Results 101 to 110 of about 3,053 (190)

Human polyomaviruses and cancer: an overview

Clinics, 2018
The name of the family Polyomaviridae, derives from the early observation that cells infected with murine polyomavirus induced multiple (poly) tumors (omas) in immunocompromised mice. Subsequent studies showed that many members of this family exhibit the
José Carlos Mann Prado, Telma Alves Monezi, Aline Teixeira Amorim, Vanesca Lino, Andressa Paladino, Enrique Boccardo   +5 more
doaj   +1 more source

Commentary on the Regulation of Viral Proteins in Autophagy Process [PDF]

, 2014
The ability to subvert intracellular antiviral defenses is necessary for virus to survive as its replication occurs only in the host cells. Viruses have to modulate cellular processes and antiviral mechanisms to their own advantage during the entire ...
Cheng, Ching-Yuan, Chi, Pei-I, Liu, Hung-Jen   +2 more
core   +3 more sources

RETRACTED: Association of partial infections with the risk of psoriasis: A two‐sample Mendelian randomization study

Skin Research and Technology, Volume 30, Issue 8, August 2024.
Abstract Background As a common chronic recurrent inflammatory skin disease, psoriasis is characterized by erythema and scaly skin lesions, with infection as an integral part of the pathogenesis of many diseases. Many previous cases reported the impact of psoriasis on infection.
Minghui Lu, Changyong Gao, Runtian Zhang, Lingling Yuan, Xi Chen, Boping Zhang   +5 more
wiley   +1 more source

Intratumoral injection of dendritic cells transduced by an SV40-based vector expressing interleukin-15 induces curative immunity mediated by CD8+ T lymphocytes and NK cells [PDF]

, 2005
Cancer immunotherapy has been extensively attempted by gene transfer of cytokines with viral vectors. In this work, we compared the therapeutic effects of interleukin 12 and 15 (IL-12 and IL-15) genes transferred to tumor cells or to dendritic cells (DCs)
Fortes, P. (Puri), González-Aseguinolaza, G. (Gloria), Melero, I. (Ignacio), Prieto, J. (Jesús), Razquin, N. (Nerea), Vera, M. (María)   +5 more
core   +1 more source

Merkel cell polyomavirus pan‐T antigen knockdown reduces cancer cell stemness and promotes neural differentiation independent of RB1

Journal of Medical Virology, Volume 96, Issue 7, July 2024.
Abstract Merkel cell carcinoma (MCC) is a highly aggressive skin cancer associated with integration of Merkel cell polyomavirus (MCPyV). MCPyV‐encoded T‐antigens (TAs) are pivotal for sustaining MCC's oncogenic phenotype, i.e., repression of TAs results in reactivation of the RB pathway and subsequent cell cycle arrest. However, the MCC cell line LoKe,
Kuan Cheok Lei, Nalini Srinivas, Mitalee Chandra, Thibault Kervarrec, Etienne Coyaud, Ivelina Spassova, Lukas Peiffer, Roland Houben, Masahiro Shuda, Daniel Hoffmann, David Schrama, Jürgen C. Becker   +11 more
wiley   +1 more source

Mucin Biopolymers As Broad-Spectrum Antiviral Agents [PDF]

, 2012
Mucus is a porous biopolymer matrix that coats all wet epithelia in the human body and serves as the first line of defense against many pathogenic bacteria and viruses.
Bergey E. J., Bergey E. J., Blixtjohansen G., Bloom J. D., Buck C. B., Buck C. B., Buck C. B., Celli J., Celli J. P., Chang Y., Chittum H. S., Christopher B. Buck, Cone R. A., Corinna Lieleg, Crater J. S., Day P. M., Duxbury A. J., Garcea R. L., Jesse Bloom, Kalluri R., Katharina Ribbeck, Lai S. K., Lai S. K., Lai S. K., Lieleg O., Lieleg O., Linden S. K., Loyo M., Mahalingam A., Mall A. S., Mall A. S., Matrosovich M. N., Matsui H., McGuckin M. A., Neumann G., Oliver Lieleg, Olmsted S. S., Pastrana D. V., Raynal B. D., Reid A. H., Roy A. M. M., Saltzman W. M., Schiffman M., Schiller J. T., Schilling J., Thornton D. J., Tian P., Varghese J. N., Wieland U., Yates J. R., Yolken R. H.   +50 more
core   +1 more source

Molecular epidemiology and risk factors associated with BK and JC polyomavirus urinary shedding after kidney allograft

Journal of Medical Virology, Volume 96, Issue 6, June 2024.
Abstract Polyomaviruses BK (BKPyV) and JC (JCPyV), belonging to the Polyomaviridae, are responsible for human pathologies. In kidney transplant recipients, BKPyV replication can lead to irreversible nephron damage whereas JCPyV replication remains asymptomatic.
Baptiste Demey, Aurélien Aubry, Véronique Descamps, Virginie Morel, My Hanh Hillary Le, Claire Presne, François Brazier, François Helle, Etienne Brochot   +8 more
wiley   +1 more source

Diversity and Evolution of Viral Pathogen Community in Cave Nectar Bats (Eonycteris spelaea)

Viruses, 2019
Bats are unique mammals, exhibit distinctive life history traits and have unique immunological approaches to suppression of viral diseases upon infection.
Ian H Mendenhall, Dolyce Low Hong Wen, Jayanthi Jayakumar, Vithiagaran Gunalan, Linfa Wang, Sebastian Mauer-Stroh, Yvonne C.F. Su, Gavin J.D. Smith   +7 more
doaj   +1 more source

Factors influencing the production of recombinant SV40 vectors [PDF]

, 2004
Most gene therapy approaches employ viral vectors for gene delivery. Ideally, these vectors should be produced at high titer and purity with well-established protocols.
Fortes, P. (Puri), Prieto, J. (Jesús), Strayer, D.S. (David S.), Vera, M. (María)   +3 more
core   +1 more source

High Torque teno virus load and outcome of patients undergoing allogeneic hematopoietic cell transplantation

Journal of Medical Virology, Volume 96, Issue 3, March 2024.
Abstract Quantification of Torque teno virus (TTV) load emerged as a marker of immunosuppression. Associations of TTV load with complications and survival after allogeneic hematopoietic cell transplantation (allo‐HCT) were controversial in published studies. In this prospective study, we aimed to identify factors influencing TTV load after allo‐HCT and
Micha Srour, Corentin Grenier, Leonardo Magro, Didier Hober, Ibrahim Yakoub‐Agha, Ilka Engelmann   +5 more
wiley   +1 more source