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Polyomavirus-associated nephropathy (PVAN) is an emerging cause of kidney transplant failure affecting 1-10% of patients. As uncertainty exists regarding risk factors, diagnosis, and intervention, an independent panel of experts reviewed the currently available evidence and prepared this report.
Hirsch HH +13 more
openaire +4 more sources
John Cunningham Virus (JCV) and BK Virus (BKV) are the most extensively studied Human Polyomaviruses (HPyVs), primarily associated with Progressive Multifocal Leukoencephalopathy (PML) and BKV Nephropathy (BKVN), respectively.
Sébastien Briol +5 more
doaj +2 more sources
BK polyomavirus-associated nephropathy in kidney transplant [PDF]
Two documented cases of BK polyomavirus-associated nephropathy (BKVN) seen at Hospital Edgardo Rebagliati Martins, EsSalud, Lima, Peru are reported. Final BKVN diagnosis was confirmed by renal biopsy and electron microscopy study. Case 1: Renal functional deterioration was not controlled despite reduction of immunosuppression and addition of antiviral ...
Méndez Chacón, Pedro +5 more
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Ultrasound findings of BK polyomavirus-associated nephropathy in renal transplant patients
BK polyomavirus (BKV) is an emerging pathogen in immunocompromised patients. BKV infection occurs in 1-9 % of renal transplants and causes chronic nephropathy or graft loss. Diagnosis of BKV-associated nephropathy (BKVAN) is based on detection of viruria then viremia and at least a tubule-interstitial nephritis at renal biopsy. This paper describes the
Mauro Dugo +11 more
openaire +4 more sources
BK Polyomavirus-Associated Nephropathy Complicated by Life-Threatening Hemorrhagic Pericardial Effusion Following Immunosuppression Reduction in a Kidney Transplant Recipient: A Case Report. [PDF]
Background BK polyomavirus (BKPyV) is an opportunistic infection following kidney transplantation due to immunosuppression. It is a recognized cause of tubulitis and graft dysfunction in kidney transplant recipients (KTRs). Management is challenging because clinicians must balance viral control with the risk of acute rejection.
Moradi H, Naimi A, Moeinzadeh F.
europepmc +2 more sources
Polyomavirus Associated Nephropathy: Frequency and Graft Survival Analysis in Northeast of Iran. [PDF]
Polyomavirus-associated nephropathy (PVAN), mainly caused by the BK virus, is one of the most important infectious complications of kidney transplantation. The leading histopathologic characteristics of PVAN is viral cytopathic effects, such as nucleomegaly with smudged or clumped chromatin and intranuclear ground-glass inclusion, mostly in tubular ...
Taraz Jamshidi S +7 more
europepmc +4 more sources
Polyomavirus-associated nephropathy. [PDF]
Polyomaviruses BK and JC are ubiquitous viruses with high seroprevalence rates in general population. Following primary infection, polyomaviruses BK and JC persist latently in different sites, particularly in the reno-urinary tract. Reactivation from latency may occur in normal subjects with asymptomatic viruria, while it can be associated to ...
Costa C, Cavallo R.
europepmc +4 more sources
Pathological characteristics of BK polyomavirus-associated nephropathy with glomerular involvement. [PDF]
This study aimed to investigate the pathological characteristics of BK polyomavirus (BKPyV)-associated nephropathy (BKPyVAN) with glomerular involvement in kidney transplant recipients.Forty-four patients with glomerular BKPyV infection were retrospectively included for analysis.
Chen XT +12 more
europepmc +4 more sources
Polyomavirus‐associated nephropathy: update in diagnosis [PDF]
Abstract: The histological diagnosis of BK or JC polyomavirus allograft nephritis (PVAN) requires evaluation of a renal biopsy with demonstration of the polyomavirus cytopathic changes and confirmation with an ancillary technique such as immunohistochemistry. Three histological patterns of PVAN (A, B, and C) are identified in renal biopsies. Pattern A
C B, Drachenberg, J C, Papadimitriou
openaire +2 more sources
BK polyomavirus (BKV) mainly causes infection in uroepithelial and renal tubular epithelial cells of either immunocompetent or immunocompromised hosts.
Wiwat Chancharoenthana +1 more
doaj +1 more source

