Results 21 to 30 of about 32,631 (184)

Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis

Nature Cell Biology, 2020
Merkel cell carcinoma (MCC)—a neuroendocrine cancer of the skin—is caused by the integration of Merkel cell polyomavirus and persistent expression of large T antigen and small T antigen.
D. Park, Jingwei Cheng, J. Mcgrath, Matthew Y. Lim, Camille H. Cushman, S. Swanson, Michelle L. Tillgren, João A. Paulo, P. Gokhale, L. Florens, M. Washburn, P. Trojer, J. DeCaprio   +12 more
semanticscholar   +1 more source

Histogenesis of Merkel Cell Carcinoma: A Comprehensive Review

Frontiers in Oncology, 2019
Merkel cell carcinoma (MCC) is a primary neuroendocrine carcinoma of the skin. This neoplasia features aggressive behavior, resulting in a 5-year overall survival rate of 40%. In 2008, Feng et al.
Thibault Kervarrec, Thibault Kervarrec, Thibault Kervarrec, Mahtab Samimi, Mahtab Samimi, Serge Guyétant, Serge Guyétant, Bhavishya Sarma, Jérémy Chéret, Emmanuelle Blanchard, Emmanuelle Blanchard, Patricia Berthon, David Schrama, Roland Houben, Antoine Touzé   +14 more
doaj   +1 more source

Fifty Years of JC Polyomavirus: A Brief Overview and Remaining Questions

Viruses, 2020
In the fifty years since the discovery of JC polyomavirus (JCPyV), the body of research representing our collective knowledge on this virus has grown substantially.
Abigail L Atkinson, W. Atwood
semanticscholar   +1 more source

Characterization of ALTO-encoding circular RNAs expressed by Merkel cell polyomavirus and trichodysplasia spinulosa polyomavirus

PLoS Pathogens, 2021
Circular RNAs (circRNAs) are a conserved class of RNAs with diverse functions, including serving as messenger RNAs that are translated into peptides. Here we describe circular RNAs generated by human polyomaviruses (HPyVs), some of which encode variants ...
Rong Yang, Eunice E. Lee, Jiwoong Kim, Joon-Ho Choi, E. Kolitz, Yating Chen, C. Crewe, N. Salisbury, P. Scherer, C. Cockerell, Taylor R Smith, L. Rosen, Louisa Verlinden, D. Galloway, C. Buck, M. Feltkamp, Christopher S. Sullivan, Richard C. Wang   +17 more
semanticscholar   +1 more source

Merkel Cell Polyomavirus and Merkel Cell Carcinoma

Cancers, 2020
Viruses are the cause of approximately 15% of all human cancers. Both RNA and DNA human tumor viruses have been identified, with Merkel cell polyomavirus being the most recent one to be linked to cancer.
V. Pietropaolo, Carla Prezioso, U. Moens
semanticscholar   +1 more source

Structural Basis and Evolution of Glycan Receptor Specificities within the Polyomavirus Family

mBio, 2020
Asymptomatic infections with polyomaviruses in humans are common, but these small viruses can cause severe diseases in immunocompromised hosts. New Jersey polyomavirus (NJPyV) was identified via a muscle biopsy in an organ transplant recipient with ...
Luisa J. Ströh, Nils H. Rustmeier, Bärbel S. Blaum, Josephine Botsch, Philip Rößler, Florian Wedekink, W. Ian Lipkin, Nischay Mishra, Thilo Stehle   +8 more
doaj   +1 more source

Sustained Trichodysplasia Spinulosa Polyomavirus Viremia Illustrating a Primary Disseminated Infection in a Kidney Transplant Recipient

Microorganisms, 2021
Novel human polyomaviruses (HPyV) have been recently identified in solid organ transplant recipients. Trichodysplasia spinulosa (TS) is a rare disease associated with immunosuppression and induced by a polyomavirus (TSPyV).
Marie-Céline Zanella, Damien Pastor, Mariet C. W. Feltkamp, Karine Hadaya, Samuel Cordey, Laurence Toutous Trellu   +5 more
doaj   +1 more source

Whole Genome Sequencing of KI Polyomavirus Strain from Patient with Breast Cancer in Basrah City [PDF]

Journal of Bioscience and Applied Research
Background: Polyomaviruses are small, circular, non-enveloped viruses with a diameter of about 40–50 nm, and have a double-stranded DNA molecule descended from the Polyomaviridae. 32 PyV strains are described, more than 10 of which are reported to infect
akeel Alabadi, Hayder Al-Hmudi, Hassan Habib   +2 more
doaj   +1 more source

Phosphoinositide 3′-Kinase γ Facilitates Polyomavirus Infection

Viruses, 2020
Polyomaviruses are small, non-enveloped DNA tumor viruses that cause serious disease in immunosuppressed people, including progressive multifocal leukoencephalopathy (PML) in patients infected with JC polyomavirus, but the molecular events mediating ...
Paul Clark, Gretchen V. Gee, Brandon S. Albright, Benedetta Assetta, Ying Han, Walter J. Atwood, Daniel DiMaio   +6 more
doaj   +1 more source

Molecular Mechanisms of Merkel Cell Polyomavirus Transformation and Replication

Annual Review of Virology, 2020
Viral infection underlies a significant share of the global cancer burden. Merkel cell polyomavirus (MCPyV) is the newest member of the human oncogenic virus family.
Wei Liu, Jianxin You
semanticscholar   +1 more source