia Pharmaceutica, 2019
Thio- and cyano- modified single-stranded poly(dNTP) sequences of different molecular sizes (20−200 n) and the same lengths routine poly(dNTP) and poly(NTP) species were tested for their impact on catalytic activities of β-like DNA polymerases
Sergey Stovbun, Kirill Ermakov, Alexander Bukhvostov, Alexander Vedenkin, Dmitry Kuznetsov   +4 more
doaj   +1 more source

Analytical Study of Lanolin as Potential Biomarker of Prehistoric Sheep‐Shearing Practice

Chemistry–Methods, Volume 5, Issue 8, August 2025.
Lanolin, a complex wax found on sheep wool, accumulates on shearing tools, such as flint and obsidian blades, used since the Neolithic. This study explores lanolin's degradation patterns as a potential biomarker for prehistoric sheep‐shearing practices, employing micro‐Fourier transformed infrared spectroscopy, hyperspectral imaging, and gas ...
Claudia Adsuar Fuster, Francesco Caruso, Olivia Gómez‐Laserna, Martina Romani, Ramón J. Barrio, Josep Maria Vergès, Vincenza Forgia, Maite Maguregui, Asier Vallejo   +8 more
wiley   +1 more source

Mesoscopic irreversible thermodynamics of aging kinetics of alpha polypeptides [DNA] under various constraints: Special reference to the simple spring mechanics

AIP Advances
The mesoscopic irreversible thermodynamic treatment of α-polypeptides and the helical polynucleotides (DNA) furnishes two sets of analytical expressions, which allow us not only to analyze the reversible force–extension experiments performed by atomic ...
Tarik Omer Ogurtani
doaj   +1 more source

Exploring the Potential and Advancements of Circular RNA Therapeutics

Exploration, Volume 5, Issue 4, August 2025.
Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang, Lianqing Wang, Chunbo Dong, Jialong Liu, Guoxin Cui, Shan Gao, Zhida Liu   +6 more
wiley   +1 more source

Prediction of Proliferation Rate of Pre‐Osteoblasts Using Raman Spectroscopy and Machine Learning Models

Journal of Raman Spectroscopy, Volume 56, Issue 8, Page 700-710, August 2025.
The main processes involved in predicting the pre–osteoblast proliferation rate using Raman spectroscopy and machine learning. ABSTRACT This novel study focuses on using Raman spectroscopy and machine learning (ML) models to forecast the murine pre‐osteoblast (OB) proliferation rate.
Sai S. Sudha, Angshuman Baradwaz, Ahmad Y. Javaid, Ambalangodage C. Jayasuriya   +3 more
wiley   +1 more source