Results 21 to 30 of about 22,086 (184)
Phosphoinositide 3′-Kinase γ Facilitates Polyomavirus Infection
Viruses, 2020 Polyomaviruses are small, non-enveloped DNA tumor viruses that cause serious disease in immunosuppressed people, including progressive multifocal leukoencephalopathy (PML) in patients infected with JC polyomavirus, but the molecular events mediating ...
Paul Clark +6 more
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Microorganisms, 2021 Novel human polyomaviruses (HPyV) have been recently identified in solid organ transplant recipients. Trichodysplasia spinulosa (TS) is a rare disease associated with immunosuppression and induced by a polyomavirus (TSPyV).
Marie-Céline Zanella +5 more
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Microbiologia Medica, 2016 Polyomavirus-associated nephropathy is an important cause of allograft dysfunction and graft loss after kidney transplantation. Even if histological evaluation is the gold standard for graft study and diagnosis of polyomavirus-associated nephropathy, K ...
Antonio Curtoni +8 more
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Acquisition of Human Polyomaviruses in the First 18 Months of Life
Emerging Infectious Diseases, 2015 We investigated the presence of 4 human polyomaviruses (PyVs) (WU, KI, Merkel cell, and Malawi) in respiratory specimens from a community-based birth cohort. These viruses typically were acquired when children were ≈1 year of age.
Rebecca Rockett +10 more
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Polyomavirus miRNAs: the beginning [PDF]
Current Opinion in Virology, 2014 Polyomaviruses are small, double stranded DNA viruses that replicate in the nucleus of the infected cell. Since 2005, clear evidence for miRNAs has been presented for a subset of the members of this viral family, each of which express a single miRNA. All the miRNAs share in common the ability to regulate expression of the major viral regulatory protein,
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Seroprevalence of Human Malawi Polyomavirus [PDF]
Journal of Clinical Microbiology, 2014 ABSTRACT The seroprevalence of the recently discovered human Malawi polyomavirus (MWPyV) was determined by virus-like particle-based enzyme-linked immunosorbent assay (ELISA) in age-stratified Italian subjects. The findings indicated that MWPyV infection occurs early in life, and seroprevalence was shown to reach 42% in adulthood.
Jérôme TJ Nicol +7 more
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Journal for ImmunoTherapy of CancerThe cell adhesion protein CD56 has been identified as a potential therapeutic target in several solid tumors and hematological malignancies. Recently, we developed a CD56-directed antibody-drug conjugate (ADC), called Adcitmer and demonstrated its ...
David Schrama +19 more
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Single-Cell, High-Content Microscopy Analysis of BK Polyomavirus Infection
Microbiology Spectrum, 2023 By adulthood, the majority of the population is persistently infected with BK polyomavirus (BKPyV). Only a subset of the population, generally transplant recipients on immunosuppressive drugs, will experience disease from BKPyV, but those who do have few
Megan C. Procario +3 more
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Taking the Scenic Route: Polyomaviruses Utilize Multiple Pathways to Reach the Same Destination
Viruses, 2020 Members of the Polyomaviridae family differ in their host range, pathogenesis, and disease severity. To date, some of the most studied polyomaviruses include human JC, BK, and Merkel cell polyomavirus and non-human subspecies murine and simian virus 40 ...
Colleen L. Mayberry, Melissa S. Maginnis
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The Ancient Evolutionary History of Polyomaviruses.
PLoS Pathogens, 2016 Polyomaviruses are a family of DNA tumor viruses that are known to infect mammals and birds. To investigate the deeper evolutionary history of the family, we used a combination of viral metagenomics, bioinformatics, and structural modeling approaches to ...
Christopher B Buck +19 more
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